Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

scientific article published on 28 November 2015

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.6418
P932PMC publication ID4808039
P698PubMed publication ID26621849
P5875ResearchGate publication ID285542641

P2093author name stringHao Liu
Jian Wang
Min Deng
Min Liang
Xin Fu
Zhimin He
Boyun Shi
Xinke Zhou
Yuqin Chen
Jitao Chen
Gao Yi
Jifang Liu
Liangcai Chen
P2860cites workMetforminQ22250907
Recent developments in targeting carbonic anhydrase IX for cancer therapeuticsQ27013023
Anti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysisQ27306002
Targeting HIF-1 for cancer therapyQ27860504
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumptionQ28300415
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminQ28590162
Purification and characterization of hypoxia-inducible factor 1Q28678375
Targeting hypoxia in cancer therapyQ29615491
Metformin and reduced risk of cancer in diabetic patientsQ29616275
Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis.Q34114761
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.Q34182185
Metformin in cancer prevention and therapyQ34357983
Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cellsQ34487968
Effects of metformin on CD133+ colorectal cancer cells in diabetic patientsQ35053962
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activationQ35120687
Metformin Prevents Tobacco Carcinogen–Induced Lung TumorigenesisQ35333423
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic responseQ35600122
Targeting AMPK for cancer prevention and treatmentQ35781311
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapyQ36007805
AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cellQ36214450
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndromeQ37256834
Diabetes, metformin, and breast cancer in postmenopausal womenQ37303867
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR SignalingQ37474343
Hypoxia and hypoxia-inducible factors: master regulators of metastasisQ37801762
AMP-activated protein kinase and metabolic controlQ37864217
Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.Q38243373
Crosstalk between Mdm2, p53 and HIF1-α: distinct responses to oxygen stress and implications for tumour hypoxiaQ38247162
Metformin: from mechanisms of action to therapiesQ38279824
Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinomaQ38942795
Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repairQ39306592
GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesisQ39872802
Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levelsQ42809789
Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy responseQ44362277
Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathwayQ47685710
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.Q54631030
Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels?Q85659129
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
hypoxiaQ105688
P304page(s)873-884
P577publication date2015-11-28
P1433published inOncotargetQ1573155
P1476titleMetformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
P478volume7

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