scholarly article | Q13442814 |
P2093 | author name string | Michael D Wyatt | |
Zhengguan Yang | |||
Alan S Waldman | |||
P2860 | cites work | ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage | Q24306743 |
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair | Q24338781 | ||
5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity | Q27863350 | ||
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress | Q28201846 | ||
The consequences of Rad51 overexpression for normal and tumor cells | Q28266986 | ||
Replication protein A phosphorylation and the cellular response to DNA damage | Q28274289 | ||
Cell-cycle checkpoints and cancer | Q28293996 | ||
Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks | Q28294399 | ||
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death | Q29614845 | ||
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53 | Q29618277 | ||
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice | Q29618278 | ||
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents | Q31029469 | ||
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage | Q31160033 | ||
DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. | Q33210943 | ||
Phosphorylation of replication protein A by S-phase checkpoint kinases | Q33231615 | ||
DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation | Q33254931 | ||
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. | Q33288787 | ||
Human MRE11 is inactivated in mismatch repair-deficient cancers | Q33757629 | ||
Uracil in DNA--occurrence, consequences and repair | Q34165028 | ||
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis | Q34281241 | ||
Thymine starvation-induced structural changes in Escherichia coli DNA. Detection by pulsed field gel electrophoresis and evidence for involvement of homologous recombination | Q34326137 | ||
BRCA2: a universal recombinase regulator. | Q34655484 | ||
Induction of mitotic recombination in yeast by starvation for thymine nucleotides | Q36411499 | ||
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks | Q36686012 | ||
Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications | Q36720282 | ||
Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. | Q36981985 | ||
Uracil in DNA: consequences for carcinogenesis and chemotherapy | Q37206564 | ||
5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems | Q38295821 | ||
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. | Q38778670 | ||
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase. | Q40066683 | ||
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. | Q40127820 | ||
Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. | Q40291415 | ||
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency | Q40367703 | ||
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. | Q40478691 | ||
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts | Q40488070 | ||
5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells | Q40514711 | ||
Involvement of base excision repair in response to therapy targeted at thymidylate synthase | Q40542615 | ||
Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells | Q40667337 | ||
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells | Q41002866 | ||
Folate-based thymidylate synthase inhibitors in cancer chemotherapy. | Q41468166 | ||
Production of sister chromatid exchanges by various cancer chemotherapeutic agents | Q41486869 | ||
Induction of intrachromosomal recombination in yeast by inhibition of thymidylate biosynthesis | Q42959596 | ||
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition | Q44301722 | ||
Thymineless death in Escherichia coli mutants deficient in the RecF recombination pathway | Q46594672 | ||
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. | Q53590095 | ||
Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway. | Q54484239 | ||
Thymidylate stress induces homologous recombination activity in mammalian cells | Q54703498 | ||
DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells | Q64389343 | ||
Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase | Q80209002 | ||
P433 | issue | 8 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | DNA damage | Q5205747 |
P304 | page(s) | 987-996 | |
P577 | publication date | 2008-08-19 | |
P1433 | published in | Biochemical Pharmacology | Q864229 |
P1476 | title | DNA damage and homologous recombination signaling induced by thymidylate deprivation | |
P478 | volume | 76 |
Q41077343 | Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics. |
Q36432422 | Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination |
Q37041218 | Homologous Recombination Repair Polymorphisms and the Risk for Osteosarcoma |
Q37644861 | Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage |
Q37114275 | Participation of DNA repair in the response to 5-fluorouracil |
Q90787943 | Peptidomimetic Polo-Box targeted inhibitors that engage PLK1 in tumor cells and are selective against the PLK3 tumor suppressor |
Q85358088 | Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation |
Q34318584 | SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress |
Q43091367 | Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype |
Q47748271 | Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. |
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