Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis.

scientific article published in September 2011

Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.081612
P698PubMed publication ID21878502
P5875ResearchGate publication ID51606305

P50authorBoris ZhivotovskyQ30158891
P2093author name stringStefan Imreh
Gabriela Imreh
Helin Vakifahmetoglu Norberg
P2860cites workFunctional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damageQ24323139
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stressQ24336121
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in miceQ28143813
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damageQ28145962
The many substrates and functions of ATMQ28205055
ATR disruption leads to chromosomal fragmentation and early embryonic lethalityQ28591433
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinQ33540751
DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpointQ33762022
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosisQ33965393
Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitroQ34551081
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cellsQ34625589
Apoptosis regulation in tetraploid cancer cellsQ34676609
Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instabilityQ34775052
BUB1 mediation of caspase-independent mitotic death determines cell fateQ36118820
Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution.Q36323376
Structure meets function--centrosomes, genome maintenance and the DNA damage responseQ36541054
DNA damage signaling in response to double-strand breaks during mitosisQ39675593
An essential role for p73 in regulating mitotic cell deathQ39763275
Mitotic catastrophe is the predominant response to histone acetyltransferase depletionQ39903511
In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomideQ40017220
Sustained metaphase arrest in response to ionizing radiation in a non-small cell lung cancer cell lineQ40030903
DNA damage induces two distinct modes of cell death in ovarian carcinomasQ40038486
Bcl-xL blocks high dose doxorubicin-induced apoptosis but not low dose doxorubicin-induced cell death through mitotic catastropheQ40070545
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastropheQ40373985
Phosphorylation of histone H2AX at M phase in human cells without DNA damage responseQ40375352
Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosisQ40394920
Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotypeQ40426933
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.Q40572671
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastropheQ40572677
Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosisQ40697544
Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakageQ41492190
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpointQ46058691
DISC-mediated activation of caspase-2 in DNA damage-induced apoptosisQ46060882
Caspase-independent apoptosis is activated by diazepam-induced mitotic failure in HeLa cells, but not in human primary fibroblastsQ46679736
In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assayQ48534904
Chromosomes of X-ray-induced Giant Cells in Chinese Hamster in vitroQ58969564
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21Q59054204
P433issuePt 17
P407language of work or nameEnglishQ1860
P304page(s)2951-2963
P577publication date2011-09-01
P1433published inJournal of Cell ScienceQ1524177
P1476titleChromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis.
P478volume124