| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1172/JCI10830 |
| P8608 | Fatcat ID | release_lus6y7vaq5gdvmhvtj756oyhwm |
| P932 | PMC publication ID | 380257 |
| P698 | PubMed publication ID | 10953020 |
| P2093 | author name string | T Kadowaki | |
| P2860 | cites work | Decreased Insulin Secretion and Increased Insulin Resistance Are Independently Related to the 7-Year Risk of NIDDM in Mexican-Americans | Q51584502 |
| Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients. | Q51617046 | ||
| Risk factors for worsening to diabetes in subjects with impaired glucose tolerance | Q51644565 | ||
| Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. | Q52174749 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. | Q52512624 | ||
| Prevention of insulin resistance and diabetes in mice heterozygous for GLUT4 ablation by transgenic complementation of GLUT4 in skeletal muscle. | Q52534465 | ||
| Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. | Q52535322 | ||
| Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. | Q52540333 | ||
| Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. | Q52541535 | ||
| Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. | Q54104864 | ||
| Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. | Q54177573 | ||
| Conditional gene targeting | Q57198351 | ||
| Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans | Q57308002 | ||
| Early neonatal death in mice homozygous for a null allele of the insulin receptor gene | Q60060440 | ||
| Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study | Q67521964 | ||
| Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles | Q73085036 | ||
| Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes | Q73770535 | ||
| Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction | Q74191142 | ||
| Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis | Q74303209 | ||
| A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance | Q77652485 | ||
| Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro | Q28146187 | ||
| GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes | Q28251696 | ||
| 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice | Q28289491 | ||
| Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats | Q28379378 | ||
| Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 | Q28507095 | ||
| Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose | Q28507345 | ||
| Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease | Q28510789 | ||
| Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase | Q28589116 | ||
| PPAR gamma is required for placental, cardiac, and adipose tissue development | Q29619912 | ||
| PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance | Q29622888 | ||
| PPARgamma, the ultimate thrifty gene | Q33711175 | ||
| The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes | Q33899154 | ||
| Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice | Q33901993 | ||
| Interactions between insulin resistance and insulin secretion in the development of glucose intolerance | Q33993914 | ||
| Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality | Q35846814 | ||
| Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells | Q36566004 | ||
| Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene | Q36832797 | ||
| Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency | Q37175466 | ||
| Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism | Q37370677 | ||
| Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene | Q37372990 | ||
| Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. | Q37381203 | ||
| A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity | Q38331543 | ||
| Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice | Q40019067 | ||
| Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? | Q40758109 | ||
| Transgenic approaches to the pathogenesis of NIDDM. | Q41009892 | ||
| The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family | Q48050897 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | type 2 diabetes | Q3025883 |
| insulin resistance | Q1053470 | ||
| knockout mouse | Q1364740 | ||
| preproinsulin | Q7240673 | ||
| P304 | page(s) | 459-465 | |
| P577 | publication date | 2000-08-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Insights into insulin resistance and type 2 diabetes from knockout mouse models | |
| P478 | volume | 106 |
| Q38882996 | A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice |
| Q85926328 | Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments |
| Q37322732 | Acupuncture Alters Expression of Insulin Signaling Related Molecules and Improves Insulin Resistance in OLETF Rats. |
| Q44108046 | Adiponectin and its receptors: implications for obesity-associated diseases and longevity |
| Q37271252 | Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones |
| Q37177235 | Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance |
| Q36535915 | Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats |
| Q34203330 | Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice |
| Q35043416 | Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? |
| Q37190820 | Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus |
| Q37371324 | Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance. |
| Q58798734 | Blind fish: An eye opener |
| Q44804017 | Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice |
| Q57787528 | Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops) |
| Q42829342 | Chrysanthemum promotes adipocyte differentiation, adiponectin secretion and glucose uptake |
| Q44398258 | Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. |
| Q35022738 | Daily rice intake strongly influences the incidence of metabolic syndrome in Japanese men aged 40-59 years |
| Q42525627 | Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice |
| Q42478561 | Differential sensitivity to adrenergic stimulation underlies the sexual dimorphism in the development of diabetes caused by Irs-2 deficiency |
| Q36175908 | Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells |
| Q24814842 | Environmental contaminants as etiologic factors for diabetes |
| Q26860345 | Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress |
| Q44158440 | Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals. |
| Q37250686 | Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice |
| Q34421519 | Genetic determinants of type 2 diabetes mellitus |
| Q47749706 | Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF‑κB/GLUT‑4. |
| Q41980049 | Guava leaf extracts alleviate fatty liver via expression of adiponectin receptors in SHRSP.Z-Leprfa/Izm rats |
| Q27477554 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3 |
| Q34548619 | Hexosamines as mediators of nutrient sensing and regulation in diabetes. |
| Q41458975 | Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice |
| Q28728262 | Human-specific SNP in obesity genes, adrenergic receptor beta2 (ADRB2), Beta3 (ADRB3), and PPAR γ2 (PPARG), during primate evolution |
| Q34631026 | Humanin and age-related diseases: a new link? |
| Q37605002 | Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic ? Cells during Fasting and in Type 2 Diabetes |
| Q37683511 | IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33. |
| Q34591652 | Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes |
| Q36858473 | Importance of Lean Muscle Maintenance to Improve Insulin Resistance by Body Weight Reduction in Female Patients with Obesity |
| Q30395538 | Improvement of insulin resistance by Cyanidin 3-glucoside, anthocyanin from black beans through the up-regulation of GLUT4 gene expression |
| Q38297185 | Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver |
| Q57281924 | Inferring causal pathways among three or more variables from steady-state correlations in a homeostatic system |
| Q30453548 | Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. |
| Q37532741 | Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus |
| Q37776456 | Insulin resistance at the crossroads of metabolic syndrome: Systemic analysis using microarrays |
| Q38341759 | Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity |
| Q64070399 | Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time |
| Q39194322 | Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance |
| Q34399564 | Mechanisms of dietary response in mice and primates: a role for EGR1 in regulating the reaction to human-specific nutritional content. |
| Q34399523 | Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance |
| Q36054814 | Mechanisms of macrophage activation in obesity-induced insulin resistance |
| Q45976156 | Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. |
| Q41564006 | Methods and models for metabolic assessment in mice |
| Q34077389 | MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. |
| Q36661654 | Molecular backgrounds of age-related osteoporosis from mouse genetics approaches |
| Q42800521 | Molecular cloning and characterization of olive flounder (Paralichthys olivaceus) peroxisome proliferator-activated receptor gamma |
| Q34588917 | Mouse models of insulin resistance |
| Q30447386 | Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism |
| Q35711985 | New insights into the integrated physiology of insulin action |
| Q33577712 | Optimal therapy of type 2 diabetes: a controversial challenge |
| Q43879860 | Organophosphorus insecticide, monocrotophos, possesses the propensity to induce insulin resistance in rats on chronic exposure |
| Q42497461 | Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis |
| Q33997240 | Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance |
| Q40715078 | PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice |
| Q35048456 | PPAR-gamma expression modulates insulin sensitivity in C2C12 skeletal muscle cells |
| Q34546901 | PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors |
| Q35996598 | Pancreatic function, type 2 diabetes, and metabolism in aging |
| Q44517501 | Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. |
| Q37358085 | Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse |
| Q46981242 | Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation |
| Q28365786 | Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis |
| Q39460724 | Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor |
| Q38709913 | Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes |
| Q44972939 | Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion |
| Q48137615 | Quantitative profile of five murine core proteomes using label-free functional proteomics |
| Q33774651 | Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line |
| Q42522475 | Red blood cell Na+/H+ exchange activity is insulin resistant in hypertensive patients |
| Q34148542 | Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. |
| Q35811703 | Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period |
| Q52100116 | Role of PPARgamma in the development of the central nervous system |
| Q41816803 | Role of insulin resistance in the pathogenesis and development of type 2 diabetes in WBN/Kob-Lepr(fa) rats |
| Q37698287 | Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis |
| Q42831990 | SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes |
| Q34481623 | Strategies for treating HIV-related lipodystrophy |
| Q28586697 | Suppression of body fat accumulation in myostatin-deficient mice |
| Q54472913 | TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass. |
| Q47639338 | The Association Between IGF-I and IGFBP-3 and Incident Diabetes in an Older Population of Men and Women in the Cardiovascular Health Study |
| Q44389364 | The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men. |
| Q42835215 | The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits visceral obesity and insulin resistance by upregulating visceral adipose genes involved in fatty acid oxidation |
| Q46423335 | The protective effect of Yi-Qi-Yang-Yin-Ye, a compound of traditional Chinese herbal medicine in diet-induced obese rats |
| Q43257120 | The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus |
| Q37805797 | Tissue specificity on insulin action and resistance: past to recent mechanisms. |
| Q34224255 | Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice |
| Q34076176 | Tissue-specific insulin signaling in the regulation of metabolism and aging |
| Q37867114 | Tissue-specificity of insulin action and resistance. |
| Q34545863 | Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage |
| Q34011043 | Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists |
| Q40761388 | Unraveling the mechanism of action of thiazolidinediones |
Search more.