| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.C100160200 |
| P698 | PubMed publication ID | 11546755 |
| P2093 | author name string | Kadowaki T | |
| Nagai R | |||
| Kubota N | |||
| Abe M | |||
| Suzuki R | |||
| Kimura S | |||
| Aoyama M | |||
| Tanaka J | |||
| Yamauchi T | |||
| Akanuma Y | |||
| Tobe K | |||
| Terauchi Y | |||
| Ohsumi J | |||
| Matsui J | |||
| Kamon J | |||
| P2860 | cites work | Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 |
| A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family | Q24323752 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells | Q24561820 | ||
| Expression monitoring by hybridization to high-density oligonucleotide arrays | Q27860473 | ||
| Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice | Q28144106 | ||
| The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor | Q28238069 | ||
| The IRS-signalling system: a network of docking proteins that mediate insulin action | Q28272481 | ||
| Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets | Q28344493 | ||
| Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease | Q28510789 | ||
| ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose | Q28583495 | ||
| Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes | Q28646399 | ||
| PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance | Q29622888 | ||
| Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance | Q33588931 | ||
| Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes | Q33878155 | ||
| Insights into insulin resistance and type 2 diabetes from knockout mouse models | Q34011039 | ||
| Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors | Q34263181 | ||
| Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes | Q36698641 | ||
| Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a | Q37360326 | ||
| Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells | Q37364195 | ||
| Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus | Q38319698 | ||
| Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice | Q40019067 | ||
| Adipogenesis and obesity: rounding out the big picture | Q41193513 | ||
| ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism | Q42813608 | ||
| Role of brain insulin receptor in control of body weight and reproduction | Q47229086 | ||
| The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family | Q48050897 | ||
| Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. | Q48702756 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. | Q52512624 | ||
| Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. | Q52535322 | ||
| Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. | Q52541535 | ||
| Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. | Q54107503 | ||
| Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. | Q54177573 | ||
| Acute stimulation of glucose metabolism in mice by leptin treatment | Q59079790 | ||
| Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells | Q59079799 | ||
| IRS-2 pathways integrate female reproduction and energy homeostasis | Q59088199 | ||
| P433 | issue | 42 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P1104 | number of pages | 4 | |
| P304 | page(s) | 38337-38340 | |
| P577 | publication date | 2001-08-23 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver | |
| P478 | volume | 276 |
| Q33785270 | Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c |
| Q44804017 | Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice |
| Q24598294 | Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs |
| Q53447250 | Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. |
| Q38320096 | Comparison of expression of glucokinase gene and activities of enzymes related to glucose metabolism in livers between dog and cat. |
| Q33830715 | Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism |
| Q35598104 | Cytokines and the pathogenesis of non-alcoholic steatohepatitis |
| Q42478561 | Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency |
| Q37874856 | Does physical inactivity cause nonalcoholic fatty liver disease? |
| Q38334129 | Expression of DGAT2 in white adipose tissue is regulated by central leptin action |
| Q81621950 | Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice |
| Q84008571 | Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? |
| Q42965854 | Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice |
| Q33789340 | Inhibition of SREBP transcriptional activity by a boron-containing compound improves lipid homeostasis in diet-induced obesity |
| Q40753400 | Insig: a significant integrator of nutrient and hormonal signals |
| Q37532741 | Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus |
| Q36324480 | Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts |
| Q54631286 | Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907. |
| Q44316536 | Intima media thickness of carotid arteries is reduced in heterozygous carriers of the Gly972Arg variant in the insulin receptor substrate-1 gene |
| Q46984008 | Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model |
| Q37105304 | Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress |
| Q41850658 | MicroRNAs in metabolism and metabolic diseases |
| Q33612997 | MicroRNAs in metabolism and metabolic disorders |
| Q36013207 | Microarrays, antiobesity and the liver |
| Q36343495 | New insight into the pathophysiology of lipid abnormalities in type 2 diabetes |
| Q34682304 | New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c |
| Q36775874 | Nutrigenomics, beta-cell function and type 2 diabetes |
| Q35373126 | Nutritional recovery with a soybean diet after weaning reduces lipogenesis but induces inflammation in the liver in adult rats exposed to protein restriction during intrauterine life and lactation. |
| Q44912996 | Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides |
| Q33997240 | Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance |
| Q28582308 | PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity |
| Q38354027 | PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat. |
| Q36702291 | Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. |
| Q37736477 | Physiological insights gained from gene expression analysis in obesity and diabetes |
| Q64102156 | Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence |
| Q35839265 | Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat |
| Q35200197 | Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress |
| Q28570423 | Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression |
| Q36886903 | Regulation of SREBP-Mediated Gene Expression |
| Q51353132 | Regulation of hepatic insulin sensitivity by activating signal co-integrator-2. |
| Q42247586 | Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription |
| Q36020648 | Role of the liver in the control of carbohydrate and lipid homeostasis |
| Q36728656 | SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling |
| Q47868873 | SREBPs suppress IRS-2-mediated insulin signalling in the liver |
| Q35025259 | Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism |
| Q37431796 | Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity |
| Q30475796 | The role of insulin receptor substrate 2 in hypothalamic and beta cell function. |
| Q44324677 | The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction |
| Q47600568 | Thoracic gamma irradiation-induced obesity in C57BL/6 female mice |
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