| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1517/14728222.8.6.537 |
| P698 | PubMed publication ID | 15584861 |
| P50 | author | James A. McCubrey | Q42317570 |
| Linda S Steelman | Q114723345 | ||
| P2093 | author name string | Fred E Bertrand | |
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas | Q24294176 | ||
| Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1 | Q24304322 | ||
| The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover | Q35717575 | ||
| Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways | Q36256326 | ||
| Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. | Q40587498 | ||
| Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation | Q40657196 | ||
| PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway | Q40736882 | ||
| PTEN gene mutations in colorectal cancers displaying microsatellite instability | Q40771097 | ||
| Chemosensitivity of prostate cancer cell lines and expression of multidrug resistance-related proteins | Q40797044 | ||
| mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer | Q42660087 | ||
| PTEN: sometimes taking it off can be better than putting it on. | Q43104730 | ||
| PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression | Q43701623 | ||
| Promoter methylation and silencing of PTEN in gastric carcinoma | Q43918868 | ||
| Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions | Q44467149 | ||
| A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells | Q44714283 | ||
| Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation | Q45345194 | ||
| Silencing of thePTENtumor-suppressor gene in anaplastic thyroid cancer | Q57591241 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism | Q24603034 | ||
| Protean PTEN: form and function | Q24613810 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway | Q28139300 | ||
| PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model | Q28202775 | ||
| PTEN: one gene, many syndromes | Q28203387 | ||
| Caveolin-1, a putative tumour suppressor gene | Q28212075 | ||
| A highly conserved processed PTEN pseudogene is located on chromosome band 9p21 | Q28273178 | ||
| Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase | Q28567492 | ||
| A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling | Q28609913 | ||
| Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. | Q29568322 | ||
| Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis | Q31533805 | ||
| PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways | Q31837554 | ||
| PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model | Q32069431 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| Hypermethylation of tumor suppressor genes in cancer | Q33765677 | ||
| The multiple roles of PTEN in tumor suppression | Q33849727 | ||
| An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice | Q33943166 | ||
| PTEN expression causes feedback upregulation of insulin receptor substrate 2 | Q33968441 | ||
| HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression | Q33968465 | ||
| Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex | Q34101673 | ||
| Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. | Q34184917 | ||
| Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. | Q34318634 | ||
| Interplay between insulin and nutrients in the regulation of translation factors | Q34332477 | ||
| Biological role of phosphatase PTEN in cancer and tissue injury healing | Q34625808 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma | Q34890267 | ||
| Clinical development of mammalian target of rapamycin inhibitors | Q35038759 | ||
| Novel germline mutation of the PTEN gene in a Japanese family with Cowden disease | Q35057566 | ||
| Genetic markers in glioblastoma: prognostic significance and future therapeutic implications | Q35162757 | ||
| JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis | Q35635353 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 537-550 | |
| P577 | publication date | 2004-12-01 | |
| P1433 | published in | Expert Opinion on Therapeutic Targets | Q5421214 |
| P1476 | title | The complexity of PTEN: mutation, marker and potential target for therapeutic intervention | |
| P478 | volume | 8 |
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| Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
| Q26863333 | Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor |
| Q37109227 | Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. |
| Q35640301 | Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells |
| Q28297001 | Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse |
| Q39210082 | Effect of PTEN antisense oligonucleotide on oesophageal squamous cell carcinoma cell lines |
| Q37691441 | Emerging MEK inhibitors. |
| Q38180344 | Emerging roles of radioresistance in prostate cancer metastasis and radiation therapy |
| Q42951206 | Expression and clinical significance of mTOR and PTEN in non-small cell lung cancer |
| Q52731993 | Extracting Fitness Relationships and Oncogenic Patterns among Driver Genes in Cancer. |
| Q37452775 | Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer |
| Q46845164 | Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients |
| Q83937839 | Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis |
| Q91611008 | Identification of key pathways and genes in PTEN mutation prostate cancer by bioinformatics analysis |
| Q45791565 | Impaired phosphate and tension homologue deleted on chromosome 10 expression and its prognostic role in radical surgery for hepatocellular carcinoma with family aggregation resulting from hepatitis B and liver cirrhosis. |
| Q45758375 | Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells |
| Q35556981 | Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells |
| Q35640228 | Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy |
| Q54594563 | Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway. |
| Q42040007 | Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain. |
| Q28085250 | MicroRNAs in the pathobiology of sarcomas |
| Q33480331 | Molecular fingerprinting of radiation resistant tumors: can we apprehend and rehabilitate the suspects? |
| Q36862768 | Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response |
| Q47956518 | Notch signaling pathway and gene expression profiles during early in vitro differentiation of liver-derived mesenchymal stromal cells to osteoblasts. |
| Q36829487 | Oxidative stress mediates radiation lung injury by inducing apoptosis. |
| Q36461618 | Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
| Q42014039 | Preclinical Remodeling of Human Prostate Cancer through the PTEN/AKT Pathway. |
| Q47635358 | Pten regulates neural crest proliferation and differentiation during mouse craniofacial development |
| Q35964863 | Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism |
| Q45882545 | Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D. |
| Q34966603 | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging |
| Q24645668 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance |
| Q37331720 | Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. |
| Q37109225 | Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. |
| Q40154931 | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. |
| Q39638171 | Targeting the cancer initiating cell: The Achilles’ heel of cancer |
| Q34173253 | Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway |
| Q39112597 | The anti-chemoresistant effect and mechanism of MUC1 aptamer-miR-29b chimera in ovarian cancer |
| Q36268324 | The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? |
| Q36219713 | The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck. |
| Q37837732 | Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. |
| Q37034487 | Understanding signaling cascades in melanoma |
| Q38704894 | Upregulation of microrna-451 increases the sensitivity of A549 cells to radiotherapy through enhancement of apoptosis |
| Q50878323 | [Analysis of Efficacy of Surgical Treatment for IIIa Small Cell Lung Cancer]. |
| Q54546623 | mTOR and PTEN expression in non-small cell lung cancer: analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry. |
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