Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways

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Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...752167C
P356DOI10.1371/JOURNAL.PONE.0052167
P932PMC publication ID3524112
P698PubMed publication ID23284920
P5875ResearchGate publication ID234043757

P2093author name stringDavid J Picketts
Robin J Parks
Emma Goodall
Damiano Conte
Marilyne Delorme
Michael Huh
P2860cites workAlpha thalassaemia-mental retardation, X linkedQ21203051
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomesQ22010822
Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin associationQ22253267
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylationQ22253401
Nuclear structure in normal and Bloom syndrome cellsQ22253976
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeresQ24292850
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardationQ24296972
Critical role for Daxx in regulating Mdm2Q24297332
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9Q24297608
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)Q24311995
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3Q24315621
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesQ24317166
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodiesQ24319767
Interaction of human recombination proteins Rad51 and Rad54Q24545517
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesisQ24557516
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatinQ27670415
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeQ27670417
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsQ28114801
5-Fluorouracil: mechanisms of action and clinical strategiesQ28201937
Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 proteinQ28264443
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
Mutations in the chromatin-associated protein ATRX.Q51891945
Patient mutations alter ATRX targeting to PML nuclear bodies.Q51898063
Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis.Q53222824
Clinical development of platinum complexes in cancer therapy: an historical perspective and an update.Q53559996
MyoD is required for myogenic stem cell function in adult skeletal muscleQ71172968
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumorsQ28303693
Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndromeQ28304264
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome geneQ28505487
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndromeQ28508472
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacityQ28589633
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functionsQ29618531
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissuesQ33240549
Loss of ATRX in chondrocytes has minimal effects on skeletal developmentQ33506092
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathwayQ34350929
Toll receptors, CD14, and macrophage activation and deactivation by LPS.Q34727357
Strand pairing by Rad54 and Rad51 is enhanced by chromatinQ35804759
Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expressionQ35843809
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signalQ35915922
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomasQ36236484
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctionsQ36972650
Acquired somatic ATRX mutations in myelodysplastic syndrome associated with α thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutationsQ38450295
Construction and characterization of adenovirus vectorsQ39741237
Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectorsQ40582642
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome proteinQ40584630
Cancer therapy utilizing an adenoviral vector expressing only E1A.Q40737438
Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formationQ40959743
Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectorsQ41102151
Loss of ATRX leads to chromosome cohesion and congression defectsQ41825660
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.Q41938609
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survivalQ43181903
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutationsQ44269667
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatinQ44270140
Expression of macrophage CD44 receptor in the course of experimental inflammatory response of bovine mammary gland induced by lipopolysaccharide and muramyl dipeptideQ46386732
dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activationQ47072310
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.Q47407852
dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neuronsQ47908812
Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domainsQ48038450
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)e52167
P577publication date2012-12-17
P1433published inPLOS OneQ564954
P1476titleLoss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways
P478volume7

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cites work (P2860)
Q39071428ATRX and DAXX: Mechanisms and Mutations
Q90346173Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
Q52657331Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.
Q26740256DNA repair mechanisms and their clinical impact in glioblastoma
Q92367904Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer
Q91905154Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity
Q34490850Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres
Q49719068Inferences of individual drug responses across diverse cancer types using a novel competing endogenous RNA network
Q36873846Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma
Q55456861Mutant ATRX: uncovering a new therapeutic target for glioma.
Q45999303Prospective feasibility trial for genomics-informed treatment in recurrent and progressive glioblastoma.
Q89634172The Personalisation of Glioblastoma Treatment Using Whole Exome Sequencing: A Pilot Study
Q42369808The Role of ATRX in Glioma Biology
Q38454659Toward precision medicine in glioblastoma: the promise and the challenges
Q36008475Unbiased phosphoproteomic method identifies the initial effects of a methacrylic acid copolymer on macrophages

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