Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease

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Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4254/WJH.V6.I11.800
P932PMC publication ID4243154
P698PubMed publication ID25429318
P5875ResearchGate publication ID268877711

P50authorBong-Soo ChaQ61196432
P2093author name stringHye-Jin Yoon
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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver diseaseQ42654018
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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant miceQ28591122
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Nonalcoholic fatty liver diseaseQ29619354
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RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistanceQ33831780
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Diacylglycerol-mediated insulin resistanceQ34109119
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride SynthesisQ34112535
Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophagesQ34144580
Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophagesQ34150591
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver diseaseQ34357996
Exercise, GLUT4, and skeletal muscle glucose uptakeQ34360751
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetesQ34370790
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductantsQ34402690
Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress.Q34415177
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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitisQ34585893
Metformin--mode of action and clinical implications for diabetes and cancerQ34658712
High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trialQ42947254
Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized studyQ43152304
Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trialQ43265559
Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitisQ43269657
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesQ43552270
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistanceQ43687860
Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot studyQ43742730
Metformin in non-alcoholic steatohepatitis.Q43745120
Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patientsQ43840329
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetesQ43911547
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patientsQ44018167
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.Q44055110
Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver diseaseQ44080580
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitusQ44211004
Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat contentQ44328965
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.Q44398229
Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.Q44527604
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazoneQ44598595
Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath testQ44627897
Vitamin E treatment in pediatric obesity-related liver disease: a randomized studyQ44694111
Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitisQ44696111
Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patientsQ44723054
Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver diseaseQ44726439
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitisQ44749300
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytesQ44758408
Metformin in the treatment of patients with non-alcoholic steatohepatitisQ44778658
Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicityQ44887140
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitisQ45077756
Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes.Q45265355
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanismsQ45300618
The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver diseaseQ46328653
Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitisQ46418008
Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intakeQ46473255
Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver diseaseQ46506089
Effect of changes on body weight and lifestyle in nonalcoholic fatty liver diseaseQ46685325
Fatty liver and the metabolic syndrome among Shanghai adultsQ46841528
Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndromeQ46893987
Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight lossQ47417361
Effect of weight reduction on hepatic abnormalities in overweight patientsQ47440169
Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study.Q51500156
The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.Q51543925
Therapeutic effects of restricted diet and exercise in obese patients with fatty liver.Q51574619
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory PropertiesQ57244208
A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese ratsQ62563606
Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot studyQ71173357
Cilostazol, a selective type III phosphodiesterase inhibitor, decreases triglyceride and increases HDL cholesterol levels by increasing lipoprotein lipase activity in ratsQ74348132
Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activationQ34744890
Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trialsQ34781949
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trialQ35681885
Innate immunity in the liverQ36036373
Statins and hepatotoxicity: focus on patients with fatty liverQ36079406
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitisQ36168809
Efficacy of MK615 for the treatment of patients with liver disordersQ36175038
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant miceQ36451932
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesisQ36557194
Lipoprotein metabolism in nonalcoholic fatty liver diseaseQ36682138
SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signalingQ36728656
Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humansQ36867487
Biochemistry of oxidative stressQ36979661
Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatmentQ37051418
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerationsQ37228756
Metabolic disturbances in non-alcoholic fatty liver disease.Q37401367
Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1Q37541351
Pioglitazone: side effect and safety profileQ37696508
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connectionQ37739949
Endoplasmic Reticulum Stress and Inflammation in Obesity and DiabetesQ37784942
Alternative Macrophage Activation and MetabolismQ37804862
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitisQ37953770
Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatmentQ38020699
Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?Q38126549
Potential treatment of human nonalcoholic fatty liver disease with long-chain omega-3 polyunsaturated fatty acids.Q38154668
Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitisQ38308819
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibratesQ38316076
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver diseaseQ38358419
The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression.Q38445993
Dietary Monounsaturated Fatty Acids but not Saturated Fatty Acids Preserve the Insulin Signaling Pathway via IRS‐1/PI3K in Rat Skeletal MuscleQ38480508
Up-regulation of hepatic low-density lipoprotein receptor-related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl-coenzyme A reductase inhibitor Atorvastatin and hepatic LRP1 expression.Q38480622
Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment.Q38489233
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved ratsQ38576885
P433issue11
P921main subjectliver diseaseQ929737
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
non-alcoholic fatty liverQ66299798
P304page(s)800-811
P577publication date2014-11-01
P1433published inWorld Journal of HepatologyQ27723328
P1476titlePathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
P478volume6

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