| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0898-6568(01)00227-3 |
| P698 | PubMed publication ID | 11747984 |
| P2093 | author name string | Graeme R Guy | |
| Chee Wai Fong | |||
| Esther Sook Miin Wong | |||
| Permeen Yusoff | |||
| DhinothKumar Bangarusamy | |||
| P2860 | cites work | Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. | Q47072330 |
| The Drosophila protein Dof is specifically required for FGF signaling | Q48009073 | ||
| The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family | Q48050897 | ||
| Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1. | Q48083183 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. | Q52512624 | ||
| Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif | Q54246424 | ||
| Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells | Q59079799 | ||
| IRS-2 pathways integrate female reproduction and energy homeostasis | Q59088199 | ||
| Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner | Q74485105 | ||
| The PTB Domain: The Name Doesn't Say It All | Q78168527 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| Protein modules and signalling networks | Q27860694 | ||
| Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein | Q28116980 | ||
| SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins | Q28131774 | ||
| The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation | Q28139721 | ||
| The functional significance of Shc in insulin signaling as a substrate of the insulin receptor | Q28143711 | ||
| Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation | Q28145464 | ||
| A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway | Q28240585 | ||
| The IRS-signalling system: a network of docking proteins that mediate insulin action | Q28272481 | ||
| The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R | Q28284797 | ||
| 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice | Q28289491 | ||
| Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok | Q28302094 | ||
| Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein | Q28578484 | ||
| FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation | Q28586482 | ||
| daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans | Q28611331 | ||
| Mechanisms of angiogenesis | Q29547485 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| Wound healing--aiming for perfect skin regeneration | Q29616715 | ||
| Oxidative stress, caloric restriction, and aging | Q29618229 | ||
| The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains | Q29618469 | ||
| From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'. | Q30176018 | ||
| Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling | Q30947583 | ||
| An alternative to SH2 domains for binding tyrosine-phosphorylated proteins | Q34292972 | ||
| Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor | Q34381905 | ||
| Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc. | Q36326107 | ||
| Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells | Q36566004 | ||
| SNT, a Differentiation-Specific Target of Neurotrophic Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells | Q36678095 | ||
| The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif | Q36678826 | ||
| The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein | Q36788339 | ||
| Role of the extracellular matrix in neural crest cell migration. | Q38578946 | ||
| The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential | Q40788805 | ||
| The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival | Q40934242 | ||
| The extracellular matrix in neural crest-cell migration | Q41326371 | ||
| Comparison of the signaling abilities of the Drosophila and human insulin receptors in mammalian cells | Q41349735 | ||
| A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides | Q41356670 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells | Q42795864 | ||
| The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. | Q42804257 | ||
| PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities | Q42820562 | ||
| The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases. | Q47072096 | ||
| Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 | ||
| Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases | Q24299026 | ||
| Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins | Q24313489 | ||
| p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells | Q24315152 | ||
| The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein | Q24315811 | ||
| A Grb2-associated docking protein in EGF- and insulin-receptor signalling | Q24321653 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain | Q24536014 | ||
| FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors | Q24554326 | ||
| A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans | Q24603590 | ||
| Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins | Q24629903 | ||
| Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation | Q24646756 | ||
| Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors | Q27628653 | ||
| Structure and ligand recognition of the phosphotyrosine binding domain of Shc | Q27732196 | ||
| P433 | issue | 1 | |
| P1104 | number of pages | 10 | |
| P304 | page(s) | 11-20 | |
| P577 | publication date | 2002-01-01 | |
| P1433 | published in | Cellular Signalling | Q1524097 |
| P1476 | title | Dockers at the crossroads | |
| P478 | volume | 14 |
| Q24306476 | ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2 |
| Q35076666 | An evolutionary and structural perspective on T cell antigen receptor function |
| Q39817169 | FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway |
| Q28188565 | Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase |
| Q36324505 | Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation |
| Q44770020 | Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor |
| Q37279304 | Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor |
| Q38167994 | Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling |
| Q52726553 | Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. |
| Q39855974 | Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration |
| Q41296343 | The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway |
| Q44653234 | Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations. |
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