| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/AJMG.A.20477 |
| P953 | full work available at URL | https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.a.20477 |
| https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.a.20477 | ||
| P698 | PubMed publication ID | 14518069 |
| P50 | author | Charis Eng | Q37385393 |
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Germline mutation of the tumour suppressor PTEN in Proteus syndrome | Q24672675 | ||
| Will the real Cowden syndrome please stand up: revised diagnostic criteria | Q24681567 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| A serine/threonine kinase gene defective in Peutz-Jeghers syndrome | Q28119198 | ||
| PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model | Q28202775 | ||
| Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase | Q28258611 | ||
| Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis | Q28300857 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Male breast cancer in Cowden syndrome patients with germline PTEN mutations | Q28359884 | ||
| Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers | Q28393163 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
| The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway | Q28611339 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome | Q29615538 | ||
| The Cowden syndrome: a clinical and genetic study in 21 patients | Q69486172 | ||
| Hydrocephalus with features of VATER | Q72343143 | ||
| Identification of a PTEN mutation in a family with Cowden syndrome and Bannayan-Zonana syndrome | Q73431855 | ||
| Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease | Q73672434 | ||
| Expression of the PTEN tumour suppressor protein during human development | Q73911026 | ||
| PTEN germ-line mutations in juvenile polyposis coli | Q74026971 | ||
| Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN | Q77342895 | ||
| Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations | Q77421649 | ||
| The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene | Q77726383 | ||
| Cowden Syndrome | Q85527281 | ||
| PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways | Q31837554 | ||
| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway | Q33599964 | ||
| Proteus syndrome: diagnostic criteria, differential diagnosis, and patient evaluation | Q33653132 | ||
| Cowden syndrome | Q33675760 | ||
| Germline PTEN mutations in Cowden syndrome-like families. | Q33681468 | ||
| PTEN expression causes feedback upregulation of insulin receptor substrate 2 | Q33968441 | ||
| Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes | Q34020502 | ||
| A gene for familial juvenile polyposis maps to chromosome 18q21.1. | Q34385458 | ||
| PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome | Q34504165 | ||
| VATER and hydrocephalus: distinct syndrome? | Q34616392 | ||
| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. | Q34742581 | ||
| Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene | Q35063217 | ||
| The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. | Q35250021 | ||
| Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis | Q35250337 | ||
| A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association | Q35436505 | ||
| Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1. | Q35436601 | ||
| The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway | Q36396479 | ||
| The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila | Q39120031 | ||
| Cowden syndrome (multiple hamartoma syndrome). | Q40504443 | ||
| Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis | Q40770781 | ||
| The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis | Q40920116 | ||
| Phosphoinositide 3-kinase and the regulation of cell growth | Q41078881 | ||
| Cowden disease. Report of a family and review | Q41593956 | ||
| Molecular classification of the inherited hamartoma polyposis syndromes: clearing the muddied waters | Q41872534 | ||
| PTEN mutations are uncommon in Proteus syndrome. | Q43045274 | ||
| Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene | Q43218218 | ||
| Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation | Q45345194 | ||
| Mutations in the SMAD4/DPC4 gene in juvenile polyposis | Q45345229 | ||
| Genetic heterogeneity in familial juvenile polyposis | Q46098220 | ||
| Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways | Q47070325 | ||
| Germline mutations in PTEN are present in Bannayan-Zonana syndrome | Q48046915 | ||
| Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome. | Q51996177 | ||
| Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. | Q52176250 | ||
| Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes | Q57591248 | ||
| To be or not to BMP | Q57591257 | ||
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies | Q57591287 | ||
| Localization of the gene for Cowden disease to chromosome 10q22–23 | Q57694734 | ||
| High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
| Bannayan-Riley-Ruvalcaba syndrome | Q67509446 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | genetics | Q7162 |
| constipation | Q178436 | ||
| P304 | page(s) | 315-322 | |
| P577 | publication date | 2003-11-01 | |
| P1433 | published in | American Journal of Medical Genetics | Q4744254 |
| P1476 | title | Constipation, polyps, or cancer? Let PTEN predict your future | |
| Constipation, polyps, or cancer? let PTEN predict your future | |||
| P478 | volume | 122A |
| Q34579796 | Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers |
| Q51809966 | Cowden syndrome: a major indication for extensive cancer surveillance. |
| Q34380413 | Dysregulation of the TSC-mTOR pathway in human disease |
| Q33722586 | Germline PTEN mutations are rare and highly penetrant |
| Q83767560 | Hamartomatous polyposis syndromes |
| Q37181471 | Muscle hemangiomatosis presenting as a severe feature in a patient with the pten mutation: expanding the phenotype of vascular malformations in bannayan-riley-ruvalcaba syndrome |
| Q39185396 | Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma |
| Q35447328 | The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis |
| Q35889659 | Variants on the promoter region of PTEN affect breast cancer progression and patient survival |
| Q82353332 | [Perianal verrucous papules in a patient with Bannayan-Riley-Ruvalcaba syndrome] |
| Q36919646 | mTOR signalling in human cancer |
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