| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1003203012 |
| P356 | DOI | 10.1023/A:1006806722619 |
| P3181 | OpenCitations bibliographic resource ID | 4703808 |
| P698 | PubMed publication ID | 9609109 |
| P2093 | author name string | M F White | |
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| P433 | issue | 1-2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 3-11 | |
| P577 | publication date | 1998-05-01 | |
| P1433 | published in | Molecular and Cellular Biochemistry | Q1573176 |
| P1476 | title | The IRS-signalling system: a network of docking proteins that mediate insulin action | |
| P478 | volume | 182 |
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| Q24669996 | Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin |
| Q36438742 | Lipid phosphatases as drug discovery targets for type 2 diabetes. |
| Q53581551 | Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. |
| Q36847534 | Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis |
| Q39128964 | Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease |
| Q37151436 | Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q28213888 | Mechanisms of regulation of cell adhesion and motility by insulin receptor substrate-1 in prostate cancer cells |
| Q28140219 | Met receptor tyrosine kinase: enhanced signaling through adapter proteins |
| Q34031701 | Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training |
| Q38298451 | Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells |
| Q36699198 | Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats |
| Q39377954 | Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are phosphatidylinositol 3-kinase/Akt dependent. |
| Q44268162 | Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation |
| Q80160736 | Molecular mechanism of insulin resistance |
| Q35661518 | Morphine induces desensitization of insulin receptor signaling |
| Q33959860 | Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis |
| Q75266402 | Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia |
| Q43299789 | New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle |
| Q38068803 | New perspectives on the evolution of exaggerated traits |
| Q47293022 | Novel link between inflammation and impaired glucose transport during equine insulin resistance |
| Q38337562 | Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters |
| Q40093480 | Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes |
| Q44119094 | Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis |
| Q40725478 | Nuclear translocation of insulin receptor substrate-1 by the simian virus 40 T antigen and the activated type 1 insulin-like growth factor receptor |
| Q37750871 | Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. |
| Q61857206 | Observations on the effects of Suppressor of Cytokine Signaling 7 (SOCS7) knockdown in breast cancer cells: their in vitro response to Insulin Like Growth Factor I (IGF-I) |
| Q46287259 | Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B. |
| Q34377857 | Orally active insulin mimics: where do we stand now? |
| Q36321986 | PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells |
| Q37992232 | PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis |
| Q34038299 | PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice |
| Q38354027 | PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat. |
| Q35056063 | PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity |
| Q44411048 | Palmitate acutely raises glycogen synthesis in rat soleus muscle by a mechanism that requires its metabolization (Randle cycle). |
| Q34750166 | Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? |
| Q44517501 | Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. |
| Q40654424 | Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes |
| Q42913232 | Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling |
| Q42413368 | Plk1 phosphorylation of IRS2 prevents premature mitotic exit via AKT inactivation |
| Q40606069 | Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. |
| Q42775071 | Production, gene structure and characterization of two orthologs of leptin and a leptin receptor in tilapia |
| Q44658837 | Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and phosphatidylinositol 3-kinase by vanadyl sulfate, a protein tyrosine phosphatase inhibitor |
| Q53574708 | Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase. |
| Q34361038 | Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger of insulin action. Comparative analysis of two kinds of "insulin mediators". |
| Q40707234 | Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes |
| Q36578889 | Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling. |
| Q34343619 | Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation |
| Q39855974 | Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration |
| Q33588931 | Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance |
| Q51803667 | Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. |
| Q40727110 | Rapamycin partially prevents insulin resistance induced by chronic insulin treatment |
| Q41932733 | Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes |
| Q50556514 | Reciprocal interference between insulin and interferon-alpha signaling in hepatic cells: a vicious circle of clinical significance? |
| Q42802992 | Reconstitution of phosphoinositide 3-kinase-dependent insulin signaling in a cell-free system |
| Q42094441 | Reduced modeling of signal transduction - a modular approach |
| Q44263764 | Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells |
| Q33969194 | Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor |
| Q40816834 | Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase. |
| Q35043409 | Regulation of glucose transport in human skeletal muscle |
| Q34750786 | Regulation of insulin action by CEACAM1. |
| Q24296501 | Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP |
| Q32029952 | Regulation of receptor tyrosine kinase signaling by endocytic trafficking |
| Q38864973 | Relationship among plasma adipokines, insulin and androgens level as well as biochemical glycemic and lipidemic markers with incidence of PCOS in women with normal BMI. |
| Q40900484 | Requirement for protein-tyrosine phosphatase SHP-2 in insulin-induced activation of c-Jun NH(2)-terminal kinase |
| Q35233875 | Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children |
| Q34345805 | Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells |
| Q28273765 | Role of pescadillo in the transformation and immortalization of mammalian cells |
| Q38165106 | Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance |
| Q99711301 | Roles of the PTP61F Gene in Regulating Energy Metabolism of Tribolium castaneum (Coleoptera: Tenebrionidae) |
| Q37417126 | SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin |
| Q28508471 | SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility |
| Q47868873 | SREBPs suppress IRS-2-mediated insulin signalling in the liver |
| Q36453242 | Sensing the insulin signaling pathway with an antibody array |
| Q28115837 | Shc and CEACAM1 interact to regulate the mitogenic action of insulin |
| Q90640313 | Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR |
| Q33751847 | Signal transduction pathways that regulate eukaryotic protein synthesis |
| Q33936999 | Signaling pathways mediating insulin-stimulated glucose transport |
| Q34350920 | Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity |
| Q33860499 | Signalling through the insulin receptor |
| Q33591797 | Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance |
| Q32063485 | Spatial compartmentalization of signal transduction in insulin action |
| Q64276327 | Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells |
| Q28348345 | Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1 |
| Q74308850 | Stable plasma membrane expression of the soluble domain of the human insulin receptor in yeast |
| Q27641040 | Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor |
| Q27642840 | Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor |
| Q28613745 | Surfing the insulin signaling web |
| Q37196175 | Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. |
| Q37326060 | T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice |
| Q46835510 | TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes |
| Q26799902 | Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling |
| Q36020398 | Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept |
| Q38224544 | Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2. |
| Q46845226 | The Akt pathway in human breast cancer: a tissue-array-based analysis |
| Q34163416 | The Double-stranded RNA–dependent Protein Kinase Differentially Regulates Insulin Receptor Substrates 1 and 2 in HepG2 Cells |
| Q26744725 | The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism |
| Q42945471 | The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice. |
| Q35576979 | The IGF‐1 receptor in cancer biology |
| Q28088661 | The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins |
| Q78168527 | The PTB Domain: The Name Doesn't Say It All |
| Q52101085 | The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2. |
| Q34103628 | The contradictions of the insulin-like growth factor 1 receptor |
| Q24554210 | The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor |
| Q35214638 | The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle |
| Q28513514 | The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth |
| Q34593973 | The gift of Gab. |
| Q24291162 | The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II |
| Q36219706 | The insulin-like growth factor-I receptor as a target for cancer therapy |
| Q29547860 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer |
| Q37712484 | The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus. |
| Q42808962 | The vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) potentiates tyrosine phosphorylation of the insulin receptor |
| Q38354696 | Theoretical and computational studies of peptides and receptors of the insulin family |
| Q37174878 | Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. |
| Q34224255 | Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice |
| Q34672597 | Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains. |
| Q40371756 | Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling |
| Q40193545 | Transgenic expression and recovery of biologically active recombinant human insulin from Arabidopsis thaliana seeds |
| Q54395756 | Tungstate promotes β-cell survival in Irs2-/- mice. |
| Q36197835 | Turning signals on and off: GLUT4 traffic in the insulin-signaling highway |
| Q35917441 | Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST. |
| Q22011200 | Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein |
| Q34341785 | Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4. |
| Q24534026 | Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration |
| Q35048327 | Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity |
| Q28142652 | Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin |
| Q61810256 | Unraveling the Regulation of Hepatic Gluconeogenesis |
| Q30990290 | Unusual duplication of the insulin-like receptor in the crustacean Daphnia pulex |
| Q44565591 | Up-regulation of phosphatidylinositol 3-kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition |
| Q35221333 | Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases |
| Q37505788 | Vascular actions of insulin with implications for endothelial dysfunction |
| Q37451552 | mTOR in renal cell cancer: modulator of tumor biology and therapeutic target. |
| Q42809294 | mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes |
| Q30165212 | v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras |
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