Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

scientific article

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKV847
P932PMC publication ID4666390
P698PubMed publication ID26304540
P5875ResearchGate publication ID281311393

P50authorLee H WongQ56438118
Jeffrey R MannQ63698596
P2093author name stringPhilippe Collas
Hilda A Pickett
F Lyn Chan
Maheshi Udugama
Lynne Mayne
James D R McGhie
Fiona T M Chang
Michelle C Tang
P2860cites workDaxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeresQ24292850
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesisQ24304348
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3Q24315621
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatinQ24317426
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomasQ24629777
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatinQ27670415
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeQ27670417
Chromatin modifications and their functionQ27861067
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsQ28114801
Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse.Q50765147
Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.Q51543312
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.Q51598430
Stable G-quadruplexes are found outside nucleosome-bound regions.Q54687435
Genome-wide analysis predicts DNA structural motifs as nucleosome exclusion signalsQ66777985
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activityQ84946960
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsQ28116571
Regulation of replication fork progression through histone supply and demandQ28261912
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
The G4 genomeQ28289973
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumorsQ28303693
PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cellsQ28587544
Contribution of the two genes encoding histone variant h3.3 to viability and fertility in miceQ28591185
Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencingQ28591651
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assemblyQ29618256
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stabilityQ29620365
Histone H3.3 is enriched in covalent modifications associated with active chromatinQ33196967
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissuesQ33240549
Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1Q33606891
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
Molecular pathology and genetics of pancreatic endocrine tumours.Q34274982
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathwayQ34350929
ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.Q34471329
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cellsQ34474887
Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of TelomeresQ34490971
Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathwaysQ34533223
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic stateQ34575324
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.Q34729916
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypesQ35235698
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regionsQ35534127
Active transcription and essential role of RNA polymerase II at the centromere during mitosisQ35751023
Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variantQ36438477
Association of age at diagnosis and genetic mutations in patients with neuroblastoma.Q36480024
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumorsQ36541359
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.Q36793436
DNA secondary structures: stability and function of G-quadruplex structuresQ37051064
Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cellsQ37142011
H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin.Q37362553
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.Q37624289
Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cellsQ37961786
The chromatin remodeller ATRX: a repeat offender in human diseaseQ38126641
Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA.Q39090477
Telomeric repeats act as nucleosome-disfavouring sequences in vivoQ41941289
Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.Q41945558
Transcriptional activation triggers deposition and removal of the histone variant H3.3.Q42122747
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.Q42209064
Atrx promotes heterochromatin formation at retrotransposonsQ42389920
DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCsQ42826399
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex.Q43175284
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.Q45262911
Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcriptionQ46861232
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.Q47068818
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.Q47407852
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)10227-10237
P577publication date2015-08-24
P1433published inNucleic Acids ResearchQ135122
P1476titleHistone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres
P478volume43

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cites work (P2860)
Q58727164ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner
Q47766696Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape.
Q92443471Alternative Lengthening of Telomeres and Chromatin Status
Q51645621Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors.
Q47108479Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity
Q47137522CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx
Q64889834Centromeric and ectopic assembly of CENP-A chromatin in health and cancer: old marks and new tracks.
Q50193501Epigenetic regulation in cell senescence
Q47352829Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila
Q30043364H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potential memory mark for virulence gene expression in Plasmodium falciparum
Q38882222H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.
Q38733118HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress
Q64104141Histone Modifications and the Maintenance of Telomere Integrity
Q37143027Histone turnover and chromatin accessibility: Critical mediators of neurological development, plasticity, and disease
Q39031041Histone variants on the move: substrates for chromatin dynamics
Q40292496Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome
Q39021931Life and cancer without telomerase: ALT and other strategies for making sure ends (don't) meet.
Q106089349Local Enrichment of HP1alpha at Telomeres Alters Their Structure and Regulation of Telomere Protection
Q58765323Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection
Q26765418Maintaining memory of silencing at imprinted differentially methylated regions
Q26775163Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
Q91949069Molecular effects of dADD1 misexpression in chromatin organization and transcription
Q98735817Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function
Q26771668New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
Q91843058PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Q38877286PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX.
Q33674324Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites
Q27306288RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition
Q52579677Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Q64062855SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres
Q39119025Silencing of endogenous retroviruses by heterochromatin
Q48103225Telomere chromatin establishment and its maintenance during mammalian development.
Q39025713The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals.
Q52532574The tale of a tail: histone H4 acetylation and the repair of DNA breaks.

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