Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha

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Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M208605200
P698PubMed publication ID12637557

P2093author name stringShigenori Iwai
Motoshi Suzuki
Shonen Yoshida
Masanori Ogawa
Siripan Limsirichaikul
Atsuko Niimi
P2860cites workMutations in human DNA polymerase eta motif II alter bypass of DNA lesionsQ24536098
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugsQ24644933
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonariusQ27617780
Crystal structure of an archaebacterial DNA polymeraseQ27620205
Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7Q27624999
Structure of the replicating complex of a pol alpha family DNA polymeraseQ27632340
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69Q27740210
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolutionQ27748814
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystalQ27748815
The DNA replication fork in eukaryotic cells.Q27939216
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sitesQ28131597
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.Q29616842
DNA polymerases: structural diversity and common mechanismsQ29619403
Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selectionQ30667746
DNA polymerase active site is highly mutable: evolutionary consequencesQ30869765
Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.Q30929263
Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69.Q31777720
Eukaryotic DNA polymerases: proposal for a revised nomenclature.Q34093113
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotidesQ34117923
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesisQ34118869
Temperature-sensitive mutations in the yeast DNA polymerase I geneQ34618611
The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cellsQ36425987
Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes.Q36555338
De novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phaseQ36659454
Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structureQ36817752
Tolerance of different proteins for amino acid diversityQ36873408
Transposon Tn5 excision in yeast: influence of DNA polymerases alpha, delta, and epsilon and repair genesQ37599112
Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).Q38299557
ø29 DNA polymerase residue Lys383, invariant at motif B of DNA-dependent polymerases, is involved in dNTP binding.Q38345027
The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect onesQ38356754
Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation stepQ39229297
Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase deltaQ39455847
Mutator phenotype induced by aberrant replicationQ39610863
Synthesis and characterization of a substrate for T4 endonuclease V containing a phosphorodithioate linkage at the thymine dimer siteQ40527521
Biochemical basis of DNA replication fidelityQ40903454
Mutational studies of human DNA polymerase alpha. Lysine 950 in the third most conserved region of alpha-like DNA polymerases is involved in binding the deoxynucleoside triphosphateQ42065679
The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutableQ43560044
O-helix mutant T664P of Thermus aquaticus DNA polymerase I: altered catalytic properties for incorporation of incorrect nucleotides but not correct nucleotidesQ43603086
In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.Q43767918
A mutant of DNA polymerase I (Klenow fragment) with reduced fidelityQ44945167
Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coliQ45771082
A table for the estimation of the spontaneous mutations rate of cells in cultureQ52957251
Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I.Q54567474
Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomainQ73119494
Proofreading of DNA polymerase eta-dependent replication errorsQ73288765
Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helixQ74036849
Getting a grip on how DNA polymerases functionQ74266456
How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotidesQ74507055
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)Q77896965
Steady-state kinetic characterization of RB69 DNA polymerase mutants that affect dNTP incorporationQ77937570
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)19071-19078
P577publication date2003-03-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleDistinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha
P478volume278

Reverse relations

cites work (P2860)
Q36636009A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site
Q53836474Activity and fidelity of human DNA polymerase α depend on primer structure.
Q26991961DNA polymerase delta in DNA replication and genome maintenance
Q41495257Hypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase
Q33344620INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana.
Q37483304Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools
Q37482417PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha}.
Q37011650Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity
Q38356754The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones
Q40773283The alpha4 residues of human DNA topoisomerase IIalpha function in enzymatic activity and anticancer drug sensitivity
Q42467404The role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrients

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