Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

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Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM1349
P698PubMed publication ID16474401
P5875ResearchGate publication ID7303045

P2093author name stringLei Li
Yun Zhang
Xia Zhang
Wen Jiang
Qi Wan
Shao-Ping Ji
Mingxia Liao
Jamie Van Cleemput
Jon R Backstrom
P2860cites workPTEN regulation of neural development and CNS stem cellsQ35014232
Therapeutic potential of 5-HT2C receptor antagonists in the treatment of anxiety disordersQ35610620
Historical review: Molecular and cellular mechanisms of opiate and cocaine addictionQ35737644
The complexity of PTEN: mutation, marker and potential target for therapeutic interventionQ35976355
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological studyQ42492989
Susceptibility to kindling and neuronal connections of the anterior claustrum.Q43594265
Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoidsQ44051647
mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acidsQ44084728
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactionsQ44193907
Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but not dorsal hippocampus.Q44838514
Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in ratsQ45180317
Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptorsQ48149092
Opioids excite dopamine neurons by hyperpolarization of local interneuronsQ48543154
Generation of anti-peptide antibodies against serotonin 5-HT2A and 5-HT2C receptorsQ48583781
Dorsal hippocampal kindling produces a selective and enduring disruption of hippocampally mediated behavior.Q48673238
Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the ratQ60054744
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
Marijuana and cannabinoid regulation of brain reward circuitsQ24671514
Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responsesQ28144632
A role for nuclear PTEN in neuronal differentiation.Q29568319
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.Q29568322
In vivo protein transduction: delivery of a biologically active protein into the mouseQ29615482
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Serotonin and drug reward: focus on 5-HT2C receptorsQ34277384
Role of serotonin(2C) receptors in the control of brain dopaminergic functionQ34558814
Molecular characterization of a functional cDNA encoding the serotonin 1c receptorQ34688040
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)324-9
P577publication date2006-03-01
P1433published inNature MedicineQ1633234
P1476titleDisruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
P478volume12

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cites work (P2860)
Q339368955-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway
Q380371415-HT2 ligands in the treatment of anxiety and depression
Q381090325-HT2 receptors-mediated modulation of voltage-gated K+ channels and neurophysiopathological correlates.
Q34206821A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference.
Q30494861A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN
Q39164871A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment
Q36937876Advances in behavioral genetics: mouse models of autism
Q64268723Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology
Q36562166CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc
Q37760048Cannabinoid conditioned reward and aversion: behavioral and neural processes.
Q39977932Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes
Q38445977Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice
Q34618432Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine
Q37007270Dose-dependent protective effect of bisperoxovanadium against acute cerebral ischemia in a rat model of ischemia/reperfusion injury
Q38820699Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction
Q37442718Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma
Q35072763Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications
Q48656806Functional Selectivity and Biased Receptor Signaling
Q37790693G protein coupled receptors as allosteric proteins and the role of allosteric modulators
Q28508076Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior
Q90049870In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog
Q31055274Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection
Q36798747Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
Q28384823NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
Q35128324Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability
Q27319930Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory
Q49550289PTEN Inhibition in Human Disease Therapy
Q38406254PTEN: a yin-yang master regulator protein in health and disease
Q37014106Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.
Q30493133Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
Q47330880Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice
Q35073513Plasticity of addiction: a mesolimbic dopamine short-circuit?
Q46978123Plot against pot.
Q37642472Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses
Q38450750Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests
Q28581295Requirement for the endocannabinoid system in social interaction impairment induced by coactivation of dopamine D1 and D2 receptors in the piriform cortex
Q47588598Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists
Q33502757Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons
Q91272443Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro
Q38113111Serotonin2C receptors and drug addiction: focus on cocaine
Q33890786Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery
Q38081692Signalling bias in new drug discovery: detection, quantification and therapeutic impact.
Q35755900Social Behavioral Deficits Coincide with the Onset of Seizure Susceptibility in Mice Lacking Serotonin Receptor 2c.
Q39774233Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
Q28476578Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning
Q34994532Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling
Q34655896The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues
Q36977930The Varied Uses of Conditioned Place Preference in Behavioral Neuroscience Research: An Investigation of Alcohol Administration in Model Organisms
Q34402658The potential for selective pharmacological therapies through biased receptor signaling
Q37345260The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors
Q37121500The role of the dorsal raphé nucleus in reward-seeking behavior
Q34546304The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens
Q35763142Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

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