| Q37227510 | A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. |
| Q46775808 | A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance |
| Q35630807 | A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism |
| Q36616554 | AMP-activated protein kinase: Role in metabolism and therapeutic implications |
| Q54199151 | AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response. |
| Q51666922 | Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto-Kakizaki Rat: A Model for Non-Obese Type 2 Diabetes. |
| Q51246185 | Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets. |
| Q28576904 | Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease |
| Q35675775 | Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. |
| Q34362178 | Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity |
| Q36920864 | Adipokines mediate inflammation and insulin resistance |
| Q34496620 | Adipokines: a link between obesity and dementia? |
| Q38286500 | Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality |
| Q37271252 | Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones |
| Q51391222 | Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. |
| Q38349186 | Akt2 is required for hepatic lipid accumulation in models of insulin resistance. |
| Q64377408 | Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice |
| Q59791348 | An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma |
| Q35422218 | Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines. |
| Q30485410 | Association of hepatitis C virus with insulin resistance: evidences from animal studies and clinical studies |
| Q55436860 | BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver. |
| Q38341518 | Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programs |
| Q35022545 | Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes |
| Q33734679 | Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis |
| Q33785270 | Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c |
| Q47703395 | Biochemical and cellular properties of insulin receptor signalling |
| Q52717816 | CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting. |
| Q33633152 | Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription |
| Q37388544 | Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. |
| Q24564225 | Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse |
| Q37395843 | ChREBP regulates fructose-induced glucose production independently of insulin signaling |
| Q34508933 | Changes of hepatic biochemical parameters and proteomics in broilers with cold-induced ascites |
| Q24598294 | Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs |
| Q37420502 | Clinical Significance of Determining Plasma MicroRNA33b in Type 2 Diabetic Patients with Dyslipidemia |
| Q25255682 | Combined expression trait correlations and expression quantitative trait locus mapping |
| Q46222194 | Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs |
| Q36513449 | Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet |
| Q28508811 | Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver |
| Q33830715 | Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism |
| Q31032454 | Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts |
| Q88064814 | Curcumin and dietary polyphenol research: beyond drug discovery |
| Q36800168 | De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose |
| Q43215288 | Deepure Tea Improves High Fat Diet-Induced Insulin Resistance and Nonalcoholic Fatty Liver Disease |
| Q47875169 | Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis |
| Q28577995 | Desaturase activities in rat model of insulin resistance induced by a sucrose‐rich diet |
| Q80085805 | Development of type 2 diabetes in children and adolescents |
| Q38653024 | Developmental and extrahepatic physiological functions of SREBP pathway genes in mice |
| Q50420689 | Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease. |
| Q35139885 | Diabetic dyslipidaemia: from basic research to clinical practice. |
| Q53698117 | Diabetic ketoacidosis and severe hypertriglyceridaemia as a consequence of an atypical antipsychotic agent. |
| Q37326316 | Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. |
| Q34212919 | Dietary fat modifies lipid metabolism in the adipose tissue of metabolic syndrome patients. |
| Q40987059 | Dietary restriction, caloric value and the accumulation of hepatic fat. |
| Q37330407 | Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity |
| Q34618149 | Dimension reduction for mapping mRNA abundance as quantitative traits. |
| Q43848640 | Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c |
| Q34370965 | Disordered lipid metabolism and the pathogenesis of insulin resistance |
| Q38320716 | Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors |
| Q37155389 | Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs |
| Q34945194 | Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism |
| Q24564844 | Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes |
| Q33746400 | Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling |
| Q37033133 | E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis. |
| Q33824420 | Effect of diacylglycerol acyltransferase 2 overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation |
| Q37326288 | Effects of Medicinal herb Extracts and their Components on Steatogenic Hepatotoxicity in Sk-hep1 Cells |
| Q34113192 | Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance |
| Q33810241 | Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease |
| Q33727061 | Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus |
| Q36712005 | Effects on high cholesterol-fed to liver, retina, hippocampus, and Harderian gland in Goto-Kakizaki rat. |
| Q36049525 | Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency |
| Q35781449 | Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. |
| Q34102090 | Ethnicity and type 2 diabetes: focus on Asian Indians |
| Q38349579 | Expression Profiling Identifies Genes That Continue to Respond to Insulin in Adipocytes Made Insulin-resistant by Treatment with Tumor Necrosis Factor-α |
| Q34138315 | Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling |
| Q36118732 | Fatty acids and the metabolic syndrome |
| Q90458257 | Free fatty acid processing diverges in human pathologic insulin resistance conditions |
| Q35078197 | From gallstones to genes: two hundred years of sterol research. A tribute to George J. Schroepfer Jr. |
| Q37596560 | From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis |
| Q34117313 | Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance |
| Q42175294 | Fructose only in pregnancy provokes hyperinsulinemia, hypoadiponectinemia, and impaired insulin signaling in adult male, but not female, progeny. |
| Q37170811 | GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice |
| Q33867059 | Genetic control of de novo lipogenesis: role in diet-induced obesity |
| Q37267076 | Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice |
| Q42827141 | Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel |
| Q38660834 | Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes |
| Q47096026 | Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. |
| Q84008571 | Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? |
| Q64096707 | Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism |
| Q37665444 | Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins |
| Q34609585 | Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis |
| Q36060375 | Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression |
| Q37143361 | Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice |
| Q42413165 | Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity |
| Q33547349 | Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. |
| Q37980432 | Hepatitis C virus induced insulin resistance impairs response to anti viral therapy |
| Q34380511 | Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas |
| Q39377977 | Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance |
| Q91635299 | Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression |
| Q43135202 | High- or low-carbohydrate diets: which is better for weight loss, insulin resistance, and fatty livers? |
| Q50199746 | Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer |
| Q33945101 | Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease |
| Q46469535 | Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse |
| Q90457710 | Hyperinsulinaemia: does it tip the balance toward intrahepatic fat accumulation? |
| Q35064323 | Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor |
| Q44688376 | Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance. |
| Q39651056 | Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. |
| Q33812148 | Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization |
| Q43579821 | In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue |
| Q37087710 | Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice |
| Q38297185 | Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver |
| Q46326061 | Increased hepatic lipogenesis in insulin resistance and Type 2 diabetes is associated with AMPK signalling pathway up-regulation in Psammomys obesus |
| Q46288483 | Increased lipid synthesis and decreased β-oxidation in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model of metabolic syndrome |
| Q34430237 | Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice |
| Q28729212 | Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice |
| Q40753400 | Insig: a significant integrator of nutrient and hormonal signals |
| Q40816264 | Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*. |
| Q64276655 | Insulin and Insulin Receptors in Adipose Tissue Development |
| Q33808713 | Insulin and glucagon regulate pancreatic α-cell proliferation |
| Q90099963 | Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes |
| Q34321195 | Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins |
| Q36421247 | Insulin dependent apolipoprotein B degradation and phosphatidylinositide 3-kinase activation with microsomal translocation are restored in McArdle RH7777 cells following serum deprivation |
| Q35038803 | Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes |
| Q33730511 | Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells |
| Q40547543 | Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes |
| Q36160709 | Insulin resistance and steatosis in hepatitis C virus infection. |
| Q37408230 | Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism |
| Q37351598 | Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations |
| Q36342908 | Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase |
| Q35037837 | Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. |
| Q27334742 | Insulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liver |
| Q33952316 | Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions |
| Q33865202 | Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination |
| Q34339449 | Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. |
| Q41036138 | Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes |
| Q34955753 | Investigations of apoC-III metabolism using stable isotopes: what information can you acquire and how can you interpret your results? |
| Q27478049 | Involvement of the PA28 -Dependent Pathway in Insulin Resistance Induced by Hepatitis C Virus Core Protein |
| Q53731840 | Iron deficiency anemia and glucose metabolism. |
| Q34722653 | Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance |
| Q33673882 | LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size |
| Q24620780 | Leptin therapy in insulin-deficient type I diabetes |
| Q50257235 | Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". |
| Q35967247 | Lipid-induced insulin resistance in the liver: role of exercise |
| Q35078482 | Lipoatrophic diabetes and other related syndromes |
| Q35515576 | Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation. |
| Q44133905 | Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes |
| Q46888113 | Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice. |
| Q37105304 | Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress |
| Q34171384 | Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass |
| Q24554492 | Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis |
| Q36847534 | Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis |
| Q37308701 | Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance |
| Q33420823 | Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice |
| Q37530120 | MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q35743894 | Metabolic consequences of ENPP1 overexpression in adipose tissue. |
| Q39225251 | Metformin Reduces Lipogenesis Markers in Obese Mice Fed a Low-Carbohydrate and High-Fat Diet |
| Q22242637 | Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial |
| Q37036352 | MicroRNA 33 regulates glucose metabolism. |
| Q33833503 | Misconceptions about fructose-containing sugars and their role in the obesity epidemic |
| Q37320290 | Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila |
| Q37015037 | Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high-fat diet-fed transgenic mice |
| Q38569945 | Molecular mechanisms of fatty liver in obesity |
| Q37171127 | Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy |
| Q27489665 | Molecular mechanisms of insulin resistance in chronic hepatitis C |
| Q35163496 | Monocyte chemoattractant protein 1 in obesity and insulin resistance |
| Q53626088 | Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice. |
| Q40413498 | Mosaic analysis of insulin receptor function |
| Q36099612 | NOX4 pathway as a source of selective insulin resistance and responsiveness |
| Q24648189 | Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance |
| Q36343495 | New insight into the pathophysiology of lipid abnormalities in type 2 diabetes |
| Q34682304 | New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c |
| Q28203726 | New perspectives into the molecular pathogenesis and treatment of type 2 diabetes |
| Q37149405 | Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment |
| Q92564275 | Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action |
| Q89002575 | Obstructive Sleep Apnoea and Type 2 Diabetes |
| Q26999248 | Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism |
| Q46180287 | Obstructive sleep apnea and dyslipidemia: importance of the liver axis |
| Q83219069 | Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells |
| Q35000376 | Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages |
| Q43879860 | Organophosphorus insecticide, monocrotophos, possesses the propensity to induce insulin resistance in rats on chronic exposure |
| Q24631468 | Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis |
| Q38305102 | Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c |
| Q90427915 | PAS Kinase deficiency alters the glucokinase function and hepatic metabolism |
| Q34433146 | PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells |
| Q28587145 | PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling |
| Q47379434 | PKC-β activation and pharmacologically induced weight gain during antipsychotic treatment |
| Q28582308 | PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity |
| Q36618518 | PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. |
| Q35015769 | PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans |
| Q33968441 | PTEN expression causes feedback upregulation of insulin receptor substrate 2 |
| Q38354027 | PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat. |
| Q34449857 | Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease |
| Q35662330 | Pathogenesis of selective insulin resistance in isolated hepatocytes |
| Q34155467 | Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state |
| Q48370446 | Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha |
| Q38289039 | Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin |
| Q34882666 | Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. |
| Q42804994 | Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells |
| Q37736477 | Physiological insights gained from gene expression analysis in obesity and diabetes |
| Q42140910 | Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation |
| Q37073732 | Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis |
| Q38119865 | Potential mechanisms of atypical antipsychotic-induced hypertriglyceridemia |
| Q37389108 | Prenatal exposure to undernutrition and programming of responses to high-fat feeding in the rat. |
| Q24815863 | Prevalence, predisposition and prevention of type II diabetes |
| Q30557551 | Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance |
| Q37402142 | Promoting longevity by maintaining metabolic and proliferative homeostasis |
| Q39735993 | Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin. |
| Q28570423 | Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression |
| Q36417824 | Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. |
| Q91635371 | Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways |
| Q34685308 | Reconstitution of insulin action in muscle, white adipose tissue, and brain of insulin receptor knock-out mice fails to rescue diabetes |
| Q35121079 | Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure |
| Q38876354 | Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling. |
| Q35858148 | Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice |
| Q42825786 | Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. |
| Q52017178 | Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet. |
| Q28566684 | Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes |
| Q24814568 | Reversal of high dietary fructose-induced PPARalpha suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors |
| Q49723467 | Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins. |
| Q55278642 | Rho, a Fraction From Rhodiola crenulate, Ameliorates Hepatic Steatosis in Mice Models. |
| Q39933737 | Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors. |
| Q42247586 | Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription |
| Q22241898 | Role of AMP-activated protein kinase in mechanism of metformin action |
| Q26749020 | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
| Q35794774 | Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9. |
| Q37365468 | Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice |
| Q28568969 | Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance |
| Q36020648 | Role of the liver in the control of carbohydrate and lipid homeostasis |
| Q36962066 | Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance. |
| Q26821934 | Roles of renal proximal tubule transport in acid/base balance and blood pressure regulation |
| Q28365331 | SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation |
| Q44308547 | SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes |
| Q36728656 | SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling |
| Q58114538 | SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction |
| Q29547646 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver |
| Q35886299 | Scap is required for sterol synthesis and crypt growth in intestinal mucosa |
| Q28078342 | Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease |
| Q34274838 | Scientific side trips: six excursions from the beaten path |
| Q26744243 | Selective Insulin Resistance in the Kidney |
| Q53689223 | Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. |
| Q37076798 | Selective versus total insulin resistance: a pathogenic paradox |
| Q28468525 | Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor |
| Q38082482 | Severe hypertriglyceridaemia in Type 2 diabetes mellitus: beneficial effect of continuous insulin infusion |
| Q36485655 | Signalling mechanisms linking hepatic glucose and lipid metabolism |
| Q35631912 | Site and mechanism of leptin action in a rodent form of congenital lipodystrophy |
| Q90483960 | Skeletal muscle autophagy remains responsive to hyperinsulinemia and hyperglycemia at higher plasma insulin concentrations in insulin-resistant mice |
| Q35224775 | Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases |
| Q34989773 | Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids |
| Q33907632 | Steatosis and steatohepatitis: complex disorders |
| Q58045882 | Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice |
| Q37431796 | Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity |
| Q28586863 | Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms |
| Q33716026 | Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats |
| Q89149074 | Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease |
| Q73201102 | T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects |
| Q34357938 | The A2b adenosine receptor modulates glucose homeostasis and obesity |
| Q52661639 | The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. |
| Q41763683 | The Effects of Insulin Resistance on Individual Tissues: An Application of a Mathematical Model of Metabolism in Humans. |
| Q35623077 | The Regulation of Lipid Deposition by Insulin in Goose Liver Cells Is Mediated by the PI3K-AKT-mTOR Signaling Pathway |
| Q36329899 | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
| Q34412580 | The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice |
| Q24654991 | The blind men 'see' the elephant-the many faces of fatty liver disease |
| Q33449878 | The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis |
| Q34428352 | The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells |
| Q51245857 | The hepatic ectonucleotide pyrophosphatase/phosphodiesterase 1 gene mRNA abundance is reduced by insulin and induced by dexamethasone. |
| Q35990066 | The impact of host factors on management of hepatitis C virus |
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