Tungstate promotes β-cell survival in Irs2-/- mice.

scientific article

Tungstate promotes β-cell survival in Irs2-/- mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00409.2013
P698PubMed publication ID24253047
P5875ResearchGate publication ID258766559

P50authorSusana KalkoQ41049953
Sandra RebuffatQ56523945
Ainhoa GarcíaQ80455186
P2093author name stringJoan J Guinovart
Ramon Gomis
Deborah J Burks
Joana Moitinho Oliveira
Rosa Gasa
Delia Zafra
P2860cites workRsk1 mediates a MEK-MAP kinase cell survival signalQ22253213
GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signallingQ24304350
Disruption of IRS-2 causes type 2 diabetes in miceQ24316112
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesQ24564844
Tungstate reduces the expression of gluconeogenic enzymes in STZ ratsQ27325843
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanismsQ28137802
The IRS-signalling system: a network of docking proteins that mediate insulin actionQ28272481
Cidea-deficient mice have lean phenotype and are resistant to obesityQ28504440
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesQ28506402
Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term studyQ28564460
Role of IGFBP-3 in the regulation of β-cell mass during obesity: adipose tissue/β-cell cross talkQ28566031
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experimentsQ29616371
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
The role of insulin receptor substrate 2 in hypothalamic and beta cell function.Q30475796
Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach.Q33498114
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient miceQ33688527
IRS proteins and beta-cell functionQ34197331
Pdx1 restores beta cell function in Irs2 knockout miceQ34791297
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.Q35880276
Five stages of evolving beta-cell dysfunction during progression to diabetesQ35961960
Relationship between beta-cell mass and diabetes onset.Q36034329
Regulation of pancreatic beta-cell massQ36267776
Tissue-specific roles of IRS proteins in insulin signaling and glucose transportQ36386892
Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell functionQ37169507
Beta cell apoptosis in diabetesQ37424013
Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes MellitusQ37782506
ERK1/2 MAP kinases: structure, function, and regulationQ38008550
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetesQ38322289
Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosisQ39468503
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.Q39895683
Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.Q39946656
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetesQ40156533
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and functionQ40354183
Insulin signal transduction and the IRS proteinsQ41048272
Molybdate and tungstate act like vanadate on glucose metabolism in isolated hepatocytesQ42150877
The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway.Q44553715
Stable and functional regeneration of pancreatic beta-cell population in nSTZ-rats treated with tungstateQ44767287
Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteinsQ44807995
Pancreatic remodeling: beta-cell apoptosis, proliferation and neogenesis, and the measurement of beta-cell mass and of individual beta-cell size.Q45979032
Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistanceQ46332802
Integration of DIGE and bioinformatics analyses reveals a role of the antiobesity agent tungstate in redox and energy homeostasis pathways in brown adipose tissueQ46912061
Tungstate decreases weight gain and adiposity in obese rats through increased thermogenesis and lipid oxidationQ47375837
Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.Q47397864
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.Q48702756
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.Q52174749
Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase PathwaysQ58197201
IRS-2 pathways integrate female reproduction and energy homeostasisQ59088199
P433issue1
P304page(s)E36-47
P577publication date2013-11-19
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleTungstate promotes β-cell survival in Irs2-/- mice
P478volume306

Reverse relations

cites work (P2860)
Q28385348An update to the toxicological profile for water-soluble and sparingly soluble tungsten substances
Q91790389Effects of D-Chiro-Inositol on Glucose Metabolism in db/db Mice and the Associated Underlying Mechanisms
Q35618949Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans.
Q38224544Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.
Q55531998The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice.

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