Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

scientific journal article

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.25.2.819-829.2005
P3181OpenCitations bibliographic resource ID3481083
P932PMC publication ID543412
P698PubMed publication ID15632081

P50authorTony TiganisQ37382684
Sandra GalicQ54345991
Barbara KahnQ60572402
P2093author name stringNicholas K. Tonks
Benjamin G. Neel
Christine Hauser
Fawaz G. Haj
P2860cites workTyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor proteinQ22011200
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1BQ24290779
Insulin signalling and the regulation of glucose and lipid metabolismQ24292020
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblastsQ24292424
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3Q24292506
PTP1B regulates leptin signal transduction in vivoQ24294879
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTPQ24296501
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequenceQ24301399
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphataseQ24308779
Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cellsQ24312499
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatasesQ24323070
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphataseQ24522441
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient miceQ24552910
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transductionQ24607854
The role of protein tyrosine phosphatase 1B in Ras signalingQ24622106
Structure determination of T cell protein-tyrosine phosphataseQ27638439
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatasesQ28186505
Killing the messenger: short RNAs that silence gene expressionQ28207880
Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domainQ28211088
The IRS-signalling system: a network of docking proteins that mediate insulin actionQ28272481
Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LARQ28285845
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistanceQ28363155
Testis determination requires insulin receptor family function in miceQ28512518
The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinasesQ28569180
Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytesQ28572663
Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient miceQ28594549
Insulin signallingQ28611467
Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin actionQ28616328
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B geneQ29618933
The endocrine regulation of aging by insulin-like signalsQ29903591
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) ratsQ33857313
Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascadeQ33942025
Structural and evolutionary relationships among protein tyrosine phosphatase domainsQ34012560
The T-cell protein tyrosine phosphataseQ34038105
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic miceQ34038299
Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptorQ34129090
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.Q34158339
Combinatorial control of the specificity of protein tyrosine phosphatasesQ34180660
PTP1B: from the sidelines to the front lines!Q34209253
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptorQ34381905
Protein-tyrosine phosphatases: emerging targets for therapeutic intervention in type 2 diabetes and related states of insulin resistanceQ34671747
Protein tyrosine phosphatase 1B inhibitors for diabetesQ34810384
Role for neuronal insulin resistance in neurodegenerative diseasesQ36853917
Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.Q38308210
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob miceQ38359290
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesisQ38363967
Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activationQ40786997
Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.Q40807012
Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR.Q41370376
Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptorQ41474091
Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sitesQ41547914
The insulin signalling system and the IRS proteinsQ41555426
The carboxy terminal 110 amino acid portion of the insulin receptor is important for insulin signalling to pyruvate dehydrogenaseQ41589352
Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humansQ41653026
Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mappingQ42803039
Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.Q42826816
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.Q44932599
Role of brain insulin receptor in control of body weight and reproductionQ47229086
Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatasesQ48021665
Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.Q54062879
Characteristics of human erythrocyte insulin receptorsQ67341307
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
Protein tyrosine phosphatase, non-receptor type 1Q21990490
Protein tyrosine phosphatase, non-receptor type 2Q21990494
P304page(s)819–829
P577publication date2005-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleCoordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
P478volume25

Reverse relations

cites work (P2860)
Q60046062A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism
Q40380384A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.
Q92989379Activation of Insulin Signaling in Adipocytes and Myotubes by Sarcopoterium Spinosum Extract
Q39735987Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance
Q34184654Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
Q27023359Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes
Q24310309Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B
Q36512624Central regulation of metabolism by protein tyrosine phosphatases
Q52882634Characterization of PTPN2 and its use as a biomarker.
Q27674636Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity
Q24293674Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase
Q94540673Design and Synthesis of a Library of Thiazolidin-4-one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt to Discover Novel Anti-diabetic Agents
Q37274802Differential regulation of FGFR3 by PTPN1 and PTPN2.
Q24336003Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase
Q30152628Differential regulation of protein tyrosine kinase signaling by Dock and the PTP61F variants
Q30010287Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling
Q37673154Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial
Q52676425Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.
Q41129993Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice
Q33706954Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases
Q33678110Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium
Q38111372H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria
Q43184075IBD candidate genes and intestinal barrier regulation
Q37791747In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis
Q39065291Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice
Q37666434Inputs and outputs of insulin receptor
Q48056892Insulin action in the brain: Roles in energy and glucose homeostasis
Q39668185Insulin immuno-neutralization in fed chickens: effects on liver and muscle transcriptome
Q35279453Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain
Q28278644Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease
Q41550474Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer
Q46776291Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Q33858514Metabolic regulation by protein tyrosine phosphatases
Q90380187Molecular mechanism of the anti-diabetic activity of an identified oligosaccharide from Rosa canina
Q41554019NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation
Q42656002Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B.
Q28239790PTEN is a protein tyrosine phosphatase for IRS1
Q37992232PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
Q36969867PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
Q34271712PTPIP51 in protein interactions: regulation and in situ interacting partners
Q90263941PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer
Q37728541Phosphatase regulation of intercellular junctions
Q36713273Protein tyrosine phosphatase function: the substrate perspective
Q37983900Protein tyrosine phosphatase inhibitors: a patent review (2002 - 2011).
Q26774570Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease
Q37088189Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22
Q24295233Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors
Q40177903Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance
Q33941647Reactive oxygen species enhance insulin sensitivity
Q43673465Reactive oxygen species facilitate the insulin-dependent inhibition of glucagon-induced glucose production in the isolated perfused rat liver
Q39448315Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease
Q40127873Redox-dependent and ligand-independent trans-activation of insulin receptor by globular adiponectin
Q33884112Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway
Q24316395Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase
Q35085007Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation
Q24294324Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Q34270913Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.
Q38105642Substituted oxadiazoles: a patent review (2010 - 2012).
Q34043456Suggestion of suitable animal models for in vivo studies of protein tyrosine phosphatase 1b (PTP1B) inhibitors using computational approaches.
Q90192725Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes
Q37326060T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice
Q46115480T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells.
Q28592080T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis
Q35806647T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts
Q34005525TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
Q33980542TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication
Q36560020TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Q33774262Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
Q90546431The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism
Q36759890The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity
Q52372557The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells.
Q36197835Turning signals on and off: GLUT4 traffic in the insulin-signaling highway
Q24293027VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
Q38732337VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects
Q36325477Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo

Search more.