Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction

scientific article published on May 16, 2012

Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS13055866
P953full work available at URLhttps://europepmc.org/articles/PMC3382785
https://europepmc.org/articles/PMC3382785?pdf=render
https://www.mdpi.com/1422-0067/13/5/5866/pdf
https://www.mdpi.com/1422-0067/13/5/5866/pdf?version=1403144221
P932PMC publication ID3382785
P698PubMed publication ID22754337
P5875ResearchGate publication ID228106114

P2093author name stringYing Luo
Xiaoming Wu
Xiufeng Zhang
Wenru Tang
P2860cites workTelomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
The Werner syndrome protein is a DNA helicaseQ24310486
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescenceQ24650807
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2Q28116237
Shelterin: the protein complex that shapes and safeguards human telomeresQ28272546
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genesQ28509192
Essential role of limiting telomeres in the pathogenesis of Werner syndromeQ28588253
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacityQ28589633
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
Aging or tumor: the crosstalk between telomerase and p53Q28611406
Protection of mammalian telomeresQ29618391
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesisQ33862956
Mice without telomerase: what can they teach us about human cancer?Q33995041
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging processQ34231189
p16INK4a as a second effector of the telomere damage pathwayQ36264069
Telomeres: cancer to human agingQ36528826
Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblastsQ37764045
Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profileQ38289694
Different telomere damage signaling pathways in human and mouse cellsQ39647901
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescenceQ39674577
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Q40481955
Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene statusQ41098520
A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging ProcessQ55953422
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient MiceQ56508064
Significant Role for p16INK4a in p53-Independent Telomere-Directed SenescenceQ56969662
Telomere positional effects and the regulation of cellular senescenceQ68007322
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblastsQ73311217
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?Q75294424
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcellular senescenceQ9075999
P304page(s)5866-5877
P577publication date2012-05-16
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleLoss of p16(Ink4a) function rescues cellular senescence induced by telomere dysfunction
Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
P478volume13

Reverse relations

cites work (P2860)
Q36502521Effects of rhein lysinate on D-galactose-induced aging mice
Q34757728Long-term quiescent fibroblast cells transit into senescence
Q30442295Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration
Q58698149Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer
Q38873145Telomeres and Cell Senescence - Size Matters Not.
Q34490369Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores

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