AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling

scientific article published on September 2010

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2010.08.019
P932PMC publication ID2945612
P698PubMed publication ID20864035
P5875ResearchGate publication ID46413340

P50authorMatteo PellegriniQ41172848
P2093author name stringMichael A Teitell
John P Manis
Richard A Gatti
Ali I Kuraishy
Nicholas A Cacalano
Michael A Damore
Chetan Deshpande
Mara H Sherman
Jason S Hong
P2860cites workActivation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cellsQ24319096
Transcriptional analysis of the B cell germinal center reactionQ24554209
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesQ24644085
Immunoglobulin class switch recombination is impaired in Atm-deficient miceQ24647660
TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformationQ24674168
The RAG proteins and V(D)J recombination: complexes, ends, and transpositionQ28145648
Transcription-targeted DNA deamination by the AID antibody diversification enzymeQ28190732
DNA double-strand breaks: signaling, repair and the cancer connectionQ28204231
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression programQ28216493
Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascadeQ28250022
Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cellsQ28252567
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detectorQ28285140
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Cell-cycle checkpoints and cancerQ28293996
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingQ28366125
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Q28504452
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
Nibrin functions in Ig class-switch recombinationQ28594821
53BP1 is required for class switch recombinationQ29465541
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Q29465548
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectorsQ29547596
Metformin and reduced risk of cancer in diabetic patientsQ29616275
Somatic generation of antibody diversityQ29616439
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
Reverse engineering of regulatory networks in human B cellsQ30004211
Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.Q33818028
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissuesQ33934262
Immunodeficiency and infections in ataxia-telangiectasia.Q34311643
Mechanisms of chromosomal translocations in B cell lymphomasQ34405423
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiationQ34986627
The TCL1 family of oncoproteins: co-activators of transformationQ36213981
High affinity germinal center B cells are actively selected into the plasma cell compartment.Q36228042
Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.Q36369648
ATM is required for efficient recombination between immunoglobulin switch regionsQ36399334
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.Q36435300
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2Q36786810
IRF4 addiction in multiple myelomaQ36891060
Germinal centres: role in B-cell physiology and malignancyQ37039584
Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated geneQ37174163
LKB1; linking cell structure and tumor suppressionQ37333592
Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.Q39903195
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient miceQ39995270
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.Q40122149
BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cellsQ40377462
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.Q40457853
TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphomaQ40812531
Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomasQ40901168
Leukemia and lymphoma in ataxia telangiectasiaQ40941950
In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cellsQ40989631
Clonal selection and learning in the antibody systemQ41002744
LKB1: cancer, polarity, metabolism, and now fertilityQ41878804
H2AX prevents DNA breaks from progressing to chromosome breaks and translocationsQ46904251
BCL-6 expression during B-cell activationQ48063185
Generation of memory B cells and plasma cells in vitro.Q52053106
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.Q55034216
Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.Q55044565
Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissuesQ73726012
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in miceQ81747975
P433issue6
P921main subjectcell differentiationQ210861
genotoxicityQ1009245
P304page(s)873-885
P577publication date2010-09-01
P1433published inMolecular CellQ3319468
P1476titleAID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling
P478volume39

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cites work (P2860)
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Q35159001Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination
Q39322967V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity

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