Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

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Nucleus accumbens shell and core dopamine: differential role in behavior and addiction is …
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review articleQ7318358
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P356DOI10.1016/S0166-4328(02)00286-3
P698PubMed publication ID12445717

P2093author name stringGaetano Di Chiara
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Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats.Q51759517
Coincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning.Q52164485
Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.Q52167048
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Dopamine receptor antagonists attenuate conditioned place preference following sexual behavior in female Syrian hamsters.Q52200406
Habit-forming actions of nomifensine in nucleus accumbens.Q52204812
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Effects of ibotenic acid lesions of the nucleus accumbens on instrumental action.Q52212359
Nicotine place preference using the biased method of conditioning.Q52214660
Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food.Q52215423
Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat.Q52221152
Behavior-associated changes in blood pressure during heroin self-administration.Q52221923
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress.Q52238692
Pimozide prevents the response-reinstating effects of water reinforcement in rats.Q52239772
A matching law analysis of the effects of dopamine receptor antagonists.Q52243318
The use of place conditioning in studying the neuropharmacology of drug reinforcement.Q52244857
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processesQ37921802
Dopamine, neuroleptics and reinforced behaviorQ38366634
Opponent process theory of motivation: neurobiological evidence from studies of opiate dependenceQ38715681
Limbic-striatal interactions in reward-related processesQ38715695
Dissociating the effects of altered dopaminergic function on performance and learningQ38730027
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The role of dopamine in drug abuse viewed from the perspective of its role in motivationQ40480641
The involvement of nucleus accumbens dopamine in appetitive and aversive motivation.Q40675441
Brain microdialysis and its application for the study of animal behaviourQ40945394
Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neuronsQ41048190
Discriminated escape learning and response to electric shock after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projectionQ41066884
Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugsQ41068587
Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug developmentQ41280514
Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioningQ41339342
Haloperidol blocks the response-reinstating effects of food reward: a methodology for separating neuroleptic effects on reinforcement and motor processesQ41420759
Mnemonic functions of the basal ganglia.Q41463747
Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesisQ41485902
Opponent Process Model and Psychostimulant AddictionQ41527831
Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systemsQ41555259
Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in ratsQ41573401
Haloperidol does not attenuate conditioned place preferences or locomotor activation produced by food- or heroin-predictive discriminative cuesQ41646776
Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in ratsQ41652499
The interaction of cognitive and stimulus-response processes in the control of behaviourQ41716302
Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysisQ42009302
Haloperidol blocks the conditioned place preferences induced by rewarding brain stimulationQ42129266
Neurobiology of withdrawal motivation: evidence for two separate aversive effects produced in morphine-naive versus morphine-dependent rats by both naloxone and spontaneous withdrawalQ42278906
Depression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinenceQ42450949
Conditioned dopamine release: dependence upon N-methyl-D-aspartate receptorsQ42474385
Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinenceQ42524725
Potentiation by low doses of selected neuroleptics of food-induced conditioned place preference in rats.Q42690622
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issuesQ43070521
Effects of haloperidol in a response-reinstatement model of heroin relapseQ43432977
Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis studyQ43450848
Haloperidol prevents the reinstatement of amphetamine-rewarded runway responding in ratsQ43531105
The role of the nucleus accumbens in instrumental conditioning: Evidence of a functional dissociation between accumbens core and shell.Q43581732
Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene.Q43581741
Dopamine antagonism attenuates the unconditioned incentive value of estrous female cuesQ43590193
Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission.Q43697277
Sub-second changes in accumbal dopamine during sexual behavior in male ratsQ43701868
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumptionQ43709781
A role for dopamine D1 receptors of the nucleus accumbens shell in conditioned taste aversion learning.Q43715968
Incentive sensitization by previous amphetamine exposure: increased cue-triggered "wanting" for sucrose reward.Q43744887
Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior.Q43805383
Selective responding of nucleus accumbens core and shell dopamine to aversively conditioned contextual and discrete stimuliQ43818706
Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex.Q44012270
Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats.Q44047413
Cocaine-induced conditioned locomotion: Absence of associated increases in dopamine releaseQ44228654
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
nucleus accumbensQ1476178
P304page(s)75-114
P577publication date2002-12-01
P1433published inBehavioural Brain ResearchQ3619047
P1476titleNucleus accumbens shell and core dopamine: differential role in behavior and addiction
P478volume137

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Q40331420Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex
Q34637093Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum.
Q37458263Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction.
Q44706599Clozapine and dopamine D3 receptor antisense reduce cocaine- and amphetamine-regulated transcript expression in the rat nucleus accumbens shell
Q48178347Cocaine sensitization models an anhedonia-like condition in rats
Q44824836Cocaine's long run.
Q37789757Cocaine, metamfetamine, and MDMA abuse: the role and clinical importance of neuroadaptation
Q38040253Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.
Q37554546Cocaine-induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice
Q44348883Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum.
Q90580196Cognitive dysfunction in individuals with cocaine use disorder: Potential moderating factors and pharmacological treatments
Q90649769Comparison of the Time-Dependent Changes in Immediate Early Gene Labeling and Spine Density Following Abstinence From Contingent or Non-contingent Chocolate Pellet Delivery
Q36293008Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement.
Q37883081Computational models of reinforcement learning: the role of dopamine as a reward signal
Q28290902Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2
Q35063979Conditioned Aversion for a Cocaine-Predictive Cue is Associated with Cocaine Seeking and Taking in Rats
Q26851391Considering the definition of addiction
Q34310093Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.
Q42519971Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens
Q39147170Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors
Q48032192Decrease of GSK3β phosphorylation in the rat nucleus accumbens core enhances cocaine-induced hyper-locomotor activity
Q26800541Deep Brain Stimulation for Obesity
Q47571269Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
Q34157737Delays conferred by escalating costs modulate dopamine release to rewards but not their predictors
Q36615988Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference
Q35746857Descending projections from the nucleus accumbens shell excite activity of taste-responsive neurons in the nucleus of the solitary tract in the hamster
Q48474211Descending projections from the nucleus accumbens shell suppress activity of taste-responsive neurons in the hamster parabrachial nuclei
Q37606920Development and function of the midbrain dopamine system: what we know and what we need to
Q47886243Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D2-like receptor tone in the nucleus accumbens
Q44540581Differential changes in signal and background firing of accumbal neurons during cocaine self-administration
Q45248986Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice
Q33771055Differential effects of dopamine and opioid receptor blockade on motivated Coca-Cola drinking behavior and associated changes in brain, skin and muscle temperatures
Q47372562Differential effects of the MEK inhibitor SL327 on the acquisition and expression of ethanol-elicited conditioned place preference and aversion in mice
Q48384122Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex
Q30492722Differential involvement of dopamine receptors in conditioned suppression induced by cocaine
Q48437280Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat.
Q46736600Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs
Q34618432Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine
Q34162671Differential-reinforcement-of-low-rate-schedule performance and nicotine administration: a systematic investigation of dose, dose-regimen, and schedule requirement
Q35098064Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems
Q36913451Divergent effects of D₂/₃ receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats
Q35945280Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity
Q34984707Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice.
Q44574122Dopamine efflux in nucleus accumbens shell and core in response to appetitive classical conditioning
Q22251253Dopamine in motivational control: rewarding, aversive, and alerting
Q37601486Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling
Q44615585Dopamine responsiveness to drugs of abuse: A shell‐core investigation in the nucleus accumbens of the mouse
Q24681363Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.
Q37344627Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine
Q37821386Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Q34538406Dopamine transporter inhibition is necessary for cocaine‐induced increases in dendritic spine density in the nucleus accumbens
Q29616245Dopamine, learning and motivation
Q33593384Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson's disease: insights from functional imaging
Q35697823Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons
Q28084459Dopaminergic and cholinergic learning mechanisms in nicotine addiction
Q46503093Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Q35954309Drug addiction: the neurobiology of behaviour gone awry
Q48186120Effect of Ginkgo biloba extract on lipopolysaccharide-induced anhedonic depressive-like behavior in male rats
Q28574029Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas
Q92257946Effects of Ethanol Exposure and Withdrawal on Neuronal Morphology in the Agranular Insular and Prelimbic Cortices: Relationship with Withdrawal-Related Structural Plasticity in the Nucleus Accumbens
Q93257551Effects of cannabis exposure in the prenatal and adolescent periods: preclinical and clinical studies in both sexes
Q34711395Effects of ethanol exposure and withdrawal on dendritic morphology and spine density in the nucleus accumbens core and shell.
Q59809322Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats
Q42282272Effects of novelty and methamphetamine on conditioned and sensory reinforcement
Q37274955Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing
Q34602346Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
Q34417283Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns
Q36881952Emerging role for corticotropin releasing factor signaling in the bed nucleus of the stria terminalis at the intersection of stress and reward
Q34359778Endocannabinoid 2-Arachidonoylglycerol Self-Administration by Sprague-Dawley Rats and Stimulation of in vivo Dopamine Transmission in the Nucleus Accumbens Shell.
Q36469706Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice
Q38123803Ethanol-derived acetaldehyde: pleasure and pain of alcohol mechanism of action
Q27313191Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
Q36944835Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain.
Q36665853Exploratory studies in sensory reinforcement in male rats: effects of methamphetamine
Q43092673Exposure to Kynurenic Acid during Adolescence Increases Sign-Tracking and Impairs Long-Term Potentiation in Adulthood
Q36274171Exposure to nicotine and sensitization of nicotine-induced behaviors
Q55300833Expression and localization of CB1R, NAPE-PLD, and FAAH in the vervet monkey nucleus accumbens.
Q42069029Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex
Q37146969Extracellular signal-related kinase activation during natural reward learning: a physiological role for phasic nucleus accumbens dopamine?
Q44658287Facilitation of conditioned taste aversion learning by systemic amphetamine: role of nucleus accumbens shell dopamine D1 receptors
Q38604165Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature
Q26768236Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction
Q27348463Fluctuations in nucleus accumbens extracellular glutamate and glucose during motivated glucose-drinking behavior: dissecting the neurochemistry of reward
Q48117503Food addiction and obesity: evidence from bench to bedside
Q28067932Food addiction as a new piece of the obesity framework
Q48387145Food reward-induced neurotransmitter changes in cognitive brain regions
Q30354013Framework for sex differences in adolescent neurobiology: a focus on cannabinoids.
Q38786126Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption
Q37781424GSK-3β activity and hyperdopamine-dependent behaviors
Q37836741Galanin and consummatory behavior: special relationship with dietary fat, alcohol and circulating lipids.
Q40396620Gene expression differences in mice divergently selected for methamphetamine sensitivity
Q28731615Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors
Q35784539Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism
Q42871144Getting good or getting well?
Q52147495Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens.
Q36029486Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression
Q28112161Glutamatergic transmission in drug reward: implications for drug addiction
Q45226996Glycine receptors regulate dopamine release in the rat nucleus accumbens
Q52298572Glycogen synthase kinase 3β in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization.
Q47163409Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia.
Q44619614Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards.
Q35639591Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons
Q37455421Hypothalamic injection of non-opioid peptides increases gene expression of the opioid enkephalin in hypothalamic and mesolimbic nuclei: Possible mechanism underlying their behavioral effects
Q30413183Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior
Q33887107Identifying the neural circuitry of alcohol craving and relapse vulnerability
Q38066730Imaging impulse control disorders in Parkinson's disease and their relationship to addiction
Q38408407Immediate early gene expression reveals interactions between social and nicotine rewards on brain activity in adolescent male rats.
Q37615116Impact of appetitive and aversive outcomes on brain responses: linking the animal and human literatures.
Q48505892Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists
Q45067538In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens
Q50980424Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward.
Q43247802Individual differences in dopamine efflux in nucleus accumbens shell and core during instrumental learning
Q28087262Individual differences in the behavioral effects of nicotine: A review of the preclinical animal literature
Q36017250Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.
Q47629871Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central metabolic and peripheral vascular responses.
Q44521810Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuli
Q36978463Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats
Q39853169Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice
Q36250084Inhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation
Q48717775Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission.
Q39676986Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats
Q38222863Internet and gaming addiction: a systematic literature review of neuroimaging studies
Q34386393Internet gaming addiction: current perspectives
Q44682593Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats
Q33771081Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response
Q40033873Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement
Q48421452Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control.
Q35645209Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain.
Q46647218Kindling modifies morphine, cocaine and ethanol place preference
Q42248085Knockdown of tropomyosin-related kinase B receptor expression in the nucleus accumbens shell prevents intermittent social defeat stress-induced cross-sensitization to amphetamine in rats.
Q34277629Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Q48113066Levodopa treatment and dendritic spine pathology
Q42568290Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway
Q36812804MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro
Q39345691MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment
Q37663154MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity
Q48863959Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids.
Q55505653Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship.
Q33597559Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression
Q37791061Methylxanthines and Drug Dependence: A Focus on Interactions with Substances of Abuse
Q46829200Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward
Q48209471MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens.
Q37103322Midbrain-driven emotion and reward processing in alcoholism
Q59800039Mindfulness meditation in the treatment of substance use disorders and preventing future relapse: neurocognitive mechanisms and clinical implications
Q38004825Modularity of mind and the role of incentive motivation in representing novelty
Q27014154Modulation of the endocannabinoid system: vulnerability factor and new treatment target for stimulant addiction
Q47284247Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior
Q33890933Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux
Q48522630Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression
Q57170466Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity
Q35023233Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell
Q48451260Neuroadaptations of Cdk5 in cholinergic interneurons of the nucleus accumbens and prefrontal cortex of inbred alcohol-preferring rats following voluntary alcohol drinking
Q26774129Neurobiologic Advances from the Brain Disease Model of Addiction
Q56992675Neurobiology of Alcohol Craving and Relapse Prediction
Q34000048Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety
Q36849881Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).
Q33998601Neurology of action and motivation: impulsive humor and hyperactivity
Q36137598Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions
Q38796120Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache
Q36376434Neuropharmacology and potential efficacy of new treatments for tobacco dependence
Q38567125Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.
Q89713011Neurotensin in reward processes
Q42467626Neurotensin: revealing a novel neuromodulator circuit in the nucleus accumbens-parabrachial nucleus projection of the domestic chick
Q35250937New perspectives on adolescent motivated behavior: attention and conditioning
Q39061327Nicotine produces chronic behavioral sensitization with changes in accumbal neurotransmission and increased sensitivity to re-exposure.
Q46845801Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition
Q37525085Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction
Q34631254Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse
Q30455336Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Q26853630Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation
Q22242289Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse
Q48394211Nucleus accumbens PKA inhibition blocks acquisition but enhances expression of amphetamine-produced conditioned activity in rats
Q46835495Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds
Q48347614Nucleus accumbens shell and core dopamine responsiveness to sucrose in rats: role of response contingency and discriminative/conditioned cues
Q27305182Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism
Q39254238Obesity and addiction: can a complication of surgery help us understand the connection?
Q93085010Off-Target Effects in Transgenic Mice: Characterization of Dopamine Transporter (DAT)-Cre Transgenic Mouse Lines Exposes Multiple Non-Dopaminergic Neuronal Clusters Available for Selective Targeting within Limbic Neurocircuitry
Q47301293On Mourning and Recovery: Integrating Stages of Grief and Change Toward a Neuroscience-Based Model of Attachment Adaptation in Addiction Treatment.
Q47952432Once is too much: Early development of the opponent process in taste reactivity behavior is associated with later escalation of cocaine self-administration in rats.
Q34846394Opioids and the treatment of chronic pain: controversies, current status, and future directions
Q36619467Opioids for hedonic experience and dopamine to get ready for it.
Q42108841Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake
Q33666303Opioids in the hypothalamus control dopamine and acetylcholine levels in the nucleus accumbens
Q24678376Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides
Q48455589Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine-seeking behaviour in rats.
Q35006177Parsing glucose entry into the brain: novel findings obtained with enzyme-based glucose biosensors.
Q35209228Parsing reward
Q44548755Persistent cue-evoked activity of accumbens neurons after prolonged abstinence from self-administered cocaine.
Q48616882Persistent disruption of an established morphine conditioned place preference.
Q33245150Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats
Q39191804Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences
Q36867079Pre-existing differences and diet-induced alterations in striatal dopamine systems of obesity-prone rats
Q42488958Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration
Q36709288Prenatal ethanol exposure stimulates neurogenesis in hypothalamic and limbic peptide systems: possible mechanism for offspring ethanol overconsumption
Q35179006Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats
Q46886459Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.
Q34400233Protection genes in nucleus accumbens shell affect vulnerability to nicotine self-administration across isogenic strains of adolescent rat
Q49013090Psychostimulant treatment of combat-related posttraumatic stress disorder
Q37362242Putative role of brain acetaldehyde in ethanol addiction
Q33839782Quantitative analysis of pre- and postsynaptic sex differences in the nucleus accumbens.
Q28478907Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats
Q45153783Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration
Q38805493Recent studies of the effects of sugars on brain systems involved in energy balance and reward: Relevance to low calorie sweeteners
Q51894846Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drug-conditioned stimuli
Q42599097Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition.
Q52686702Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.
Q47435750Region-specific effects of developmental exposure to cocaine on fibroblast growth factor-2 expression in the rat brain.
Q35046370Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist
Q30495511Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core
Q36908950Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala
Q30441129Repeated intravenous amphetamine exposure: rapid and persistent sensitization of 50-kHz ultrasonic trill calls in rats
Q49357184Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats
Q37322830Reward and punishment sensitivity in shy and non-shy adults: Relations between social and motivated behavior
Q37384906Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers
Q28068951Role of Nitric Oxide on Dopamine Release and Morphine-Dependency
Q35792661Role of acetylcholine transmission in nucleus accumbens and ventral tegmental area in heroin-seeking induced by conditioned cues
Q35907433Role of nucleus accumbens in neuropathic pain: linked multi-scale evidence in the rat transitioning to neuropathic pain
Q35120472Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity
Q48126418Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses
Q37103059Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
Q44342984Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats
Q44658214Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine.
Q46294516Self-administration of the GABAA agonist muscimol into the medial septum: dependence on dopaminergic mechanisms.
Q34749714Separate populations of neurons in ventral striatum encode value and motivation
Q33791677Separating analgesia from reward within the ventral tegmental area
Q24596784Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens
Q47894329Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine
Q47287052Sex-specific effects of developmental alcohol exposure on cocaine-induced place preference in adulthood
Q37346653Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats.
Q35044527Social anxiety, acute social stress, and reward parameters interact to predict risky decision-making among adolescents
Q30364679Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum
Q48217027Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration.
Q40228670Stereotactic neurosurgical technique and electrophysiological study in ablating the ventromedial shell of the nucleus accumbens
Q30435564Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer
Q103804472Stress and the dopaminergic reward system
Q28266784Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens
Q59134991Sugar Addiction: From Evolution to Revolution
Q37400974Sustained striatal activity predicts eudaimonic well-being and cortisol output.
Q36713932Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
Q37702356Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse
Q60047660Systemic Administration of Orexin a Loaded Liposomes Potentiates Nucleus Accumbens Shell Dopamine Release by Sucrose Feeding
Q46605162Systemic and intra-accumbens microinjections of naltrexone interfere with tolerance to ethanol in rats
Q36786609Systems level neuroplasticity in drug addiction
Q35877428Tamping Ramping: Algorithmic, Implementational, and Computational Explanations of Phasic Dopamine Signals in the Accumbens
Q37079817Temporal Specificity of Reward Prediction Errors Signaled by Putative Dopamine Neurons in Rat VTA Depends on Ventral Striatum
Q26798096The Brain on Drugs: From Reward to Addiction
Q51020233The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study.
Q24802073The Molecular Pages of the mesotelencephalic dopamine consortium (DopaNet)
Q30794301The addicted human brain: insights from imaging studies
Q36176513The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats
Q21129358The central GLP-1: implications for food and drug reward
Q34317475The contribution of brain reward circuits to the obesity epidemic
Q29618738The debate over dopamine's role in reward: the case for incentive salience
Q46727182The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in rats
Q36083476The dopamine hypothesis of drug addiction: hypodopaminergic state.
Q34448593The dopamine response in the nucleus accumbens core-shell border differs from that in the core and shell during operant ethanol self-administration
Q33905665The emergence of gonadal hormone influences on dopaminergic function during puberty
Q36630516The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing
Q37888955The endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications.
Q34333767The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?
Q46670474The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine.
Q37167735The melanin-concentrating hormone system modulates cocaine reward
Q45247886The mesolimbic dopaminergic response to novel palatable food consumption increases dopamine-D1 receptor-mediated signalling with complex modifications of the DARPP-32 phosphorylation pattern.
Q30957200The neural circuitry of reward and its relevance to psychiatric disorders
Q38385053The neural correlates of priming emotion and reward systems for conflict processing in alcoholics
Q29618579The neurobiology of pair bonding
Q38933609The neurocircuitry involved in oxytocin modulation of methamphetamine addiction.
Q36741890The neurocircuitry of addiction: an overview
Q22242634The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
Q35089044The nucleus accumbens and Pavlovian reward learning
Q36597398The nucleus accumbens as part of a basal ganglia action selection circuit
Q46464300The nucleus accumbens core has a more important role in resisting reactivation of extinguished conditioned place preference in morphine-addicted rats
Q37142233The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction.
Q90576672The reality of "food porn": Larger brain responses to food-related cues than to erotic images predict cue-induced eating
Q33214750The role of dopamine in reward and pleasure behaviour--review of data from preclinical research
Q38338790The role of mesoaccumbens dopamine in nicotine dependence
Q34429137The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal
Q37284230The role of the striatum in aversive learning and aversive prediction errors
Q46406729The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards
Q34032576The tempted brain eats: pleasure and desire circuits in obesity and eating disorders
Q37046585The ventral striatum as an interface between the limbic and motor systems
Q52302992Three dimensional anatomy of the human nucleus accumbens.
Q36848916Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens
Q46092730Translating genetics, cognitive science, and other basic science research findings into applications for prevention
Q36393926Triadic model of the neurobiology of motivated behavior in adolescence
Q38990044Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder
Q48058857Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence.
Q48608961Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats
Q38992288Using model systems to understand errant plasticity mechanisms in psychiatric disorders
Q35647946Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3β Signaling in the Nucleus Accumbens Core
Q46986749Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.
Q41915338Ventral striatal neurons encode the value of the chosen action in rats deciding between differently delayed or sized rewards
Q39653976Ventral striatum encodes past and predicted value independent of motor contingencies
Q33591477Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization
Q37182956Voluntary alcohol drinking enhances proopiomelanocortin gene expression in nucleus accumbens shell and hypothalamus of Sardinian alcohol-preferring rats
Q35423539Voluntary ethanol intake predicts κ-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques
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