| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2000PNAS...97.5095P |
| P356 | DOI | 10.1073/PNAS.97.10.5095 |
| P932 | PMC publication ID | 25787 |
| P698 | PubMed publication ID | 10805772 |
| P5875 | ResearchGate publication ID | 12511589 |
| P2093 | author name string | L A Loeb | |
| P H Patel | |||
| P2860 | cites work | Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP | Q27729369 |
| Structure of DNA polymerase I Klenow fragment bound to duplex DNA | Q27732134 | ||
| Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69 | Q27740210 | ||
| Calibrating bacterial evolution | Q28776463 | ||
| Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. | Q29616842 | ||
| Evolution in bacteria: evidence for a universal substitution rate in cellular genomes | Q29618187 | ||
| Improving enzymes for cancer gene therapy | Q30650758 | ||
| Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases | Q32016682 | ||
| Rapid purification of recombinant Taq DNA polymerase by freezing and high temperature thawing of bacterial expression cultures | Q34779330 | ||
| Marked infidelity of human immunodeficiency virus type 1 reverse transcriptase at RNA and DNA template ends | Q34983363 | ||
| Estimates of the overall rate of growth of the intestinal microflora of hamsters, guinea pigs, and mice. | Q35147577 | ||
| Proliferation of mutators in A cell population | Q35618973 | ||
| Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli | Q36308773 | ||
| High-copy-number and low-copy-number plasmid vectors for lacZ alpha-complementation and chloramphenicol- or kanamycin-resistance selection | Q36448348 | ||
| Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria | Q36801155 | ||
| Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure | Q36817752 | ||
| Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy | Q37660477 | ||
| Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase | Q38296391 | ||
| Mutants generated by the insertion of random oligonucleotides into the active site of the beta-lactamase gene | Q38344109 | ||
| Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli | Q45771082 | ||
| High mutation frequencies among Escherichia coli and Salmonella pathogens | Q48057867 | ||
| Single-step purification of a thermostable DNA polymerase expressed in Escherichia coli | Q48069445 | ||
| Clonal divergence in Escherichia coli as a result of recombination, not mutation | Q48077857 | ||
| Role of mutator alleles in adaptive evolution. | Q54564129 | ||
| Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases. | Q54639795 | ||
| How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides | Q74507055 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 5095-5100 | |
| P577 | publication date | 2000-05-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | DNA polymerase active site is highly mutable: evolutionary consequences | |
| P478 | volume | 97 |
| Q43509472 | A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity |
| Q39229297 | Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation step |
| Q38301444 | Biochemical properties of a plastidial DNA polymerase of rice |
| Q54679413 | Characterisation of a DNA polymerase highly mutated along the template binding interface. |
| Q36162296 | Chips and SNPs, bugs and thugs: a molecular sleuthing perspective |
| Q34106687 | Clinical and molecular findings in osteoporosis-pseudoglioma syndrome |
| Q40777650 | DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination |
| Q28506592 | DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes |
| Q28652878 | DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides |
| Q31056280 | Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase |
| Q30897941 | Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha |
| Q33997867 | Engineering processive DNA polymerases with maximum benefit at minimum cost |
| Q30670944 | Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis |
| Q88775163 | Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries |
| Q24316458 | Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links |
| Q45010727 | Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. |
| Q42215235 | Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering |
| Q33700686 | Frail hypotheses in evolutionary biology |
| Q33273825 | Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. |
| Q27666061 | Human DNA Polymerase Mutations Allowing Efficient Abasic Site Bypass |
| Q61444311 | Identification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library |
| Q43767918 | In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection. |
| Q24562014 | JavaProtein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structure |
| Q33312943 | Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase |
| Q33222949 | Laboratory-directed protein evolution |
| Q27667194 | Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity |
| Q28543483 | Mechanism of suppression of chromosomal instability by DNA polymerase POLQ |
| Q30929263 | Multiple amino acid substitutions allow DNA polymerases to synthesize RNA. |
| Q34327554 | Multiple mutations and cancer |
| Q30714159 | Novel concepts for selection of catalytic activity |
| Q42815933 | Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114. |
| Q33667067 | Optimization of DNA polymerase mutation rates during bacterial evolution |
| Q24304200 | POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 |
| Q39502754 | Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains |
| Q28266927 | Protein tolerance to random amino acid change |
| Q33199293 | Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase |
| Q34975909 | Shotgun metagenomics indicates novel family A DNA polymerases predominate within marine virioplankton. |
| Q21146061 | Structure-guided recombination creates an artificial family of cytochromes P450. |
| Q35225471 | Template properties of mutagenic cytosine analogues in reverse transcription |
| Q38356754 | The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones |
| Q40423246 | The Translesion Polymerase ζ Has Roles Dependent on and Independent of the Nuclease MUS81 and the Helicase RECQ4A in DNA Damage Repair in Arabidopsis. |
| Q35052557 | The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum |
| Q43560044 | The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable |
| Q35137906 | The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity |
| Q44569160 | The essential C family DnaE polymerase is error-prone and efficient at lesion bypass |
| Q39665739 | The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases |
| Q30423335 | The role of electrostatic interactions on klentaq1 insight for domain separation |
| Q34464882 | Three R's of bacterial evolution: how replication, repair, and recombination frame the origin of species |
| Q40989492 | Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs |
| Q33952911 | Visualizing high error levels during gene expression in living bacterial cells. |
Search more.