| Q36347163 | A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation |
| Q24291177 | A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA |
| Q33579422 | A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. |
| Q39489229 | Accelerated aging syndromes, are they relevant to normal human aging? |
| Q28252282 | Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity |
| Q33567691 | Acetylation of WRN protein regulates its stability by inhibiting ubiquitination |
| Q35621362 | Ageing, repetitive genomes and DNA damage |
| Q82300194 | Altered nuclear functions in progeroid syndromes: a paradigm for aging research |
| Q36320325 | Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair |
| Q37764043 | Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin |
| Q36169847 | Bridging the gap: ageing, pharmacokinetics and pharmacodynamics. |
| Q35548600 | Caspases, apoptosis and aging |
| Q34608450 | Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene |
| Q35815320 | Cellular senescence and organismal aging |
| Q24515331 | Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase |
| Q36978266 | Clinical relevance of the homologous recombination machinery in cancer therapy |
| Q48329622 | Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta |
| Q48382475 | Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4. |
| Q34498808 | Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells |
| Q28512334 | Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1 |
| Q93103734 | DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy |
| Q37194578 | DNA damage, vascular senescence and atherosclerosis. |
| Q33938090 | Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4. |
| Q28144342 | Deletion of Ku86 causes early onset of senescence in mice |
| Q34207950 | Disease model: human aging |
| Q33684409 | Distinct roles of RECQ1 in the maintenance of genomic stability |
| Q24291356 | Diverged nuclear localization of Werner helicase in human and mouse cells |
| Q42130385 | Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase |
| Q34736706 | Does p53 affect organismal aging? |
| Q36380597 | Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging |
| Q33904684 | Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth |
| Q34645436 | Dysregulation of RNA polymerase I transcription during disease. |
| Q91763092 | Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1) |
| Q28242111 | Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer |
| Q28588253 | Essential role of limiting telomeres in the pathogenesis of Werner syndrome |
| Q90096763 | Evidence for premature aging in a Drosophila model of Werner syndrome |
| Q37357635 | Expression differences by continent of origin point to the immortalization process |
| Q34460106 | Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span. |
| Q33533472 | Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide |
| Q36895328 | From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. |
| Q37385175 | Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation |
| Q24684308 | Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice |
| Q44145923 | Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis |
| Q35150807 | Genetically altered mouse models: the good, the bad, and the ugly |
| Q26740026 | Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells |
| Q37939634 | Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance |
| Q36101160 | Human RecQ helicases in DNA repair, recombination, and replication. |
| Q37046783 | Improvement of aortic valve stenosis by ApoA-I mimetic therapy is associated with decreased aortic root and valve remodelling in mice |
| Q44606711 | Instability of the fragile X syndrome repeat in mice: the effect of age, diet and mutations in genes that affect DNA replication, recombination and repair proficiency |
| Q33338420 | Interaction between proliferating cell nuclear antigen and JUN-activation-domain-binding protein 1 in the meristem of rice, Oryza sativa L. |
| Q35217314 | Invited review: Theories of aging. |
| Q22253994 | Ku complex interacts with and stimulates the Werner protein |
| Q34667124 | Large genome rearrangements as a primary cause of aging |
| Q34152612 | Liver aging and pseudocapillarization in a Werner syndrome mouse model. |
| Q34533223 | Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways |
| Q42214018 | Loss of p16(Ink4a) function rescues cellular senescence induced by telomere dysfunction |
| Q51767082 | Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency. |
| Q43586163 | Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus. |
| Q90372589 | MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner |
| Q43097729 | MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency |
| Q26740310 | Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer |
| Q30882791 | Mechanisms of resistance to topoisomerase I-targeting drugs |
| Q27313716 | Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice |
| Q34922762 | Metabolism, genomics, and DNA repair in the mouse aging liver |
| Q24644033 | Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes |
| Q26826949 | Modeling the study of DNA damage responses in mice |
| Q33755724 | Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage |
| Q34106251 | Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination‐Mediated DNA Deletion |
| Q34447472 | Mouse models of inherited cancer syndromes |
| Q39647670 | Mouse telomere analysis using an optimized primed in situ (PRINS) labeling technique |
| Q28510148 | Mutations in the WRN gene in mice accelerate mortality in a p53-null background |
| Q36664165 | Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. |
| Q48736506 | On key lesions and all that: a tribute to Paul Lohman |
| Q33875710 | Physical and functional interaction between p53 and the Werner's syndrome protein |
| Q35676137 | RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. |
| Q26829765 | RECQL4 in genomic instability and aging |
| Q64386405 | RECQL5 plays co-operative and complementary roles with WRN syndrome helicase |
| Q35026401 | RecQ family helicases: roles as tumor suppressor proteins |
| Q33840427 | RecQ family helicases: roles in cancer and aging |
| Q34994566 | RecQ helicases and cellular responses to DNA damage |
| Q29618390 | RecQ helicases: caretakers of the genome |
| Q37573385 | RecQ helicases: multifunctional genome caretakers |
| Q35152970 | RecQ helicases: suppressors of tumorigenesis and premature aging. |
| Q28244037 | Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease |
| Q28214575 | Recombinational DNA repair and human disease |
| Q37035110 | Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment |
| Q27329025 | Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation |
| Q24306868 | Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation |
| Q49383418 | Relevance of the p53-MDM2 axis to aging |
| Q36557533 | Repair of topoisomerase I-mediated DNA damage |
| Q42591444 | Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. |
| Q42848227 | Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome |
| Q28271011 | Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells |
| Q35132675 | Roles of RecQ family helicases in the maintenance of genome stability |
| Q34519481 | Roles of the Werner syndrome protein in pathways required for maintenance of genome stability |
| Q33616272 | Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. |
| Q36978188 | Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents |
| Q37590850 | Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks |
| Q49921106 | Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein |
| Q33844435 | Somatic mutations and aging: a re-evaluation |
| Q33843105 | Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 |
| Q35879313 | Structural organization and functions of the nucleus in development, aging, and disease |
| Q29615353 | Telomeres and human disease: ageing, cancer and beyond |
| Q40115121 | The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro |
| Q24561510 | The RecQ DNA Helicases in DNA Repair |
| Q37595175 | The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation. |
| Q35577695 | The Werner Syndrome Helicase-Nuclease--One Protein, Many Mysteries |
| Q33899444 | The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases |
| Q34966683 | The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice |
| Q36903638 | The Werner syndrome protein is involved in RNA polymerase II transcription |
| Q28155868 | The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein |
| Q27621065 | The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins |
| Q29614976 | Topoisomerase I inhibitors: camptothecins and beyond |
| Q35592814 | Toward cell replacement therapy: promises and caveats |
| Q24306196 | Tpp1/Acd maintains genomic stability through a complex role in telomere protection |
| Q38669051 | Unique features of trabectedin mechanism of action. |
| Q34818981 | Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes |
| Q51766385 | Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein. |
| Q35001920 | Vitamin C restores healthy aging in a mouse model for Werner syndrome |
| Q37586984 | WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects |
| Q34125040 | WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex |
| Q33613095 | WRN helicase expression in Werner syndrome cell lines |
| Q42004182 | WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase |
| Q37021622 | WRN protects against topo I but not topo II inhibitors by preventing DNA break formation |
| Q39775619 | WRN protein and Werner syndrome |
| Q21146988 | Werner Syndrome |
| Q36798321 | Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. |
| Q28206293 | Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation |
| Q24674594 | Werner protein recruits DNA polymerase delta to the nucleolus |
| Q33786685 | Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. |
| Q64054862 | Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells |
| Q39895677 | Werner syndrome protein limits MYC-induced cellular senescence |
| Q40840880 | Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage |
| Q28373681 | Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle |
| Q30983796 | Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest |
| Q33944087 | Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle |
| Q33731898 | What geriatricians should know about the Werner syndrome |
| Q64272430 | p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis |
| Q24603148 | p53-mediated apoptosis is attenuated in Werner syndrome cells |
| Q36028209 | p53: traffic cop at the crossroads of DNA repair and recombination |