Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

scientific article

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.422
P3181OpenCitations bibliographic resource ID248137
P932PMC publication ID3292895
P698PubMed publication ID22289741
P5875ResearchGate publication ID221791215

P50authorClaudiu T SupuranQ28211545
Jean-Yves WinumQ28321861
P2093author name stringShoukat Dedhar
Paul C. McDonald
P2860cites workThe prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/- chemotherapyQ24801373
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IXQ27657692
Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationshipsQ28115959
Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumoursQ28138058
The catalytic properties of human carbonic anhydrase IXQ28202087
Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ductsQ28203175
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancerQ28206439
A novel quasi-viral agent, MaTu, is a two-component systemQ28209256
Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinaseQ28216714
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segmentQ28247998
Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical CancerQ28250852
Carbonic anhydrases: novel therapeutic applications for inhibitors and activatorsQ28263238
Immunohistochemistry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacityQ28266273
Expression of MaTu-MN protein in human tumor cultures and in clinical specimensQ28268829
Why do cancers have high aerobic glycolysis?Q28290710
Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tractsQ28303168
Hypoxia-inducible expression of tumor-associated carbonic anhydrasesQ28647603
Targeting hypoxia in cancer therapyQ29615491
Prognostic relevance of carbonic anhydrase-IX in high-risk, early-stage cervical cancer: a Gynecologic Oncology Group studyQ30433038
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosisQ48678753
Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C.Q50095649
Brain phenotype of carbonic anhydrase IX-deficient mice.Q51010100
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.Q51864014
HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.Q51996253
A microenvironmental model of carcinogenesis.Q53326346
Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma.Q53541890
Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer.Q53580661
Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.Q54623823
Expression of carbonic anhydrase IX in mouse tissues.Q54700391
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinomaQ57377955
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell linesQ58863231
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervixQ59139010
Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidneyQ68974069
Anti-renal-cell carcinoma chimeric antibody G250 facilitates antibody-dependent cellular cytotoxicity with in vitro and in vivo interleukin-2-activated effectorsQ71542477
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitorsQ73351038
Carbonic anhydrase IX/G250/MN: a molecule too good to be true?Q80654070
Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancerQ81813519
Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancerQ82276673
Serum carbonic anhydrase IX during first-line therapy of ovarian cancerQ82407168
Serum carbonic anhydrase IX and its prognostic relevance in vulvar cancerQ83434526
Co-expression of Hif1alpha and CAIX is associated with poor prognosis in oral squamous cell carcinoma patientsQ84587308
Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.Q39782884
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivativesQ39823779
The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growthsQ39848831
PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell linesQ39864792
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.Q39899643
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitorsQ40133103
Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxiaQ40233525
The role of carbonic anhydrase IX overexpression in kidney cancerQ40347130
Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells.Q40449476
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.Q40489574
Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasionQ40519856
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9.Q40687152
Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferationQ42148565
Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotypeQ42508648
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.Q42723906
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.Q42747961
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar rangeQ42822569
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Q43004616
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumorsQ43276919
Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.Q43829352
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour modelQ43829857
Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancerQ44342278
Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody.Q44398207
Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imagingQ44477869
Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancerQ44620601
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-cateninQ44624407
Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186ReQ44762750
Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cellsQ44793166
Colocalization of carbonic anhydrase 9 expression and cell proliferation in human head and neck squamous cell carcinoma.Q45238896
A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patientsQ45250754
Carbonic anhydrase IX in bladder cancer: a diagnostic, prognostic, and therapeutic molecular markerQ46541391
Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomasQ47343703
Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial.Q47654612
Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tractQ47717968
Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinomaQ47887068
Expression of carbonic anhydrases IX and XII during mouse embryonic developmentQ30816333
Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technologyQ33540178
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosisQ33557891
Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded CompoundsQ33780700
Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancerQ33790591
Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.Q33818995
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancerQ33903731
Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9.Q34093272
A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinomaQ34111751
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progressionQ34192789
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.Q34808815
Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancerQ35608684
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.Q35746400
Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer.Q36610569
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.Q36732878
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.Q37081132
Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer.Q37141969
Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?Q37161440
Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumoursQ37330712
Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array studyQ37350764
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor targetQ37579348
Generating specificity and diversity in the transcriptional response to hypoxiaQ37626406
Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapyQ37723006
Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature, 2007 - 2009.Q37754473
Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic DomainQ37785571
pH control mechanisms of tumor survival and growthQ37790658
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulationQ37796596
Hypoxia and energetic tumour metabolismQ37809288
Interfering with pH regulation in tumours as a therapeutic strategyQ37933052
GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON.Q38602274
Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.Q39450874
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitorsQ39488612
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.Q39574525
Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasionQ39583766
Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells.Q39697199
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantineoplasticQ2853144
medical oncologyQ6050805
carbonic anhydraseQ284089
targeted therapyQ492646
neoplasmQ1216998
neoplasm antigensQ76832457
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)84-97
P577publication date2012-01-01
P1433published inOncotargetQ1573155
P1476titleRecent developments in targeting carbonic anhydrase IX for cancer therapeutics
P478volume3

Reverse relations

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