review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Nabila Noor | |
Howard A. Rockman | |||
Chetan B. Patel | |||
P2860 | cites work | Functional Selectivity and Classical Concepts of Quantitative Pharmacology | Q22242288 |
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor | Q22253381 | ||
Functional specialization of beta-arrestin interactions revealed by proteomic analysis | Q24318455 | ||
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 | Q24532154 | ||
Transduction of receptor signals by beta-arrestins | Q28246395 | ||
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization | Q28276743 | ||
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor | Q28572837 | ||
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation | Q28577649 | ||
Regulation of carbamoyl phosphate synthetase by MAP kinase | Q28578262 | ||
beta-arrestin-biased agonism at the beta2-adrenergic receptor | Q40034384 | ||
Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET. | Q40110003 | ||
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer | Q40281519 | ||
Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy | Q40298849 | ||
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. | Q41080173 | ||
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases | Q41175767 | ||
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts | Q41714300 | ||
beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress | Q41917803 | ||
The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling | Q42441168 | ||
Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling | Q42453523 | ||
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. | Q42800979 | ||
Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling | Q42804681 | ||
Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor | Q43586918 | ||
Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure | Q44528608 | ||
β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure | Q44591642 | ||
PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching | Q45069283 | ||
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol | Q46048377 | ||
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies | Q46260678 | ||
Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan | Q46507308 | ||
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation | Q50335944 | ||
Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death. | Q51094115 | ||
The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts. | Q53021334 | ||
The Angiotensin II Type 1 Receptor Gene Polymorphism Is Associated With Coronary Artery Vasoconstriction | Q57606076 | ||
Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet | Q74316955 | ||
Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome | Q81272805 | ||
Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury | Q82828304 | ||
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy | Q29615215 | ||
Beta-arrestins and cell signaling | Q29616793 | ||
Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. | Q30476292 | ||
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol | Q30478644 | ||
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes | Q33181618 | ||
Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity | Q33714695 | ||
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling | Q33819399 | ||
beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation | Q33840022 | ||
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery | Q33890786 | ||
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group | Q33893139 | ||
Inverse, protean, and ligand-selective agonism: matters of receptor conformation | Q33938998 | ||
Teaching old receptors new tricks: biasing seven-transmembrane receptors | Q33985759 | ||
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). | Q34093722 | ||
Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists | Q34122067 | ||
Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study | Q34155432 | ||
Principles: receptor theory in pharmacology | Q34310931 | ||
Seven-transmembrane-spanning receptors and heart function | Q34503394 | ||
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol | Q34522261 | ||
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. | Q34536660 | ||
Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor | Q34548751 | ||
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor | Q34562493 | ||
Integrating signals from RTKs to ERK/MAPK. | Q34627656 | ||
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes | Q35133773 | ||
Ligand-selective receptor conformations revisited: the promise and the problem | Q35181787 | ||
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. | Q35951476 | ||
A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling | Q36082162 | ||
New concepts in drug discovery: collateral efficacy and permissive antagonism | Q36303814 | ||
Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. | Q36786816 | ||
The evasive nature of drug efficacy: implications for drug discovery | Q36894549 | ||
Mitogenic signaling pathways induced by G protein-coupled receptors | Q36929839 | ||
Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. | Q36936400 | ||
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure | Q37000342 | ||
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. | Q37105461 | ||
'7TM receptor allostery: putting numbers to shapeshifting proteins | Q37591623 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | membrane protein | Q423042 |
hormone | Q11364 | ||
peptide | Q172847 | ||
angiotensin receptor | Q2504907 | ||
nerve tissue protein | Q6996861 | ||
signal transduction | Q828130 | ||
cell surface receptor | Q2476074 | ||
P304 | page(s) | 983-992 | |
P577 | publication date | 2010-09-20 | |
2010-12-01 | |||
P1433 | published in | Molecular Pharmacology | Q1943386 |
P1476 | title | Functional selectivity in adrenergic and angiotensin signaling systems | |
Functional Selectivity in Adrenergic and Angiotensin Signaling Systems | |||
P478 | volume | 78 |