The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway.

scientific article published on 18 August 2003

The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M308334200
P698PubMed publication ID12925525

P50authorAlbert BarberaQ72108072
Isabel Sanchez-PerezQ73081859
P2093author name stringJoan J Guinovart
Ramon Gomis
Rosario Perona
Martine Caron
Ciro Mercurio
Susanna Baqué
M Carmen Muñoz
Delia Zafra
Jorge E Domínguez
P2860cites workMitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylationQ24528506
Crystal structure and functional analysis of the SurE protein identify a novel phosphatase familyQ27634475
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulinQ28262178
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphataseQ28278415
Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term studyQ28564460
The renaissance of GSK3Q29616725
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.Q30460881
Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats.Q31809629
Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout miceQ33975117
GSK3 takes centre stage more than 20 years after its discoveryQ34374129
Vanadium and tungsten derivatives as antidiabetic agents: a review of their toxic effectsQ34893118
Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucoseQ41328846
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated proteQ41437636
Mutation of tyrosine residues 1162 and 1163 of the insulin receptor affects hormone and receptor internalizationQ41745510
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signallingQ42032355
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cellsQ42808753
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.Q42811852
Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cellsQ42830614
Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytesQ42832240
Inhibition of bacteriophage lambda protein phosphatase by organic and oxoanion inhibitorsQ43853894
Modulation of glucose transporters in rat diaphragm by sodium tungstateQ44428899
Permolybdate and pertungstate--potent stimulators of insulin effects in rat adipocytes: mechanism of actionQ49292358
An application of population kinetics analysis to estimate pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in rats.Q52038356
Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase.Q54154970
Interaction of porcine uterine fluid purple acid phosphatase with vanadate and vanadyl cationQ54255774
Letter: Transition metal ion inhibition of enzyme-catalyzed phosphate ester displacement reactions.Q54719293
The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitroQ58450063
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)42785-42794
P577publication date2003-08-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway
P478volume278

Reverse relations

cites work (P2860)
Q54351172Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes.
Q40035788Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
Q57136256Characterizations and morphology of sodium tungstate particles
Q45285539Effects of sodium tungstate on oxidative stress enzymes in rats
Q28075738Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy
Q38904867In vivo sodium tungstate treatment prevents E-cadherin loss induced by diabetic serum in HK-2 cell line
Q42820960Inhibitory effect of CuSO₄ on α-glucosidase activity in ddY mice
Q46912061Integration of DIGE and bioinformatics analyses reveals a role of the antiobesity agent tungstate in redox and energy homeostasis pathways in brown adipose tissue
Q28577725Internalization of the receptor for advanced glycation end products (RAGE) is required to mediate intracellular responses
Q33498114Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach.
Q47910960Oral tungstate (Na2WO4) exposure reduces adaptive immune responses in mice after challenge
Q35618949Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans.
Q47145300Sodium Tungstate for Promoting Mesenchymal Stem Cell Chondrogenesis
Q43152965Sodium tungstate (Na2WO4) exposure increases apoptosis in human peripheral blood lymphocytes
Q44807995Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
Q46490425Sodium tungstate decreases sucrase and Na+/D-glucose cotransporter in the jejunum of diabetic rats
Q55531998The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice.
Q28649323The elements of life and medicines
Q46592790The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D.
Q54395756Tungstate promotes β-cell survival in Irs2-/- mice.
Q27325843Tungstate reduces the expression of gluconeogenic enzymes in STZ rats
Q35557265Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

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