| scholarly article | Q13442814 |
| P2093 | author name string | J Li | |
| R Parsons | |||
| L Simpson | |||
| D Liaw | |||
| I Hennessy | |||
| F Christians | |||
| J Oliner | |||
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| Direct control of the Forkhead transcription factor AFX by protein kinase B | Q22009452 | ||
| Phosphorylation of the PTEN tail regulates protein stability and function | Q22254305 | ||
| Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| A simplified system for generating recombinant adenoviruses | Q24682328 | ||
| Regulation of p53 stability by Mdm2 | Q27860744 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice | Q28144106 | ||
| PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma | Q28279165 | ||
| The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
| PTEN/MMAC1 mutations in endometrial cancers. | Q53439663 | ||
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies | Q57591287 | ||
| Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins | Q70787161 | ||
| Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function | Q73019421 | ||
| PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death | Q73229813 | ||
| Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies | Q73722520 | ||
| Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains | Q73881073 | ||
| Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction | Q74191142 | ||
| The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene | Q77726383 | ||
| 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice | Q28289491 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Expression cloning of protein targets for 3-phosphorylated phosphoinositides | Q28377996 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
| A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling | Q28609913 | ||
| The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway | Q28611339 | ||
| A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory | Q28645870 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 | Q29615851 | ||
| Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. | Q30714274 | ||
| Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway | Q30829981 | ||
| The role of phosphoinositide 3-kinase lipid products in cell function | Q33543235 | ||
| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells | Q33586807 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity | Q33774967 | ||
| The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. | Q33783562 | ||
| Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene | Q35063217 | ||
| Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis | Q35250337 | ||
| The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway | Q36396479 | ||
| Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. | Q37174878 | ||
| Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice | Q40019067 | ||
| A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. | Q40875073 | ||
| The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells | Q40993616 | ||
| Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. | Q41028627 | ||
| Phosphoinositide 3-kinase and the regulation of cell growth | Q41078881 | ||
| Insulin and insulin-like growth factor signaling are defective in the MDA MB-468 human breast cancer cell line | Q41439731 | ||
| The IRS-signalling system during insulin and cytokine action | Q41516480 | ||
| Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway | Q41616329 | ||
| Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation | Q41709294 | ||
| Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit | Q42066856 | ||
| Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins | Q42160084 | ||
| Expression and function of IRS-1 in insulin signal transmission. | Q42455127 | ||
| Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. | Q42801480 | ||
| Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways | Q47070325 | ||
| PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. | Q47072188 | ||
| Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. | Q48331127 | ||
| The taxonomy of developmental control in Caenorhabditis elegans | Q48765830 | ||
| Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells | Q50336672 | ||
| Negative regulation of the forkhead transcription factor FKHR by Akt. | Q52535267 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 3947-3958 | |
| P577 | publication date | 2001-06-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | PTEN expression causes feedback upregulation of insulin receptor substrate 2 | |
| P478 | volume | 21 |
| Q44283207 | Activation of PPARgamma increases PTEN expression in pancreatic cancer cells |
| Q35642171 | Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA. |
| Q40615998 | Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese population |
| Q36384467 | Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis |
| Q79098518 | Constipation, polyps, or cancer? let PTEN predict your future |
| Q40583820 | Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals |
| Q36046827 | Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection |
| Q38924965 | Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ. |
| Q37073819 | Irs2 inactivation suppresses tumor progression in Pten+/- mice |
| Q40135925 | Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling. |
| Q40627561 | LysB3, GluB29 insulin: a novel insulin analog with enhanced β-cell protective action |
| Q34096820 | Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes |
| Q36199762 | Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer |
| Q34540849 | PTEN: The down side of PI 3-kinase signalling. |
| Q28203387 | PTEN: one gene, many syndromes |
| Q46709687 | Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis |
| Q42804994 | Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells |
| Q37403974 | Phosphorylation of IRS proteins Yin-Yang regulation of insulin signaling |
| Q41979754 | Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes |
| Q44230853 | Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade |
| Q40618771 | Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells |
| Q36832185 | Survival factor NFIL3 restricts FOXO-induced gene expression in cancer |
| Q36421389 | Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death |
| Q35976355 | The complexity of PTEN: mutation, marker and potential target for therapeutic intervention |
| Q44319782 | Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling |
| Q36323481 | p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase |
| Q39820138 | p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. |
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