Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

scientific article

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI25330
P932PMC publication ID1265872
P698PubMed publication ID16276415

P50authorStephen F VatnerQ96766914
Dorothy E VatnerQ106874985
Junichi SadoshimaQ51313947
Dan RodenQ58973971
P2093author name stringJing Liu
Xianzhong Yu
Peiyong Zhai
Sabina Kupershmidt
Thomas Wagner
Keiichi Irie
Atsuko Yatani
Jill Thaisz
Eric Holle
Jonathan Galeotti
Mitsutaka Yamamoto
Malthi Masurekar
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AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.Q43845849
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Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytesQ44477120
Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.Q44786855
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.Q44898088
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heartQ45004117
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytesQ45108317
Characterization of angiotensin II receptor subtypes in rat heartQ46376858
Oncogenic src, raf, and rasStimulate a Hypertrophic Pattern of Gene Expression and Increase Cell Size in Neonatal Rat Ventricular MyocytesQ47285549
Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits galphaq protein signaling but not ERK activationQ47843623
Versatility of the angiotensin II type 1 receptor.Q47904428
Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays.Q49164908
Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction systemQ52179820
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AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestrationQ24290268
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart blockQ24338156
Molecular tinkering of G protein-coupled receptors: an evolutionary successQ24534016
The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signalingQ24607635
RSK2 activity is regulated by its interaction with PEA-15Q28177939
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinaseQ28204643
Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitroQ28281048
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptorQ28301248
Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptorQ28565959
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophyQ28569255
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitroQ28570955
Heptahelical receptor signaling: beyond the G protein paradigm.Q33648620
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failureQ33853316
Protein-protein interactions at G-protein-coupled receptorsQ34093414
Cytoplasmic signaling pathways that regulate cardiac hypertrophyQ34142151
G-proteins in growth and apoptosis: lessons from the heartQ34226037
G-protein-coupled receptors and signaling networks: emerging paradigms.Q34296103
The angiotensin II type 1 receptor and receptor-associated proteinsQ34408092
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The renin-angiotensin system in the twenty-first centuryQ34513793
G-protein-coupled receptor oligomerization and its potential for drug discoveryQ34932201
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectbradycardiaQ217111
overexpressionQ61643320
P304page(s)3045-3056
P577publication date2005-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
P478volume115

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