The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin (scientific article)

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Q27323092	High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model
Q33499119	Histological evaluation of AMPK signalling in primary breast cancer
Q36716842	Hitting the mark in hamartoma syndromes.
Q37448058	Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.
Q35645142	Hormesis does not make sense except in the light of TOR-driven aging
Q37896899	Hormonal regulation of hepatic glucose production in health and disease
Q37597058	Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.
Q51752375	Hunting for the SNARK in metabolic disease.
Q42945769	Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling.
Q39781765	Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
Q89589757	Hypothalamic AMPK and energy balance
Q38166590	Hypoxia induced tumor metabolic switch contributes to pancreatic cancer aggressiveness.
Q33555596	Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist
Q37233462	Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis
Q92803859	Immunometabolic cross-talk in the inflamed heart
Q93378589	Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
Q35516372	Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs
Q40630534	Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects
Q28547202	In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus
Q33668408	In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.
Q35612115	In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase
Q39979957	In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.
Q54181531	Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report.
Q36964866	Incretin-based therapies in type 2 diabetes mellitus
Q92033421	Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice
Q27301386	Indirect effects of glucagon-like peptide-1 receptor agonist exendin-4 on the peripheral circadian clocks in mice
Q37142481	Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease
Q39578882	Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins
Q37087351	Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling
Q39001899	Inhibition of melanogenesis by the antidiabetic metformin
Q47438359	Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation
Q29619495	Insulin and insulin-like growth factor signalling in neoplasia
Q28072521	Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk
Q47551163	Intestinal Epithelial Cell-Derived LKB1 Suppresses Colitogenic Microbiota.
Q42801148	Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.
Q34291303	Involvement of SIK3 in glucose and lipid homeostasis in mice
Q35149589	Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy
Q34719522	Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress
Q47561333	Is Metformin Poised for a Second Career as an Antimicrobial?
Q40062822	Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome
Q33569838	Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase
Q60947803	Isoquercetin Improves Hepatic Lipid Accumulation by Activating AMPK Pathway and Suppressing TGF-β Signaling on an HFD-Induced Nonalcoholic Fatty Liver Disease Rat Model
Q28071388	Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives
Q91750405	Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers
Q46471150	KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops
Q37412793	KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity
Q35041508	Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue
Q36292001	Koschei the immortal and anti-aging drugs
Q37383513	LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
Q33919567	LKB1 and AMPK and the regulation of skeletal muscle metabolism
Q37543834	LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism
Q37724382	LKB1 and AMPK regulate synaptic remodeling in old age
Q35874238	LKB1 and Notch Pathways Interact and Control Biliary Morphogenesis
Q39026772	LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies
Q33583058	LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
Q42547962	LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
Q41712750	LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
Q40535121	LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
Q37829489	LKB1 loss of function studied in vivo
Q39051999	LKB1 promotes metabolic flexibility in response to energy stress.
Q41870049	LKB1 regulates pancreatic beta cell size, polarity, and function
Q37211374	LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.
Q37868986	LKB1 signaling in advancing cell differentiation
Q36808614	LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.
Q27315222	LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes
Q38718930	LKB1/AMPK pathway mediates resistin-induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes
Q37333592	LKB1; linking cell structure and tumor suppression
Q35163721	Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models
Q36418845	Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin
Q33602487	Leptin revisited: its mechanism of action and potential for treating diabetes
Q36710614	Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.
Q34995412	Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
Q34308013	Linking epigenetics to lipid metabolism: focus on histone deacetylases.
Q35905322	Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo
Q90193411	Liraglutide Inhibits Hepatitis C Virus Replication Through an AMP Activated Protein Kinase Dependent Mechanism
Q36255938	Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation
Q37276934	Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo
Q35002962	Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor κB (NF-κB) activation in macrophages
Q47108131	Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis
Q27335445	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
Q34690043	Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Q34679984	Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Q39076554	Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis.
Q103803522	Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
Q90453594	Long-term survival analysis of patients with non-small cell lung cancer complicated with type 2 diabetes mellitus
Q34602408	Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways
Q91000079	Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation
Q47439029	Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice
Q35720274	Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
Q33946957	Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).
Q64106705	Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism
Q36127217	Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells
Q28576369	MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1
Q47924673	Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis
Q36966996	Maternal cholestasis during pregnancy programs metabolic disease in offspring.
Q51155380	Maternal fructose intake during pregnancy modulates hepatic and hypothalamic AMP-activated protein kinase signalling in a sex-specific manner in offspring.
Q46375512	Maternal overnutrition suppresses the phosphorylation of 5'-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep
Q35022533	Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription
Q36301403	Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
Q34283475	Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors
Q34737010	Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
Q36734817	Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice
Q26827387	Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells
Q33851000	Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.
Q90176440	Metabolic Health, Insulin, and Breast Cancer: Why Oncologists Should Care About Insulin
Q98465694	Metabolic Pathways in Alloreactive T Cells
Q58728734	Metabolic Profiles Associated With Metformin Efficacy in Cancer
Q35161241	Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin?
Q35854516	Metabolic actions of hypothalamic SIRT1
Q54488583	Metabolic basis for thyroid hormone liver preconditioning: upregulation of AMP-activated protein kinase signaling.
Q47151991	Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.
Q37789697	Metabolic engineering of resveratrol and other longevity boosting compounds
Q28472728	Metabolic regulation of neuronal plasticity by the energy sensor AMPK
Q46213230	Metabolic targets for cancer therapy
Q26823745	Metabolism and breast cancer risk: frontiers in research and practice
Q91013837	Metabolism and mitochondria in polycystic kidney disease research and therapy
Q37083602	Metformin
Q22241787	Metformin -- life begins at 50: A symposium held on the occasion of the 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, The Netherlands, September 2007
Q90599508	Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
Q92141973	Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
Q28551227	Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
Q28547140	Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells
Q61797808	Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis
Q38740526	Metformin Elicits Antitumor Effects and Downregulates the Histone Methyltransferase Multiple Myeloma SET Domain (MMSET) in Prostate Cancer Cells
Q47796176	Metformin Exerts Beneficial Effects in Hemorrhagic Shock in an Ampkα1-Independent Manner
Q55081704	Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings.
Q38645850	Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency
Q51189895	Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Q35333423	Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis
Q42920181	Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial
Q38635672	Metformin Synergistically Potentiates the Antitumor Effects of Imatinib in Colorectal Cancer Cells
Q38740928	Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers
Q36000051	Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.
Q37680132	Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression
Q24617747	Metformin activates AMP kinase through inhibition of AMP deaminase
Q35055641	Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex
Q35534198	Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
Q48243268	Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Q64110666	Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport
Q60960582	Metformin alters H2A.Z dynamics and regulates androgen dependent prostate cancer progression
Q46362610	Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Q58572220	Metformin and Colorectal Cancer
Q95271395	Metformin and Its Benefits for Various Diseases
Q38819039	Metformin and Prostate Cancer: a New Role for an Old Drug.
Q35046074	Metformin and breast and gynecological cancer risk among women with diabetes
Q34159241	Metformin and cancer
Q41136911	Metformin and cancer: Technical and clinical implications for FDG-PET imaging
Q37837675	Metformin and cancer: new applications for an old drug
Q37417220	Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
Q28082736	Metformin and metabolic diseases: a focus on hepatic aspects
Q34196114	Metformin and other biguanides in oncology: advancing the research agenda
Q38689022	Metformin and pancreatic cancer: Is there a role?
Q34984314	Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
Q22241965	Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration
Q33668168	Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality
Q34554303	Metformin and sex: Why suppression of aging may be harmful to young male mice
Q64279473	Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells
Q38427103	Metformin and the risk of endometrial cancer: a case-control analysis
Q58698115	Metformin as a Therapeutic Target in Endometrial Cancers
Q41444311	Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes.
Q51062946	Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients.
Q37376404	Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.
Q39255557	Metformin confers risk reduction for developing hepatocellular carcinoma recurrence after liver resection
Q41897802	Metformin directly acts on mitochondria to alter cellular bioenergetics.
Q37365603	Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
Q91946347	Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial
Q53008100	Metformin effects on malignant cells and healthy PBMC; the influence of metformin on the phenotype of breast cancer cells.
Q35963205	Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial
Q55262517	Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response.
Q37151577	Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling
Q60914133	Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells
Q34424886	Metformin for aging and cancer prevention
Q39944738	Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.
Q41676510	Metformin for pancreatic cancer
Q37416813	Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder
Q36205053	Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.
Q38494077	Metformin improves postprandial glucose homeostasis in rainbow trout fed dietary carbohydrates: a link with the induction of hepatic lipogenic capacities?
Q38996447	Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial
Q37855307	Metformin in prostate cancer: two for the price of one.
Q39515437	Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells
Q37719411	Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.
Q28472548	Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Q33610569	Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones).
Q39595863	Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.
Q34547703	Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.
Q37205539	Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.
Q93136465	Metformin inhibits cervical cancer cell proliferation via decreased AMPK O-GlcNAcylation
Q36390358	Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats
Q34095221	Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus
Q64906844	Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Q36896122	Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.
Q36624074	Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase
Q35944480	Metformin inhibits growth of lung adenocarcinoma cells by inducing apoptosis via the mitochondria-mediated pathway
Q33968008	Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Q36262595	Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2).
Q37354549	Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
Q33914014	Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells.
Q37013230	Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression
Q36545664	Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
Q37463664	Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy
Q34505650	Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium
Q34104019	Metformin limits the adipocyte tumor-promoting effect on ovarian cancer.
Q34357952	Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers
Q91598281	Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells
Q37564694	Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP.
Q37522894	Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.
Q35877999	Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
Q41992046	Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis
Q37720435	Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats.
Q39370938	Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.
Q36194438	Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions
Q92087089	Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway
Q28485245	Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism
Q59882737	Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Q36998088	Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
Q39640373	Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
Q34065151	Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats
Q36724703	Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Q22251079	Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Q43116111	Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice
Q36729549	Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
Q46357678	Metformin suppresses intestinal polyp growth in ApcMin/+ mice
Q34044814	Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction.
Q53378831	Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Q37354564	Metformin targets c-MYC oncogene to prevent prostate cancer.
Q37609790	Metformin targets multiple signaling pathways in cancer
Q35034700	Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells
Q37262966	Metformin therapy and clinical uses
Q26850912	Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review
Q35064005	Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation
Q64940562	Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease.
Q37991589	Metformin use among individuals at risk for type 2 diabetes
Q90324219	Metformin use and incidence cancer risk: evidence for a selective protective effect against liver cancer
Q38734576	Metformin use and survival after non-small cell lung cancer: A cohort study in the US Military health system
Q56888943	Metformin use in the first year after kidney transplant, correlates, and associated outcomes in diabetic transplant recipients: A retrospective analysis of integrated registry and pharmacy claims data
Q39519100	Metformin, Diabetes, and Survival among U.S. Veterans with Colorectal Cancer
Q39707409	Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
Q35761000	Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers
Q34658712	Metformin--mode of action and clinical implications for diabetes and cancer
Q34714647	Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
Q42700292	Metformin: A Bridge between Diabetes and Prostate Cancer.
Q60939760	Metformin: A Candidate Drug for Renal Diseases
Q38756907	Metformin: A Hopeful Promise in Aging Research
Q94603091	Metformin: A Possible Option in Cancer Chemotherapy
Q36524748	Metformin: A candidate for the treatment of gynecological tumors based on drug repositioning
Q26999344	Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium
Q39100209	Metformin: New Preparations and Nonglycemic Benefits
Q37608817	Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
Q36026661	Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis
Q36715464	Metformin: an old but still the best treatment for type 2 diabetes
Q37530252	Metformin: do we finally have an anti-aging drug?
Q35764409	Metformin: multi-faceted protection against cancer
Q38584636	Metformin: risk-benefit profile with a focus on cancer
Q36109268	Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.
Q34345924	MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor
Q40555570	MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc
Q28554383	Miltefosine Suppresses Hepatic Steatosis by Activating AMPK Signal Pathway
Q42436880	Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.
Q41913553	Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage
Q33913626	Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice
Q33677858	Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase
Q28081657	Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Q36099352	Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase
Q22252798	Molecular mechanism of action of metformin: old or new insights?
Q28253823	Molecular mechanisms of cancer development in obesity
Q38628354	Molecular pathophysiology of hepatic glucose production
Q36862768	Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
Q64018937	Mécanisme d’action hépatique de la metformine dans le diabète de type 2
Q38954169	Nephroprotective Effects of Metformin in Diabetic Nephropathy.
Q26786307	Neuropharmacological Actions of Metformin in Stroke
Q34133091	Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons
Q37680251	Neuroprotective effect of osmotin against ethanol-induced apoptotic neurodegeneration in the developing rat brain
Q30244650	New Roles of Lkb1 in Regulating Adipose Tissue Development and Thermogenesis
Q39041261	New insights into the anti-diabetic actions of metformin: from the liver to the gut.
Q26778766	New mechanisms of metformin action: Focusing on mitochondria and the gut
Q27023545	New promises for metformin: advances in the understanding of its mechanisms of action
Q24628724	Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Q44748085	Non-esterified fatty acids activate the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes
Q28480452	Novel approach to meta-analysis of microarray datasets reveals muscle remodeling-related drug targets and biomarkers in Duchenne muscular dystrophy
Q47134563	Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.
Q39392234	Novel neo glycolipid: formulation into pegylated cationic liposomes and targeting of DNA lipoplexes to the hepatocyte-derived cell line HepG2.
Q33695751	Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.
Q26750875	Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
Q33919545	OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Q26771452	Obesity and cancer, a case for insulin signaling
Q37503147	Obesity related hyperinsulinaemia and hyperglycaemia and cancer development
Q64890350	Observational Studies on the Association Between Post-diagnostic Metformin Use and Survival in Ovarian Cancer: A Systematic Review and Meta-Analysis.
Q27010558	Old drug, new trick: repurposing metformin for gynecologic cancers?
Q39185452	Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.
Q37274568	Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
Q33410837	Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans
Q64923711	Orange is the new black: Kinases are the new master regulators of tumor suppression.
Q36347755	Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation
Q39804702	Osteoblast differentiation is functionally associated with decreased AMP kinase activity.
Q88024659	Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment
Q37070323	Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.
Q30440152	Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
Q50909328	PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors.
Q37974734	PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.
Q37032524	PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects
Q33668140	PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis
Q41982039	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
Q36014897	Paracrine and endocrine effects of adipose tissue on cancer development and progression
Q34449857	Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
Q37671282	Perivascular fat, AMP-activated protein kinase and vascular diseases.
Q37037509	Peroxisome proliferator-activated receptors and hepatitis C virus-induced insulin resistance
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P819	ADS bibcode	2005Sci...310.1642S
P356	DOI	10.1126/SCIENCE.1120781
P3181	OpenCitations bibliographic resource ID	1622673
P932	PMC publication ID	3074427
P698	PubMed publication ID	16308421
P5875	ResearchGate publication ID	7461327

P50	author	Lewis C. Cantley	Q5017731
		Ronald A. DePinho	Q7364619
		Nabeel Bardeesy	Q30004507
P2093	author name string	Marc Montminy
		Seung-Hoi Koo
		Reuben J. Shaw
		Debbie Vasquez
		Katja A. Lamia
P2860	cites work	Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade	Q21245891
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P433	issue	5754
P407	language of work or name	English	Q1860
P921	main subject	metformin	Q19484
		Glucose	Q37525
		Stk11	Q18254378
		CREB regulated transcription coactivator 2	Q21498168
		Protein kinase, AMP-activated, alpha 1 catalytic subunit	Q21498728
		Protein kinase, AMP-activated, alpha 2 catalytic subunit	Q21498733
		Serine/threonine kinase 11	Q21991188
P5008	on focus list of Wikimedia project	ScienceSource	Q55439927
P304	page(s)	1642–1646
P577	publication date	2005-12-09
P1433	published in	Science	Q192864
P1476	title	The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
P478	volume	310

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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