| scholarly article | Q13442814 |
| P50 | author | Craig B. Thompson | Q5180710 |
| Justin R. Cross | Q41121001 | ||
| Yuji Shi | Q87845895 | ||
| P2093 | author name string | Neal Rosen | |
| Sarat Chandarlapaty | |||
| Junru Wang | |||
| Xuejun Jiang | |||
| P2860 | cites work | Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein | Q22011200 |
| NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN | Q24292919 | ||
| Ubiquitination regulates PTEN nuclear import and tumor suppression | Q24292946 | ||
| HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK | Q24296458 | ||
| Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1 | Q24300146 | ||
| TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta | Q24310394 | ||
| Rak functions as a tumor suppressor by regulating PTEN protein stability and function | Q24312999 | ||
| The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells | Q24615775 | ||
| Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 | Q24623513 | ||
| E3 ligase Nedd4 promotes axon branching by downregulating PTEN | Q24630190 | ||
| Nedd4 controls animal growth by regulating IGF-1 signaling | Q24632761 | ||
| The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization | Q24650856 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
| Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene | Q28349476 | ||
| Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
| Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays | Q28566104 | ||
| Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP | Q28594157 | ||
| The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Q29547302 | ||
| Critical nodes in signalling pathways: insights into insulin action | Q29614735 | ||
| The functions and regulation of the PTEN tumour suppressor | Q29615536 | ||
| Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) | Q29619910 | ||
| Functional analysis of the protein phosphatase activity of PTEN | Q34194118 | ||
| Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN. | Q34272995 | ||
| AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity | Q34511038 | ||
| PTEN and Cancer | Q35113196 | ||
| Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia | Q35666277 | ||
| E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity | Q36070980 | ||
| Post-translational regulation of PTEN. | Q37270440 | ||
| The role of PTEN signaling perturbations in cancer and in targeted therapy | Q37270446 | ||
| PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis | Q37992232 | ||
| Spatial regulation of receptor tyrosine kinases in development and cancer | Q38012616 | ||
| PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity | Q39388363 | ||
| Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. | Q39736424 | ||
| Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. | Q39774233 | ||
| Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling. | Q40135925 | ||
| The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells | Q42481082 | ||
| Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice | Q43726502 | ||
| Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. | Q52180037 | ||
| The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. | Q55476352 | ||
| High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | structural biology | Q908902 |
| P304 | page(s) | 522-527 | |
| P577 | publication date | 2014-05-11 | |
| P1433 | published in | Nature Structural & Molecular Biology | Q1071739 |
| P1476 | title | PTEN is a protein tyrosine phosphatase for IRS1 | |
| P478 | volume | 21 |
| Q36227148 | A PTEN translational isoform has PTEN-like activity |
| Q36345541 | A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism |
| Q59136222 | AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells |
| Q41740974 | Assaying PTEN catalysis in vitro |
| Q42573787 | Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation. |
| Q27315093 | Consumption of distinct dietary lipids during early pregnancy differentially modulates the expression of microRNAs in mothers and offspring |
| Q36072400 | Covalent Tethering of Fragments For Covalent Probe Discovery |
| Q38242086 | Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer |
| Q60923806 | Etiology of Metabolic Syndrome and Dietary Intervention |
| Q54282770 | FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells. |
| Q91583393 | FBXO22 degrades nuclear PTEN to promote tumorigenesis |
| Q90730968 | Improvement of insulin signalling rescues inflammatory cardiac dysfunction |
| Q99415368 | Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling |
| Q26772947 | Inherited PTEN mutations and the prediction of phenotype |
| Q35068543 | Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner |
| Q89998465 | Inhibition of PLK4 might enhance the anti-tumour effect of bortezomib on glioblastoma via PTEN/PI3K/AKT/mTOR signalling pathway |
| Q36744533 | Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation |
| Q36164945 | Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy |
| Q90989940 | LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition |
| Q53834158 | Lycium barbarum Polysaccharide Promotes Nigrostriatal Dopamine Function by Modulating PTEN/AKT/mTOR Pathway in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Murine Model of Parkinson's Disease. |
| Q37696226 | Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement |
| Q94521960 | Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity |
| Q33862755 | NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes |
| Q38295075 | NEDD4: The founding member of a family of ubiquitin-protein ligases |
| Q38886538 | Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. |
| Q36032452 | Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo |
| Q49550289 | PTEN Inhibition in Human Disease Therapy |
| Q92883870 | PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage |
| Q46395242 | PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly |
| Q36378575 | PTEN and NEDD4 in Human Breast Carcinoma |
| Q39201094 | PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells |
| Q45904675 | PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. |
| Q39176925 | PTEN proteoforms in biology and disease |
| Q49887901 | PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy. |
| Q38406254 | PTEN: a yin-yang master regulator protein in health and disease |
| Q38572786 | Phosphatidylinositolphosphate phosphatase activities and cancer |
| Q29248612 | Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases |
| Q48223283 | Regulation of brain insulin signaling: A new function for tau. |
| Q92957648 | Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers |
| Q88955683 | The functions and regulation of the PTEN tumour suppressor: new modes and prospects |
| Q28269344 | The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity |
| Q51115136 | UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis. |
| Q37472232 | Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells. |
| Q47261573 | Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma |
Search more.