| Q24323752 | A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family |
| Q48039641 | A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling. |
| Q74326180 | Anti-apoptotic signaling by a colony-stimulating factor-1 receptor/insulin receptor chimera with a juxtamembrane deletion |
| Q42797755 | Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes |
| Q39458647 | Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. |
| Q24548364 | Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function |
| Q33897187 | Biologic functions and signaling of the interleukin-4 receptor complexes |
| Q44804017 | Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice |
| Q38611877 | Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin-IRS2 signals |
| Q42158322 | Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle |
| Q29614735 | Critical nodes in signalling pathways: insights into insulin action |
| Q27619068 | Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1 |
| Q33740861 | Diabetes and the role of inositol-containing lipids in insulin signaling |
| Q48090584 | Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain |
| Q34465504 | Dockers at the crossroads |
| Q28207727 | Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization |
| Q24535902 | Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. |
| Q42030375 | Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activity |
| Q42829998 | Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor |
| Q28647612 | Effect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensor |
| Q39190427 | Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy |
| Q39315669 | Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy |
| Q45142910 | Endurance exercise training increases insulin responsiveness in isolated adipocytes through IRS/PI3-kinase/Akt pathway |
| Q41028627 | Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. |
| Q33830301 | Evolution of the vertebrate insulin receptor substrate (Irs) gene family |
| Q37257933 | Expression and function of the insulin receptor substrate proteins in cancer |
| Q67848550 | Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica |
| Q46550096 | Expression of insulin receptor substrates 1-3, glucose transporters GLUT-1-4, signal regulatory protein 1alpha, phosphatidylinositol 3-kinase and protein kinase B at the protein level in the human testis |
| Q43698049 | Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase |
| Q28138626 | Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1 |
| Q35214648 | Genetic manipulation of the insulin signalling cascade in mice--potential insight into the pathomechanism of type 2 diabetes |
| Q41083088 | Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor. |
| Q37409955 | IGF-IR in neuroprotection and brain tumors |
| Q59088199 | IRS-2 pathways integrate female reproduction and energy homeostasis |
| Q24554363 | IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis |
| Q89586469 | IRS2 depletion inhibits cell proliferation and decreases hormone secretion in mouse granulosa cells |
| Q42817429 | Identification of enhanced serine kinase activity in insulin resistance |
| Q51372137 | Immobilization depresses insulin signaling in skeletal muscle. |
| Q44257211 | Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice |
| Q38297185 | Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver |
| Q28589116 | Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase |
| Q42811045 | Increased tyrosine phosphorylation of the insulin receptor, the insulin receptor substrate-1 and a 73 kDa protein associated with insulin-induced mitogenesis in SV40-transformed 3T3T cells |
| Q37666434 | Inputs and outputs of insulin receptor |
| Q34011039 | Insights into insulin resistance and type 2 diabetes from knockout mouse models |
| Q54117527 | Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system. |
| Q41043761 | Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of advanced glycation end products |
| Q43668023 | Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. |
| Q26823171 | Insulin receptor signaling in normal and insulin-resistant states |
| Q34103184 | Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential |
| Q39457155 | Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling |
| Q34188504 | Insulin receptor substrate polymorphisms and type 2 diabetes mellitus |
| Q42818693 | Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. |
| Q40884659 | Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line |
| Q42446997 | Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells. |
| Q28156047 | Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation |
| Q36324480 | Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts |
| Q28574967 | Insulin receptor substrate-3 functions as transcriptional activator in the nucleus |
| Q40219858 | Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. |
| Q54049445 | Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. |
| Q28576668 | Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases |
| Q33703478 | Insulin signalling: metabolic pathways and mechanisms for specificity |
| Q24291007 | Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins |
| Q41028530 | Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells |
| Q33962150 | Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition |
| Q53433718 | Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse. |
| Q48039922 | Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter |
| Q28296952 | Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology |
| Q37155400 | Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1 |
| Q36255197 | Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton |
| Q37598825 | Involvement of insulin receptor substrate 2 in mammary tumor metastasis |
| Q43512395 | Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture |
| Q22004260 | Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes |
| Q36438742 | Lipid phosphatases as drug discovery targets for type 2 diabetes. |
| Q33716190 | Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer |
| Q41663538 | Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance |
| Q34377069 | Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models |
| Q44268162 | Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation |
| Q42829443 | Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2. |
| Q42816908 | Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes |
| Q37179864 | Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging |
| Q33853693 | Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes |
| Q34034147 | Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications |
| Q38613745 | Opposite effects of insulin on focal adhesion proteins in 3T3-L1 adipocytes and in cells overexpressing the insulin receptor |
| Q33958497 | Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state |
| Q42833982 | Overexpression of Fer increases the association of tyrosine-phosphorylated IRS-1 with P85 phosphatidylinositol kinase via SH2 domain of Fer in transfected cells |
| Q42486150 | Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation |
| Q43293822 | PI3K integrates the effects of insulin and leptin on large-conductance Ca2+-activated K+ channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus |
| Q42991205 | Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling |
| Q44263779 | Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis |
| Q34343619 | Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation |
| Q33588931 | Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance |
| Q35097075 | RETRACTED: Role of microRNA 30a targeting insulin receptor substrate 2 in colorectal tumorigenesis |
| Q33639166 | Recent progress in insulin signal transduction |
| Q41932733 | Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes |
| Q41008812 | Reconstitution of insulin signaling pathways in rat 3Y1 cells lacking insulin receptor and insulin receptor substrate-1. Evidence that activation of Akt is insufficient for insulin-stimulated glycogen synthesis or glucose uptake in rat 3Y1 cells |
| Q42805782 | Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. |
| Q40498051 | Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism |
| Q44565944 | Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes. |
| Q46142489 | Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice |
| Q45095646 | Rosuvastatin may modulate insulin signaling and inhibit atherogenesis beyond its plasma cholesterol-lowering effect in insulin-resistant mice |
| Q24293490 | SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation |
| Q44644463 | Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats |
| Q33855352 | Structure and function of phosphatidylinositol-3,4 kinase |
| Q42186924 | Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells |
| Q33599464 | Syndromes associated with insulin resistance and acanthosis nigricans |
| Q33694174 | Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development |
| Q28284128 | The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling |
| Q28272481 | The IRS-signalling system: a network of docking proteins that mediate insulin action |
| Q35986310 | The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia |
| Q28513514 | The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth |
| Q39576638 | The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin |
| Q33599408 | The role of G proteins in insulin signalling |
| Q58438150 | The role of PI 3-kinase in insulin action |
| Q40884595 | The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes |
| Q37174878 | Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. |
| Q34194701 | Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5 |
| Q24534026 | Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration |
| Q36286218 | Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance |