Optimization of DNA polymerase mutation rates during bacterial evolution

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Optimization of DNA polymerase mutation rates during bacterial evolution is …
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scholarly articleQ13442814

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P819ADS bibcode2010PNAS..107.1154L
P356DOI10.1073/PNAS.0912451107
P932PMC publication ID2824296
P698PubMed publication ID20080608
P5875ResearchGate publication ID41040275

P2093author name stringLawrence A Loeb
Ern Loh
Jesse J Salk
P2860cites workEvolution of the Genetic Apparatus: A ReviewQ22065734
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Defective DNA polymerase-delta proofreading causes cancer susceptibility in miceQ73954766
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RNA virus error catastrophe: direct molecular test by using ribavirinQ24599371
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Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteriaQ28769089
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.Q30400206
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.Q30408086
DNA polymerase active site is highly mutable: evolutionary consequencesQ30869765
Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.Q33273825
The distribution of rates of spontaneous mutation over viruses, prokaryotes, and eukaryotesQ33692274
Evolution of evolvability.Q33692297
Direct selection for mutators in Escherichia coli.Q33991388
Error catastrophe and antiviral strategyQ34153584
Evolving responsively: adaptive mutationQ34297067
DNA polymerases and somatic hypermutation of immunoglobulin genesQ34360690
Evolution of high mutation rates in experimental populations of E. coliQ34429727
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteriaQ34607018
The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitnessQ34609052
Saturation of DNA mismatch repair and error catastrophe by a base analogue in Escherichia coli.Q34615754
Proliferation of mutators in A cell populationQ35618973
Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I.Q35813374
Mutational heterogeneity in human cancers: origin and consequences.Q36031579
Overproduction of DnaE protein (alpha subunit of DNA polymerase III) restores viability in a conditionally inviable Escherichia coli strain deficient in DNA polymerase IQ36112741
The promise and peril of continuous in vitro evolutionQ36184475
Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastropheQ37678547
Evolutionarily stable mutation rate in a periodically changing environment.Q42960953
Evolutionary biology: Arrhythmia of tempo and modeQ43253094
The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutableQ43560044
In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.Q43767918
Fitness of an Escherichia coli Mutator GeneQ45158915
Use of Pol I-deficient E. coli for functional complementation of DNA polymerase.Q53859920
Role of mutator alleles in adaptive evolution.Q54564129
Analyzing fidelity of DNA polymerases.Q54619712
Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coliQ54684426
The cost of replication fidelity in human immunodeficiency virus type 1.Q55430533
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectbacterial evolutionQ115395667
P1104number of pages6
P304page(s)1154-1159
P577publication date2009-12-28
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOptimization of DNA polymerase mutation rates during bacterial evolution
P478volume107

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