Functional Selectivity and Biased Receptor Signaling

scientific article published on October 28, 2010

Functional Selectivity and Biased Receptor Signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1124/JPET.110.173948
P953full work available online athttp://intl-jpet.aspetjournals.org/cgi/content/abstract/336/2/296
https://syndication.highwire.org/content/doi/10.1124/jpet.110.173948
P698PubMed publication ID21030484

P2093author name stringTerry Kenakin
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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.Q33779634
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discoveryQ33890786
Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.Q34134694
AripiprazoleQ34203550
Efficacy as a vector: the relative prevalence and paucity of inverse agonismQ34289691
Agonist-receptor efficacy. II. Agonist trafficking of receptor signalsQ34304785
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.Q34536660
An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalizationQ34580057
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.Q34588487
Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevanceQ34650437
Beta-arrestin-biased ligands at seven-transmembrane receptorsQ34654662
The role of incretins in glucose homeostasis and diabetes treatmentQ34901533
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytesQ35133773
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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signalingQ36082162
Multiple signaling states of G-protein-coupled receptorsQ36138102
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptorsQ36160942
New concepts in drug discovery: collateral efficacy and permissive antagonismQ36303814
When 7 transmembrane receptors are not G protein-coupled receptorsQ36308861
A statistical thermodynamic model of the protein ensembleQ36472751
GPCR functional selectivity has therapeutic impactQ36880909
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.Q36880915
Pharmacological onomastics: what's in a name?Q36911200
Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptorsQ37199106
Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signallingQ37209196
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligandsQ37210835
Molecular determinants of angiotensin II type 1 receptor functional selectivityQ37291841
Physiological and pharmacological implications of beta-arrestin regulation.Q37356068
'7TM receptor allostery: putting numbers to shapeshifting proteinsQ37591623
Multiple mechanisms of serotonergic signal transductionQ38177519
Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.Q39749438
Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivityQ39884754
Multiplexed assays by high-content imaging for assessment of GPCR activityQ39976157
Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited modelQ40147596
Resonant waveguide grating biosensor for living cell sensing.Q40269125
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transferQ40281519
Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacyQ40298849
Molecular mechanisms of membrane receptor desensitization.Q40491298
Selective signaling via unique M1 muscarinic agonistsQ40779652
Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivoQ40948644
Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition.Q41842236
Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.Q42937057
Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytesQ44051395
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathwayQ44956223
Analysis of allosterism in functional assaysQ46171612
Morphine side effects in beta-arrestin 2 knockout miceQ46510708
New strategies in drug discovery for GPCRs: high throughput detection of cellular ERK phosphorylationQ46553254
Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor StimulusQ47866757
Agonist efficacy and allosteric models of receptor action.Q52264097
Conformational changes and drug actionQ70973331
Pharmacological basis for functional selectivity of partial muscarinic receptor agonistsQ71149990
Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2Q81391001
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbiasQ742736
P304page(s)296-302
P577publication date2010-10-28
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleFunctional selectivity and biased receptor signaling
Functional Selectivity and Biased Receptor Signaling
P478volume336

Reverse relations

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