AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell

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AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/15384047.2014.987021
P932PMC publication ID4622954
P698PubMed publication ID25456211

P2093author name stringGang Han
Kun Liu
Yidong Wang
Shaowen Guo
Hangjun Gong
P2860cites workThe antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivoQ39416862
Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancersQ39424350
Antisense inhibition of survivin expression as a cancer therapeuticQ39610362
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.Q40021818
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelinQ40033668
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.Q40143359
Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent processQ40404137
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesisQ40548006
Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cellsQ40581555
Effects of metformin on proliferation of human colon carcinoma cell line SW-480Q42919093
Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinaseQ43124196
Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.Q46065775
The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathyQ46157399
Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcriptionQ46427332
5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase TranslocationQ57800666
Diabetes and Cancer: A Consensus ReportQ62267706
Hallmarks of Cancer: The Next GenerationQ22252312
Cellular and molecular mechanisms of metformin: an overviewQ27013561
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinaseQ28251163
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.Q33251776
Standards of medical care in diabetes--2010.Q33554238
Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.Q33718914
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanismQ34525699
National outcomes after gastric resection for neoplasmQ34620161
Recent advances in multimodal treatment for gastric cancer: a reviewQ36112130
Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signalingQ37620713
Metformin: taking away the candy for cancer?Q37775372
Metformin is associated with improved survival in endometrial cancerQ38165601
Survivin beyond physiology: orchestration of multistep carcinogenesis and therapeutic potentialsQ38190309
Targeting apoptosis for anticancer therapyQ38214561
Differential effects of AMPK agonists on cell growth and metabolismQ38954598
P433issue1
P921main subjectmetforminQ19484
apoptotic processQ14599311
P304page(s)77-87
P577publication date2015-01-01
P1433published inCancer Biology and TherapyQ2544651
P1476titleAMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell
P478volume16

Reverse relations

cites work (P2860)
Q47126247Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug
Q42061952Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
Q35919503Correlation between survivin genetic polymorphisms and lung cancer susceptibility
Q37437550Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer
Q54977122Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis.
Q38931011Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis
Q49283314HDAC2 and HDAC5 Up-Regulations Modulate Survivin and miR-125a-5p Expressions and Promote Hormone Therapy Resistance in Estrogen Receptor Positive Breast Cancer Cells.
Q41050067Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice
Q61449086LINK-A lncRNA Promotes Proliferation and Inhibits Apoptosis of Mantle Cell Lymphoma Cell by Upregulating Survivin
Q37733068Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway
Q38740526Metformin Elicits Antitumor Effects and Downregulates the Histone Methyltransferase Multiple Myeloma SET Domain (MMSET) in Prostate Cancer Cells
Q36099266Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling
Q39933909Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
Q37697040Metformin enhances the radiosensitivity of human liver cancer cells to γ-rays and carbon ion beams
Q60911522Metformin induces apoptotic cytotoxicity depending on AMPK/PKA/GSK-3β-mediated c-FLIP degradation in non-small cell lung cancer
Q36346026Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin
Q52331264Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation.
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Q37733377New insight for metformin against bladder cancer
Q55125583Non-thermal plasma treatment improves chicken sperm motility via the regulation of demethylation levels.
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Q92015313Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways

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