Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine

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Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1025627221
P356DOI10.1038/SJ.NPP.1301414
P698PubMed publication ID17429406
P5875ResearchGate publication ID6399868

P2093author name stringKathryn A Cunningham
Umberto Spampinato
Sylvia Navailles
Delphine Moison
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GABA(A) receptor blockade in the anterior ventral tegmental area increases extracellular levels of dopamine in the nucleus accumbens of ratsQ48677414
Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brainQ48819954
In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each otherQ48896592
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Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission.Q51420643
Cocaine inhibits GABA release in the VTA through endogenous 5-HT.Q51620589
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Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbensQ33667218
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5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum.Q34114593
Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaineQ34117803
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Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortexQ34193683
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Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.Q34310093
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5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulantsQ34373436
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonistQ34432766
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Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment.Q42472207
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Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptorsQ42488122
m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptorsQ42503089
Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brainQ42505808
Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA.Q42511751
Stimulation of 5-hydroxytryptamine (5-HT(2C) ) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortexQ42523067
Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbensQ43658239
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Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.Q44213533
Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbensQ44326778
Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administrationQ44686785
m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptorQ44773825
Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studiesQ44849193
Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivoQ46718990
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P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
nucleus accumbensQ1476178
P304page(s)237-246
P577publication date2007-04-11
P1433published inNeuropsychopharmacologyQ2261280
P1476titleDifferential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine
P478volume33

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