| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2011PNAS..108.4135S |
| P356 | DOI | 10.1073/PNAS.1019581108 |
| P932 | PMC publication ID | 3053975 |
| P698 | PubMed publication ID | 21368114 |
| P5875 | ResearchGate publication ID | 50267102 |
| P50 | author | Adeel Safdar | Q30505500 |
| Jonathan P. Little | Q51093621 | ||
| Mark A Tarnopolsky | Q89229965 | ||
| P2093 | author name string | Bart P Hettinga | |
| Daniel I Ogborn | |||
| Jacqueline M Bourgeois | |||
| Tomas A Prolla | |||
| James E Thompson | |||
| Gregory C Kujoth | |||
| Simon Melov | |||
| Mahmood Akhtar | |||
| Nicholas J Mocellin | |||
| P2860 | cites work | Premature ageing in mice expressing defective mitochondrial DNA polymerase | Q24294365 |
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| Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk | Q36025294 | ||
| Mitochondrial DNA mutations, apoptosis, and the misfolded protein response. | Q36324854 | ||
| A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults | Q36641238 | ||
| Depletion of mitochondrial DNA in fibroblast cultures from patients with POLG1 mutations is a consequence of catalytic mutations | Q36794013 | ||
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| The role of exercise and PGC1alpha in inflammation and chronic disease | Q36984669 | ||
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| PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. | Q37292951 | ||
| Impaired PGC-1alpha function in muscle in Huntington's disease. | Q37323316 | ||
| Exercise: it's the real thing! | Q37400249 | ||
| Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction | Q37414694 | ||
| The biology of PGC-1α and its therapeutic potential | Q37484604 | ||
| The changing shape of mitochondrial apoptosis | Q37568897 | ||
| Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle | Q37591127 | ||
| Physical activity, obesity and risk for esophageal adenocarcinoma. | Q37605867 | ||
| The role of mitochondria in health and disease | Q37606811 | ||
| Physical activity and prevention of cardiovascular disease in older adults | Q37640304 | ||
| Physical inactivity and obesity: relation to asthma and chronic obstructive pulmonary disease? | Q37653468 | ||
| Exercise performance by hemodialysis patients: a review of the literature | Q37667620 | ||
| Somatic mitochondrial DNA mutations in mammalian aging | Q37720726 | ||
| Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise | Q39326231 | ||
| Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old. | Q39667690 | ||
| Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease | Q39905835 | ||
| What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. | Q47182433 | ||
| Accumulation of point mutations in mitochondrial DNA of aging mice | Q47953143 | ||
| Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age | Q48403808 | ||
| Somatic mitochondrial DNA mutations in single neurons and glia. | Q48719653 | ||
| Age-related brain atrophy and mental deterioration—a study with computed tomography | Q52101684 | ||
| Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. | Q53379421 | ||
| A Morphometric Study of the Density of Mitochondrial Cristae in Heart and Liver of Aging Mice | Q67435853 | ||
| Mitochondrial Diseases and Myopathies: A Series of Muscle Biopsy Specimens with Ultrastructural Changes in the Mitochondria | Q67488431 | ||
| High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys | Q70919163 | ||
| Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function | Q74180066 | ||
| Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice | Q79518243 | ||
| Physical activity, function, and longevity among the very old | Q84558868 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 4135-4140 | |
| P577 | publication date | 2011-02-22 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P793 | significant event | expression of concern | Q56478588 |
| P1476 | title | Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice | |
| P478 | volume | 108 |
| Q48014914 | A new model of short acceleration-based training improves exercise performance in old mice. |
| Q56866762 | AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome |
| Q33646728 | Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance |
| Q53811463 | Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease. |
| Q55025189 | Aging Hallmarks: The Benefits of Physical Exercise. |
| Q26830373 | Alpers-Huttenlocher syndrome |
| Q38920425 | Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis |
| Q64076408 | An integrative module analysis of DNA methylation landscape in aging |
| Q28390908 | An intricate dance: Life experience, multisystem resiliency, and rate of telomere decline throughout the lifespan |
| Q37939582 | Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review |
| Q35852789 | Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity |
| Q26865873 | Axis of ageing: telomeres, p53 and mitochondria |
| Q36929398 | Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice |
| Q38949760 | Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle |
| Q35166090 | Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective |
| Q58707243 | Calorie restriction does not influence oocyte quality in oocytes from POLG mitochondrial mutator mice |
| Q35167280 | Can endurance exercise preconditioning prevention disuse muscle atrophy? |
| Q46288550 | Cardiac Aging - Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling |
| Q35898648 | Cardiac aging: from molecular mechanisms to significance in human health and disease |
| Q38216627 | Chasing Mendel: five questions for personalized medicine |
| Q36932851 | Clinical and molecular features of POLG-related mitochondrial disease. |
| Q51563209 | Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle. |
| Q35129909 | Consensus paper: management of degenerative cerebellar disorders |
| Q37934748 | Crosstalk between mitochondrial (dys)function and mitochondrial abundance |
| Q35027977 | Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter |
| Q37210464 | Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society |
| Q92542909 | Distinct Roles of Zmynd17 and PGC1α in Mitochondrial Quality Control and Biogenesis in Skeletal Muscle |
| Q34919832 | Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging |
| Q41115254 | Early goal directed mobility in the ICU: 'something in the way you move'. |
| Q34225916 | Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation |
| Q36479248 | Effects of aerobic training on exercise-related oxidative stress in mitochondrial myopathies. |
| Q41392862 | Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men. |
| Q36269887 | Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice |
| Q90624317 | Effects of clenbuterol administration on mitochondrial morphology and its regulatory proteins in rat skeletal muscle |
| Q64354624 | Emerging therapies for mitochondrial diseases |
| Q26773005 | Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases |
| Q36930817 | Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. |
| Q38227791 | Exercise as a therapeutic strategy for primary mitochondrial cytopathies |
| Q34449998 | Exercise attenuates the major hallmarks of aging |
| Q50973442 | Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice. |
| Q26744618 | Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging |
| Q35935174 | Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. |
| Q51823337 | Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise. |
| Q26825012 | Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration |
| Q26738573 | Frailty in mouse ageing: A conceptual approach |
| Q29871472 | GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. |
| Q38153331 | Gait ataxia--specific cerebellar influences and their rehabilitation |
| Q37162595 | Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease. |
| Q35865700 | High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice |
| Q47608498 | Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition |
| Q64888134 | Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse. |
| Q84987787 | Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice |
| Q37715483 | Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1. |
| Q43145332 | In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. |
| Q35909435 | Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse |
| Q33637336 | Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease |
| Q38649815 | Inherited mitochondrial genomic instability and chemical exposures |
| Q51760977 | Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging? |
| Q36635352 | Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging |
| Q33848709 | Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study |
| Q28544021 | MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants |
| Q34311406 | Maternally transmitted mitochondrial DNA mutations can reduce lifespan |
| Q38196701 | Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. |
| Q36173652 | Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain |
| Q33813591 | Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue |
| Q27011752 | Mitochondria and cardiovascular aging |
| Q28391449 | Mitochondria and oxidative stress in heart aging |
| Q37990817 | Mitochondria in vascular disease |
| Q38453882 | Mitochondria, muscle health, and exercise with advancing age. |
| Q51164584 | Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri. |
| Q35065267 | Mitochondrial DNA copy number in peripheral blood leukocytes and the risk of clear cell renal cell carcinoma. |
| Q35660977 | Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function |
| Q35893619 | Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies |
| Q61809068 | Mitochondrial Heterogeneity |
| Q47728491 | Mitochondrial Toxicity |
| Q26823283 | Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats |
| Q38198954 | Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids. |
| Q97569060 | Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss |
| Q36086384 | Mitochondrial dysfunction in aging: Much progress but many unresolved questions |
| Q38205924 | Mitochondrial free radical theory of aging: who moved my premise? |
| Q38228592 | Mitochondrial function and mitochondrial DNA maintenance with advancing age. |
| Q33821051 | Mitochondrial genome maintenance in health and disease. |
| Q27025099 | Mitochondrial oxidative stress in aging and healthspan |
| Q57289845 | Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15Ra |
| Q37353896 | Molecular mechanisms of treadmill therapy on neuromuscular atrophy induced via botulinum toxin A. |
| Q42069761 | Natural selection of mitochondria during somatic lifetime promotes healthy aging |
| Q35056811 | Nitric oxide, interorganelle communication, and energy flow: a novel route to slow aging |
| Q37381822 | Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription |
| Q47988632 | Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems. |
| Q38286167 | Optimizing the measurement of mitochondrial protein synthesis in human skeletal muscle |
| Q27330184 | PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle |
| Q38884029 | Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation. |
| Q35234072 | Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences. |
| Q64900318 | Perspective: Why Exercise Is Good and Its Lack Bad for Everything. |
| Q36553629 | Pharmacological lifespan extension of invertebrates |
| Q92556826 | Physical Exercise and Mitochondrial Disease: Insights From a Mouse Model |
| Q36665888 | Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults |
| Q88032603 | Physiological Redundancy and the Integrative Responses to Exercise |
| Q58751674 | Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing |
| Q35145466 | Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain |
| Q28078384 | Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment |
| Q27023983 | Promotion of lung health: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases |
| Q47550262 | Psychological Stress and Mitochondria: A Conceptual Framework. |
| Q28084341 | Quality control systems in cardiac aging |
| Q36522375 | RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice |
| Q50115780 | Recent insights into the cellular and molecular determinants of aging. |
| Q38824997 | Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases |
| Q26824141 | Running forward: new frontiers in endurance exercise biology |
| Q51143243 | Sarcolipin expression is not required for the mitochondrial enzymatic response to physical activity or diet. |
| Q35195513 | Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study |
| Q36902292 | Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice. |
| Q36809107 | Skeletal muscle aging and the mitochondrion |
| Q37925835 | Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis |
| Q37936446 | Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection |
| Q36927484 | Skeletal muscle contractile function and neuromuscular performance in Zmpste24 -/- mice, a murine model of human progeria |
| Q38165741 | Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease. |
| Q34944863 | Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice |
| Q37033248 | Telomeres and mitochondria in the aging heart |
| Q45833603 | The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10. |
| Q33705451 | The Crosstalk between the Gut Microbiota and Mitochondria during Exercise |
| Q36654160 | The Mitochondrial Basis of Aging |
| Q28397317 | The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms |
| Q37211891 | The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. |
| Q27008819 | The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair |
| Q37026064 | The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. |
| Q36762813 | The elusive magic pill: finding effective therapies for mitochondrial disorders |
| Q36878648 | The exonuclease activity of the yeast mitochondrial DNA polymerase γ suppresses mitochondrial DNA deletions between short direct repeats in Saccharomyces cerevisiae |
| Q28131641 | The hallmarks of aging |
| Q37337242 | The influence of skeletal muscle on systemic aging and lifespan |
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| Q38190176 | The many roles of PGC-1α in muscle--recent developments |
| Q38845636 | The potential of endurance exercise-derived exosomes to treat metabolic diseases. |
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