| scholarly article | Q13442814 |
| P2093 | author name string | Liu JP | |
| Baker J | |||
| Efstratiadis A | |||
| Robertson EJ | |||
| Perkins AS | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 59-72 | |
| P577 | publication date | 1993-10-08 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) | |
| P478 | volume | 75 |
| Q34287644 | 20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors |
| Q88618163 | 40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1/IGF1R in regulating metabolism using the Cre/loxP system |
| Q35040315 | A 5'-regulatory region and two coding region polymorphisms modulate promoter activity and gene expression of the growth suppressor gene ZBED6 in cattle |
| Q42540944 | A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers. |
| Q59882159 | A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action |
| Q33383201 | A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information. |
| Q30495585 | A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice |
| Q36656841 | A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor |
| Q46921000 | A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. |
| Q37502257 | A genome-wide scan for signatures of selection in Chinese indigenous and commercial pig breeds |
| Q33971079 | A high protein diet during pregnancy affects hepatic gene expression of energy sensing pathways along ontogenesis in a porcine model |
| Q33684671 | A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. |
| Q35080575 | A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. |
| Q28510192 | A murine model for human sepiapterin-reductase deficiency |
| Q37707329 | A new paradigm for the role of aging in the development of skin cancer |
| Q24311441 | A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2 |
| Q41340739 | A novel heterozygous IGF-1 receptor mutation associated with hypoglycemia |
| Q30476716 | A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis |
| Q26995910 | A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation |
| Q38776096 | A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568. |
| Q40345828 | A reappraisal of the role of insulin-like growth factor I in the regulation of human hematopoiesis |
| Q33287220 | A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre |
| Q41611098 | A role for insulin-like growth factor-I in the regulation of Schwann cell survival |
| Q34109393 | A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells |
| Q35601037 | A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes |
| Q33518246 | AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development. |
| Q34098413 | ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response |
| Q33902980 | Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII |
| Q36259415 | Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function |
| Q33651979 | Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain |
| Q36597395 | Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis |
| Q34179807 | Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas |
| Q26269914 | Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10 |
| Q48523634 | Acute Ethanol Increases IGF-I-Induced Phosphorylation of ERKs by Enhancing Recruitment of p52-Shc to the Grb2/Shc Complex |
| Q35225072 | Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair |
| Q37165350 | Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody |
| Q35606971 | Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis |
| Q35640633 | Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice |
| Q38010727 | Administration of growth factors for bone regeneration |
| Q35947448 | Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1 |
| Q28511143 | Akt promotes BMP2-mediated osteoblast differentiation and bone development |
| Q34276940 | Akt/protein kinase B promotes organ growth in transgenic mice |
| Q33303666 | Akt1 in osteoblasts and osteoclasts controls bone remodeling |
| Q33394396 | Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice |
| Q81439353 | Altered expression of type I insulin-like growth factor receptor in Crohn's disease |
| Q36159564 | Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome |
| Q24606199 | Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death |
| Q34344953 | Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice |
| Q38950494 | Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells |
| Q36821086 | An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis |
| Q36617409 | An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol |
| Q24672152 | An alternative, nonapoptotic form of programmed cell death |
| Q47604904 | An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. |
| Q33635803 | An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice |
| Q49022188 | An experimental model of partial insulin-like growth factor-1 deficiency in mice |
| Q38079231 | Anabolic effects of IGF-1 signaling on the skeleton |
| Q33975671 | Analysis of the dynamics of limb transcriptomes during mouse development |
| Q34539063 | Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy |
| Q35586419 | Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB. |
| Q34793925 | Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes |
| Q41867706 | Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2. |
| Q35685364 | Arsenic exposure to killifish during embryogenesis alters muscle development |
| Q28396530 | Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential |
| Q36912226 | Association between polymorphisms in genes related to common adult diseases and fetal growth |
| Q92066719 | Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population |
| Q24307564 | Association of insulin receptor substrate 1 with simian virus 40 large T antigen |
| Q35083425 | Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women |
| Q55717962 | Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system. |
| Q36807644 | Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth |
| Q38566647 | Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development |
| Q33873341 | Autocrine/paracrine role of insulin-related growth factors in neurogenesis: local expression and effects on cell proliferation and differentiation in retina |
| Q62083307 | Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism |
| Q37305891 | Autophagy resolves early retinal inflammation in Igf1-deficient mice |
| Q42176265 | Beckwith-Wiedemann syndrome and the insulin-like growth factor-II gene. Does the genotype explain the phenotype? |
| Q36883554 | Bioactive factors for tissue regeneration: state of the art. |
| Q33588606 | Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout |
| Q37586295 | Blastocyst injection of embryonic stem cells: a simple approach to unveil mechanisms of corrections in mouse models of human disease |
| Q91627122 | Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy |
| Q41918229 | Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistry. |
| Q33947306 | Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury |
| Q36145137 | Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms. |
| Q27332330 | Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism |
| Q64899520 | Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms. |
| Q50611250 | CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development. |
| Q36788885 | Cardiac myocyte cell cycle control in development, disease, and regeneration |
| Q27325791 | Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo |
| Q33285306 | Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. |
| Q36510617 | Characterizing a distal muscle enhancer in the mouse Igf2 locus |
| Q37124617 | Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum |
| Q28484039 | Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation |
| Q81189651 | Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene |
| Q53881985 | Cloning of porcine IGF1 receptor cDNA and detection of sequence polymorphisms using RT-PCR. |
| Q50421448 | Comparative Transcriptome Analysis Reveals Growth-Related Genes in Juvenile Chinese Sea Cucumber, Russian Sea Cucumber, and Their Hybrids |
| Q35971938 | Comparative endocrinology of aging and longevity regulation |
| Q36618602 | Comparison of the genome-wide DNA methylation profiles between fast-growing and slow-growing broilers |
| Q33862702 | Components of the hematopoietic compartments in tumor stroma and tumor-bearing mice |
| Q48121930 | Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking |
| Q34046618 | Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion |
| Q33865210 | Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system |
| Q31032454 | Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts |
| Q36670657 | Contributions of the Insulin/Insulin-Like Growth Factor-1 Axis to Diabetic Osteopathy |
| Q44013294 | Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscle. |
| Q36360388 | Coordinate control of muscle cell survival by distinct insulin-like growth factor activated signaling pathways |
| Q33826301 | Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. |
| Q37277344 | Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells |
| Q37777053 | Current, new and future treatments of osteoporosis |
| Q28510829 | Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism |
| Q35153827 | DNA damage and ageing: new-age ideas for an age-old problem |
| Q42842551 | DNA demethylation enhances myoblasts hypertrophy during the late phase of myogenesis activating the IGF-I pathway |
| Q30979460 | Data Mining of Determinants of Intrauterine Growth Retardation Revisited Using Novel Algorithms Generating Semantic Maps and Prototypical Discriminating Variable Profiles |
| Q37456221 | Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling. |
| Q35266398 | Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling |
| Q33690540 | Decorin differentially modulates the activity of insulin receptor isoform A ligands. |
| Q39738488 | Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor |
| Q36494504 | Defining Akt actions in muscle differentiation. |
| Q74538288 | Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice |
| Q37429072 | Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities |
| Q33625989 | Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? |
| Q35651375 | Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in non-small cell lung cancer (NSCLC) cells |
| Q35447657 | Detection of genomic imbalances by array based comparative genomic hybridisation in fetuses with multiple malformations |
| Q36899863 | Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells |
| Q35810061 | Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy. |
| Q41438314 | Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. |
| Q35667262 | Dexamethasone and BCAA Failed to Modulate Muscle Mass and mTOR Signaling in GH-Deficient Rats |
| Q36836772 | Dichotomy of decorin activity on the insulin-like growth factor-I system |
| Q34148644 | Dietary Supplements and Team-Sport Performance |
| Q48130018 | Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells. |
| Q37648847 | Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro |
| Q37219630 | Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice |
| Q40438917 | Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network |
| Q41929403 | Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice. |
| Q39262104 | Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells |
| Q64054006 | Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development |
| Q36566004 | Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells |
| Q34062919 | Discovery and refinement of muscle weight QTLs in B6 × D2 advanced intercross mice |
| Q35850859 | Disproportionate growth in mice with Igf-2 transgenes |
| Q35436183 | Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development |
| Q24642008 | Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice |
| Q33890035 | Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase |
| Q41221060 | Distinct 15q genotypes in Russell-Silver and ring 15 syndromes |
| Q34245339 | Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. |
| Q27314852 | Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? |
| Q37736322 | Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. |
| Q30829981 | Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway |
| Q33963275 | Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways. |
| Q24567609 | Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice |
| Q35838980 | Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels |
| Q35965439 | Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. |
| Q35971304 | Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy |
| Q36846737 | Early fetal hypoxia leads to growth restriction and myocardial thinning |
| Q37530239 | Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice |
| Q30524175 | Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten |
| Q34043294 | Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis |
| Q41387373 | Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B. |
| Q36653985 | Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts |
| Q42838174 | Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. |
| Q51980071 | Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice. |
| Q34610063 | Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats. |
| Q55397343 | Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice. |
| Q28478640 | Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study |
| Q45563779 | Effects of high-tryptophan diet on pre- and postnatal development in rats: a morphological study. |
| Q37369109 | Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products |
| Q37101800 | Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver |
| Q36714137 | Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model |
| Q37361963 | Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency |
| Q37097739 | Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens |
| Q33644001 | Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice |
| Q35155509 | Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. |
| Q34161867 | Emerging therapeutic opportunities for skeletal restoration |
| Q53112042 | Endocrine Control of Growth. |
| Q26827346 | Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health |
| Q42319588 | Endothelin signaling regulates mineralization and posttranscriptionally regulates SOST in TMOb cells via miR 126-3p |
| Q41818572 | Enzymic characterization in vitro of recombinant proprotein convertase PC4. |
| Q35211013 | EphrinA/EphA signal facilitates insulin-like growth factor-I-induced myogenic differentiation through suppression of the Ras/extracellular signal-regulated kinase 1/2 cascade in myoblast cell lines |
| Q41882225 | Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation |
| Q36588519 | Epidermal stem cells are retained in vivo throughout skin aging |
| Q35215689 | Epigenetics and transgenerational inheritance in domesticated farm animals |
| Q34357434 | Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth |
| Q34550563 | Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation |
| Q41817667 | Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function |
| Q37279165 | Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus |
| Q41178427 | Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels |
| Q36001447 | Evidence that IGF-binding protein-5 functions as a growth factor |
| Q35789478 | Exogenous fibroblast growth factor-10 induces cystic lung development with altered target gene expression in the presence of heparin in cultures of embryonic rat lung |
| Q38844094 | Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies |
| Q37034897 | Expanding the mind: insulin-like growth factor I and brain development |
| Q38803593 | Experimental approach to IGF-1 therapy in CCl4-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency. |
| Q33884308 | Expression Profiles of the Insulin-like Growth Factor System Components in Liver Tissue during Embryonic and Postnatal Growth of Erhualian and Yorkshire Reciprocal Cross F1 Pigs. |
| Q48799300 | Expression and distribution of IGF-1 receptors containing a beta-subunit variant (betagc) in developing neurons. |
| Q37157828 | Expression and location of alpha-fetoprotein during rat colon development |
| Q45106771 | Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord |
| Q36816503 | Expression of multiple insulin and insulin-like growth factor receptor genes in salmon gill cartilage |
| Q50768825 | Expression patterns of insulin-like growth factor system members and their correlations with growth and carcass traits in Landrace and Lantang pigs during postnatal development. |
| Q37024196 | Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cord-injured mice |
| Q46693569 | FGF receptors control alveolar elastogenesis. |
| Q39871445 | Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes |
| Q37669668 | Fat tissue and long life. |
| Q34127008 | Feed allowance and maternal backfat levels during gestation influence maternal cortisol levels, milk fat composition and offspring growth |
| Q47648105 | Female Fertility: It Takes Two to Tango |
| Q37881301 | Ferlin proteins in myoblast fusion and muscle growth. |
| Q33615109 | Fetal Leydig cell origin and development |
| Q33788233 | Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis |
| Q34214605 | Fine-mapping of muscle weight QTL in LG/J and SM/J intercrosses |
| Q37590300 | From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis |
| Q47095382 | Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy |
| Q38485815 | Functional and transcriptomic analysis of the regulation of osteoblasts by mechano-growth factor E peptide |
| Q38833954 | Functional characterization and molecular mechanism exploration of three granulin epithelin precursor splice variants in biomineralization of the pearl oyster Pinctada fucata |
| Q92187401 | Funerals and Feasts: The Immunological Rites of Cell Death |
| Q37351190 | G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells |
| Q30480141 | GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion |
| Q36324505 | Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation |
| Q37707054 | Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors. |
| Q37350786 | Gene and protein expression profiles in the foetal liver of the pregnant rat fed a low protein diet. |
| Q34574197 | Gene regulation by growth hormone |
| Q40564585 | Gene-targeting approaches in the study of cellular processes involved in growth or differentiation. Advances in the analysis of oncogenes, tumour-suppressor genes, cytokine/receptor systems and developmental control genes |
| Q91667304 | Genetic Engineering in Animal Models |
| Q34474052 | Genetic engineering in mice: impact on insulin signalling and action. |
| Q28066570 | Genetic insights into the mechanisms of Fgf signaling |
| Q40857246 | Genetic manipulation of insulin action and beta-cell function in mice |
| Q34180527 | Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice |
| Q35972282 | Genetic regulation of the growth plate |
| Q36044750 | Genetics of type 2 diabetes mellitus: status and perspectives |
| Q33975045 | Genetics, chemistry, and function of the IGF/IGFBP system |
| Q34561907 | Genome-wide analysis reveals selection for important traits in domestic horse breeds. |
| Q47926307 | Genome-wide enrichment of damaging de novo variants in patients with isolated and complex congenital diaphragmatic hernia. |
| Q27341203 | Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear |
| Q37289586 | Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis |
| Q37092115 | Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth |
| Q93055189 | Glucosamine Supplementation in Premating Drinking Water Improves Within-Litter Birth Weight Uniformity of Rats Partly through Modulating Hormone Metabolism and Genes Involved in Implantation |
| Q91644879 | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
| Q34418716 | Growth factor control of bone mass |
| Q38340724 | Growth factors in gliomas: antisense and dominant negative mutant strategies |
| Q26852243 | Growth factors, nutrient signaling, and cardiovascular aging |
| Q36773725 | Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth |
| Q36578881 | Growth hormone regulation of insulin-like growth factor-I gene expression may be mediated by multiple distal signal transducer and activator of transcription 5 binding sites |
| Q35305216 | Growth hormone, insulin-like growth factor-1 and the aging brain. |
| Q37147591 | Growth hormone, insulin-like growth factors, and the skeleton |
| Q74243018 | Growth promoting effects of human placental lactogen during early organogenesis: a link to insulin-like growth factors |
| Q34435604 | Growth regulatory factors and bone |
| Q37589827 | Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. |
| Q64272032 | Growth signaling and longevity in mouse models |
| Q48179882 | Gut Microbiota and IGF-1. |
| Q37171043 | Hair biology: an update |
| Q35485124 | Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. |
| Q39679566 | Helianthin induces antiproliferative effect on human glioblastoma cells in vitro |
| Q35257006 | High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice |
| Q27303562 | High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo |
| Q40278526 | Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice |
| Q90339790 | Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes |
| Q35322124 | Hormonal control of aging in rodents: the somatotropic axis |
| Q46935133 | Hormonal regulation of male reproductive tract development |
| Q35240427 | How IGF-1 activates its receptor |
| Q92783187 | Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters |
| Q47366049 | Human IGF-I propeptide A promotes articular chondrocyte biosynthesis and employs glycosylation-dependent heparin binding |
| Q34920315 | Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. |
| Q26822806 | Human conditions of insulin-like growth factor-I (IGF-I) deficiency |
| Q37149891 | IGF ligand and receptor regulation of mammary development |
| Q35878802 | IGF-1 Receptor Insufficiency Leads to Age-Dependent Attenuation of Osteoblast Differentiation |
| Q36862625 | IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms |
| Q35229825 | IGF-1 and bone: New discoveries from mouse models |
| Q48570233 | IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells |
| Q38960055 | IGF-1 in retinopathy of prematurity, a CNS neurovascular disease |
| Q30846570 | IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture. |
| Q34958659 | IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer |
| Q38429301 | IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration. |
| Q36488507 | IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway |
| Q35036607 | IGF-1R signaling is essential for the proliferation of cultured mouse spermatogonial stem cells by promoting the G2/M progression of the cell cycle |
| Q55259134 | IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? |
| Q37076743 | IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury |
| Q36320501 | IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors. |
| Q41934628 | IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand |
| Q43252033 | IGF-I overexpression does not promote compensatory islet cell growth in diet-induced obesity |
| Q33918687 | IGF-I receptor signalling in transformation and differentiation |
| Q42124990 | IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. |
| Q34925236 | IGF-I-induced differentiation of L6 myogenic cells requires the activity of cAMP-phosphodiesterase. |
| Q26768613 | IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain |
| Q41594839 | IGF-II promotes stemness of neural restricted precursors. |
| Q37409955 | IGF-IR in neuroprotection and brain tumors |
| Q33933338 | IGF-IR signal transduction protein content and its activation by IGF-I in human placentas: relationship with gestational age and birth weight |
| Q37271044 | IGF-IR tyrosine kinase interacts with NPM-ALK oncogene to induce survival of T-cell ALK+ anaplastic large-cell lymphoma cells |
| Q33653594 | IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors. |
| Q34966710 | IGF-binding protein-2 protects against the development of obesity and insulin resistance |
| Q47794618 | IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice |
| Q34594074 | IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor |
| Q28591416 | IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop |
| Q34728942 | IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma |
| Q52319914 | IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. |
| Q21134736 | Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study |
| Q48863952 | Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration. |
| Q34994347 | Identification of differentially regulated secretome components during skeletal myogenesis |
| Q35793734 | Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene |
| Q81739215 | Igf-I and postnatal growth of weaver mutant mice |
| Q91989660 | Igf1R/InsR function is required for axon extension and corpus callosum formation |
| Q27334381 | Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin |
| Q41650683 | Immunobiology of gliomas: new perspectives for therapy |
| Q38781464 | Impact of placental insufficiency on fetal skeletal muscle growth |
| Q51779098 | Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats. |
| Q34305212 | Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization |
| Q42576112 | Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy. |
| Q38763958 | Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan |
| Q24633385 | Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1 |
| Q30826617 | In vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene. |
| Q44847915 | In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system |
| Q36739410 | Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. |
| Q36125966 | Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea. |
| Q34981199 | Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression |
| Q40601598 | Inducible expression of dominant negative insulin-like growth factor I receptor in MCF-7 breast cancer cells |
| Q52345798 | Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin. |
| Q37382242 | Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). |
| Q34151181 | Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts |
| Q28083759 | Inflammation induced loss of skeletal muscle |
| Q41661114 | Inflammatory Diseases and Growth: Effects on the GH-IGF Axis and on Growth Plate |
| Q36552308 | Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression |
| Q42036660 | Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation |
| Q33925323 | Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach |
| Q36583516 | Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer |
| Q33911127 | Insulin and IGF receptor signalling in neural-stem-cell homeostasis. |
| Q33883451 | Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription |
| Q35813635 | Insulin like growth factor-1 and insulin-like growth factor binding proteins: their possible roles in both maintaining normal retinal vascular function and in promoting retinal pathology |
| Q33970422 | Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone |
| Q33858986 | Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. |
| Q30468589 | Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function |
| Q28533530 | Insulin receptor substrate 2 is required for testicular development |
| Q28156047 | Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation |
| Q34789045 | Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression |
| Q91594974 | Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior |
| Q52728979 | Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A. |
| Q37617486 | Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging |
| Q47147004 | Insulin-Like Growth Factor Binding Protein-6 Alters Skeletal Muscle Differentiation of Human Mesenchymal Stem Cells |
| Q64235388 | Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor |
| Q42275283 | Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis |
| Q64966018 | Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases. |
| Q64068201 | Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine |
| Q60927515 | Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord |
| Q36629279 | Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo |
| Q36372649 | Insulin-like growth factor (IGF) binding protein-5 blocks skeletal muscle differentiation by inhibiting IGF actions |
| Q28584984 | Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination |
| Q34158381 | Insulin-like growth factor (IGF)-I gene deletion |
| Q22009148 | Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model |
| Q36906898 | Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age. |
| Q28073109 | Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development |
| Q33846069 | Insulin-like growth factor 1 physiology: lessons from mouse models |
| Q28512393 | Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation |
| Q35382945 | Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin |
| Q28511831 | Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis |
| Q28351447 | Insulin-like growth factor I alters renal function and stimulates renin secretion in late gestation fetal sheep |
| Q35597311 | Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. |
| Q36569121 | Insulin-like growth factor I receptor signaling in transformation by src oncogenes |
| Q34321021 | Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant |
| Q33962150 | Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition |
| Q33636341 | Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells |
| Q36105416 | Insulin-like growth factor II stimulates cell proliferation through the insulin receptor |
| Q42474674 | Insulin-like growth factor binding protein-3 (IGFBP-3) localizes to and modulates proliferative epidermal keratinocytes in vivo |
| Q35942750 | Insulin-like growth factor binding protein-5 in osteogenesis: facilitator or inhibitor? |
| Q36236830 | Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism |
| Q40607017 | Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer |
| Q42396741 | Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival |
| Q37773265 | Insulin-like growth factor receptor type I as a target for cancer therapy |
| Q51837006 | Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. |
| Q47074173 | Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression |
| Q37094666 | Insulin-like growth factor system regulates oligodendroglial cell behavior: therapeutic potential in CNS. |
| Q35597565 | Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination |
| Q38358901 | Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts |
| Q34201012 | Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure |
| Q36973428 | Insulin-like growth factor-1 in CNS and cerebrovascular aging |
| Q34110794 | Insulin-like growth factor-1 receptor is regulated by microRNA-133 during skeletal myogenesis |
| Q34676029 | Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells |
| Q37418930 | Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review |
| Q33986884 | Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence |
| Q34429527 | Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor |
| Q37326531 | Insulin-like growth factor-I and bone: lessons from mice and men. |
| Q45879665 | Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2. |
| Q57463379 | Insulin-like growth factor-I is required to maintain muscle volume in adult mice |
| Q48974747 | Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. |
| Q73168304 | Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development |
| Q33890792 | Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? |
| Q28512324 | Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice |
| Q30854620 | Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation |
| Q33962148 | Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice |
| Q36629298 | Insulin-like growth factor-binding protein-5 inhibits osteoblast differentiation and skeletal growth by blocking insulin-like growth factor actions |
| Q33966727 | Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21 |
| Q42694736 | Insulin-like growth factors I and II in starry flounder (Platichthys stellatus): molecular cloning and differential expression during embryonic development |
| Q47759714 | Insulin-like growth factors and pancreas beta cells |
| Q55449613 | Insulin-like growth factors and their binding proteins: Potential relevance to reproductive physiology. |
| Q27690674 | Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review) |
| Q37034921 | Insulin-like growth factors in the peripheral nervous system. |
| Q52329568 | Insulin-like growth factors: actions on the skeleton. |
| Q36740460 | Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production |
| Q34477622 | Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans. |
| Q37696477 | Integrating metabolism and longevity through insulin and IGF1 signaling |
| Q39668813 | Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex-Linked Dwarf Chickens |
| Q36435256 | Interleukin-11 alters placentation and causes preeclampsia features in mice |
| Q43166019 | Intestinal hormones and growth factors: effects on the small intestine |
| Q92291439 | Intrauterine Twin Discordancy and Partial Postnatal Catch-up Growth in a Girl with a Pathogenic IGF1R Mutation |
| Q55061645 | Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner. |
| Q36197145 | Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation |
| Q35695329 | Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development |
| Q38926261 | Key proteins and pathways that regulate lifespan |
| Q61448077 | Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age |
| Q33777892 | Knock your SOCS off! |
| Q28484897 | Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis |
| Q36932274 | Lack of Association between Pre-Operative Insulin-Like Growth Factor-1 and the Risk of Post-Operative Delirium in Elderly Chinese Patients |
| Q24672400 | Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies |
| Q35173262 | Lifespan and glucose metabolism in insulin receptor mutant mice |
| Q34722516 | Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function. |
| Q35568265 | Lin28 promotes the proliferative capacity of neural progenitor cells in brain development |
| Q35748002 | Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. |
| Q37648028 | Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. |
| Q36392687 | Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice |
| Q28595068 | Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia |
| Q34385827 | Long range interactions regulate Igf2 gene transcription during skeletal muscle differentiation |
| Q33689399 | Long-term IGF-I exposure decreases autophagy and cell viability |
| Q33236883 | Long-term maintenance of in vitro cultured honeybee (Apis mellifera) embryonic cells |
| Q33849416 | Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A. |
| Q35080440 | Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation |
| Q35720274 | Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo |
| Q55034610 | Lost in translation: The 3'-UTR of IGF1R as an ancient long noncoding RNA. |
| Q36006630 | Low Insulin-Like Growth Factor-1 Level in Obesity Nephropathy: A New Risk Factor? |
| Q35288507 | Low birthweight and adult insulin resistance: the "catch-up growth" hypothesis |
| Q37423533 | Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. |
| Q35922155 | Lung organogenesis |
| Q39816876 | MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2. |
| Q28589862 | MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling |
| Q39035483 | Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses |
| Q34421842 | Macrophages recruited via CCR2 produce insulin‐like growth factor‐1 to repair acute skeletal muscle injury |
| Q35096127 | Mammalian neural stem-cell renewal: nature versus nurture |
| Q89313055 | Maternal exercise in rats upregulates the placental insulin-like growth factor system with diet- and sex-specific responses: minimal effects in mothers born growth restricted |
| Q37016791 | Maternal protein restriction regulates IGF2 system in placental labyrinth |
| Q35065101 | Maternal-placental-fetal interactions in the endocrine regulation of fetal growth: role of somatotrophic axes. |
| Q40195910 | Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3. |
| Q33957805 | Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I. |
| Q34008357 | Mechanical-tactile stimulation (MTS) intervention in a neonatal stress model improves long-term outcomes on bone |
| Q28385366 | Mechanisms of action of therapeutic antibodies for cancer |
| Q36755738 | Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects. |
| Q35660067 | Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation |
| Q48378396 | Messing with metabolism: lessons from an IUGR fetus |
| Q41054274 | Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906. |
| Q28590546 | Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth |
| Q37670847 | Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span |
| Q34282551 | MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer |
| Q28085566 | Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans |
| Q33821617 | Minireview: mechanisms of growth hormone-mediated gene regulation |
| Q54957106 | MitoQ supplementation prevent long-term impact of maternal smoking on renal development, oxidative stress and mitochondrial density in male mice offspring. |
| Q48008820 | Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats |
| Q58776408 | Molecular Signatures of the Insulin-like Growth Factor 1-mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers |
| Q36879252 | Molecular and functional characterizations of the association and interactions between nucleophosmin-anaplastic lymphoma kinase and type I insulin-like growth factor receptor |
| Q27006868 | Molecular basis of physiological heart growth: fundamental concepts and new players |
| Q35893223 | Molecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures |
| Q34655565 | Molecular insights into insulin action and secretion |
| Q35469289 | Molecular mechanism of size control in development and human diseases |
| Q90406506 | Molecular pathogenesis of fracture nonunion |
| Q40585555 | More to learn from gene knockouts |
| Q40413498 | Mosaic analysis of insulin receptor function |
| Q35027903 | Motor neuron trophic factors: Therapeutic use in ALS? |
| Q27009396 | Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle |
| Q40879623 | Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy |
| Q37511690 | Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions |
| Q36941459 | Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle |
| Q34918405 | Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I. |
| Q34787562 | Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle |
| Q34459252 | Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables |
| Q48546118 | Myelination is altered in insulin-like growth factor-I null mutant mice. |
| Q47357067 | Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro |
| Q33752882 | Myoferlin is required for insulin-like growth factor response and muscle growth |
| Q28072348 | NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? |
| Q24632761 | Nedd4 controls animal growth by regulating IGF-1 signaling |
| Q30451424 | Neurodevelopmental effects of insulin-like growth factor signaling |
| Q64076560 | Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1−/− Mouse |
| Q28589935 | Nocturnin Suppresses Igf1 Expression in Bone by Targeting the 3′ Untranslated Region of Igf1 mRNA |
| Q91846314 | Nonclassical GH Insensitivity: Characterization of Mild Abnormalities of GH Action |
| Q36394699 | Normal growth and development in the absence of hepatic insulin-like growth factor I |
| Q47306340 | Normal growth spurt and final height despite low levels of all forms of circulating insulin-like growth factor-I in a patient with acid-labile subunit deficiency |
| Q50714896 | Novel demonstration of a physiologic/pharmacologic role of insulin-like growth factor-1 in ovulation in rats and action on cumulus oophorus. |
| Q93369636 | Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth† |
| Q36292251 | Nutrition regulation of male accessory gland growth and maturation in Tribolium castaneum |
| Q37258163 | Nutrition, insulin-like growth factor-1 and retinopathy of prematurity |
| Q73488347 | Nutritional causes of impaired fetal growth and their treatment |
| Q71707226 | Nutritional insult and recovery in the neonatal rat cerebellum: insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) |
| Q35003838 | Nutritionally-induced catch-up growth |
| Q39456761 | O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. |
| Q49887886 | Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway |
| Q26800197 | Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray? |
| Q39750828 | Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation |
| Q33833669 | Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle regulatory retinoblastoma protein in skeletal myoblasts |
| Q35001349 | Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice |
| Q35786221 | Overexpression of insulin-like growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts |
| Q36943053 | Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice |
| Q36009698 | Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice |
| Q58103821 | Oversupplying metabolizable protein in late gestation for beef cattle: Effects on postpartum ruminal fermentation, blood metabolites, skeletal muscle catabolism, colostrum composition, milk yield and composition, and calf growth performance |
| Q34617964 | PAPP-A: a new anti-aging target? |
| Q28239790 | PTEN is a protein tyrosine phosphatase for IRS1 |
| Q89749129 | Paracrine signaling in islet function and survival |
| Q28592704 | Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice |
| Q36535001 | Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation |
| Q24673085 | Parental antagonism, relatedness asymmetries, and genomic imprinting |
| Q41383801 | Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins |
| Q37574787 | Pathophysiology of acute kidney injury |
| Q30009184 | Phelan-McDermid Syndrome and SHANK3: Implications for Treatment. |
| Q34008775 | Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling |
| Q28727690 | Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice |
| Q36766264 | Phenotypic alterations in insulin-deficient mutant mice. |
| Q33636392 | Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells |
| Q34377345 | Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth |
| Q74453906 | Pituitary Insulin: Insulin-Like Growth Factors |
| Q33344250 | Placental determinants of fetal growth: identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks |
| Q38880458 | Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. |
| Q30850732 | Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits |
| Q36655837 | Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice |
| Q40962570 | Potential role of insulin-like growth factor binding protein-4 in the uncoupling of bone turnover in multiple myeloma |
| Q36742290 | Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity |
| Q33989224 | Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism |
| Q34466729 | Production of zebrafish germ-line chimeras from embryo cell cultures |
| Q36237537 | Proliferation precedes differentiation in IGF-I-stimulated myogenesis |
| Q33569743 | Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway. |
| Q33780757 | Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation |
| Q34477488 | Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo |
| Q35918864 | Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation |
| Q35325547 | Quantitative phosphoproteomics analysis reveals a key role of insulin growth factor 1 receptor (IGF1R) tyrosine kinase in human sperm capacitation |
| Q34432036 | Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice |
| Q34301920 | RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth |
| Q30360015 | RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family. |
| Q30483747 | RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. |
| Q37831148 | Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma |
| Q50741812 | Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2. |
| Q36807298 | Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior |
| Q36251999 | Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. |
| Q28083996 | Regulation of Long Bone Growth in Vertebrates; It Is Time to Catch Up |
| Q42824894 | Regulation of NIH-3T3 cell G1 phase transit by serum during exponential growth. |
| Q37246697 | Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network |
| Q36231054 | Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size |
| Q36325079 | Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors |
| Q36736100 | Regulation of muscle mass by growth hormone and IGF-I. |
| Q41157691 | Regulation of oligodendrocyte development and CNS myelination by growth factors: prospects for therapy of demyelinating disease |
| Q36734567 | Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. |
| Q35128706 | Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models |
| Q28589630 | Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells |
| Q33641396 | Rescue of developmental defects by blastocyst stem cell injection: towards elucidation of neomorphic corrective pathways |
| Q37237012 | Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. |
| Q28509294 | Role for Akt3/protein kinase Bgamma in attainment of normal brain size |
| Q40468931 | Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. |
| Q30481820 | Role of IGF signaling in olfactory sensory map formation and axon guidance |
| Q54979444 | Role of IGF-1R in ameliorating apoptosis of GNE deficient cells. |
| Q36066585 | Role of IGF-I in follistatin-induced skeletal muscle hypertrophy |
| Q28082188 | Role of IGF-I signaling in muscle bone interactions |
| Q48526161 | Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants |
| Q37091119 | Role of insulin-like growth factor 1 and phosphoinositide 3-kinase in a setting of heart disease |
| Q38006439 | Role of insulin-like growth factor-1 in the regulation of skeletal growth |
| Q33853206 | Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis |
| Q34345805 | Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells |
| Q39311418 | Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation |
| Q40664859 | Role of protein kinase C during insulin mediated skeletal muscle cell spreading |
| Q33883849 | Role of receptor tyrosine kinases and their ligands in glioblastoma |
| Q24645123 | Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. |
| Q64078621 | Roles of Type 1 Insulin-Like Growth Factor (IGF) Receptor and IGF-II in Growth Regulation: Evidence From a Patient Carrying Both an 11p Paternal Duplication and 15q Deletion |
| Q26795757 | Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease |
| Q30446473 | Running on empty: how p53 controls INS/IGF signaling and affects life span |
| Q40540364 | Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling |
| Q24537266 | SH2-B is required for both male and female reproduction |
| Q42371007 | SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes |
| Q33816665 | Satellite cells and the muscle stem cell niche |
| Q28504582 | Scaffold attachment factor B1 functions in development, growth, and reproduction |
| Q38805063 | Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics |
| Q30374737 | Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. |
| Q30666846 | Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. |
| Q36201972 | Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth |
| Q34698741 | Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner |
| Q37283796 | Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions |
| Q37123969 | Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism |
| Q71449288 | Serum levels of insulin-like growth factor-I, -II and insulin-like growth factor binding proteins -2 and -3 in children with acute lymphoblastic leukaemia |
| Q24816701 | Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle |
| Q36084781 | Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain |
| Q36696132 | Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor |
| Q35749349 | SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice. |
| Q28252023 | Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias |
| Q39527508 | Skeletal effects of growth hormone and insulin-like growth factor-I therapy. |
| Q37326925 | Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor |
| Q47756591 | Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. |
| Q28287572 | Skin gammadelta T-cell functions in homeostasis and wound healing |
| Q30395770 | Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer |
| Q92244210 | Small molecules for mesenchymal stem cell fate determination |
| Q27650906 | Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor |
| Q39580270 | Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal Mice |
| Q33671646 | Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma. |
| Q44777062 | Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes. |
| Q24685655 | Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle |
| Q33393564 | Stem cells, their niches and the systemic environment: an aging network |
| Q36498092 | Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression |
| Q41954511 | Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65 |
| Q33781802 | Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. |
| Q34163784 | Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification |
| Q36276365 | Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension |
| Q48223880 | Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease. |
| Q28613745 | Surfing the insulin signaling web |
| Q37595492 | Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes. |
| Q33636283 | Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). |
| Q37119783 | Systemically delivered insulin-like growth factor-I enhances mesenchymal stem cell-dependent fracture healing. |
| Q34104313 | TGF-beta signaling specifies axons during brain development |
| Q34943015 | TGF-β Inhibits Muscle Differentiation by Blocking Autocrine Signaling Pathways Initiated by IGF-II |
| Q33636784 | TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia |
| Q33853035 | Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model |
| Q35846814 | Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality |
| Q37372495 | Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice |
| Q38114062 | Targeted therapies in the treatment of advanced hepatocellular carcinoma |
| Q39776901 | Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers |
| Q33951057 | Targeting insulin-like growth factor axis in hepatocellular carcinoma |
| Q36383365 | Targeting insulin-like growth factor pathways. |
| Q27006846 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma |
| Q37778421 | Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance |
| Q92092123 | Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways |
| Q33817029 | The GH/IGF-1 axis in ageing and longevity |
| Q51766789 | The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
| Q24633774 | The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r |
| Q90716816 | The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth |
| Q41693140 | The IGF-I receptor and cancer |
| Q35747222 | The IGF-I regulatory system and its impact on skeletal and energy homeostasis |
| Q48507914 | The Impact of Aging on Cardio and Cerebrovascular Diseases. |
| Q90041392 | The Insulin/IGF System in Mammalian Sexual Development and Reproduction |
| Q36715210 | The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging |
| Q34548920 | The Role of GH and IGF-I in Mediating Anabolic Effects of Testosterone on Androgen-Responsive Muscle |
| Q64104414 | The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System |
| Q37681018 | The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche |
| Q28591965 | The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts |
| Q40278596 | The age of heterozygosity. |
| Q37343062 | The complete salmonid IGF-IR gene repertoire and its transcriptional response to disease |
| Q33619027 | The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity |
| Q36246110 | The conserved phosphoinositide 3-kinase pathway determines heart size in mice |
| Q37300974 | The cullin7 E3 ubiquitin ligase: a novel player in growth control |
| Q24554210 | The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor |
| Q41236736 | The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system |
| Q39096931 | The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma. |
| Q53100707 | The effects of IGF1 on the melanogenesis in alpaca melanocytes in vitro. |
| Q30440666 | The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization |
| Q28571907 | The effects of induced type-I diabetes on developmental regulation of insulin & insulin like growth factor-1 (IGF-1) receptors in the cerebellum of rat neonates |
| Q35147654 | The emerging role of insulin-like growth factors in testis development and function |
| Q93604101 | The evolution of concerted evolution |
| Q41934365 | The evolution of genomic imprinting via variance minimization: an evolutionary genetic model |
| Q33968784 | The evolution of genomic imprinting. |
| Q45305610 | The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific |
| Q28513514 | The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth |
| Q36934464 | The growth hormone-insulin-like growth factor-I axis in chronic kidney disease |
| Q34800544 | The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton |
| Q35451491 | The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function |
| Q37039560 | The hormonal action of IGF1 in postnatal mouse growth |
| Q36363332 | The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction |
| Q37323439 | The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis |
| Q39303151 | The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo |
| Q36929812 | The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists. |
| Q36438158 | The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs |
| Q36565586 | The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. |
| Q43241596 | The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. |
| Q37307864 | The insulin-like growth factor system and its receptors: A potential novel anticancer target |
| Q36892287 | The insulin-like growth factor system and the fetal brain: effects of poor maternal nutrition |
| Q40396511 | The insulin-like growth factor system as a target in breast cancer |
| Q36620533 | The insulin-like growth factor system in bone: basic and clinical implications |
| Q36468522 | The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities |
| Q33904081 | The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands |
| Q36006533 | The intersection between aging and cardiovascular disease |
| Q35551159 | The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes |
| Q35187561 | The link between the metabolic syndrome and cancer |
| Q24540613 | The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis |
| Q34074071 | The multi-functional role of insulin-like growth factor binding proteins in bone |
| Q34356918 | The myriad essential roles of microRNAs in cardiovascular homeostasis and disease |
| Q39576638 | The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin |
| Q34243964 | The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1). |
| Q41168866 | The response of motoneurons to neurotrophins |
| Q35690614 | The role and regulation of IGFBP-1 phosphorylation in fetal growth restriction |
| Q34592104 | The role of GH/IGF-I-mediated mechanisms in sex differences in cortical bone size in mice |
| Q35080570 | The role of circulating IGF-I: lessons from human and animal models |
| Q47373300 | The role of growth hormone in determining birth size and early postnatal growth, using congenital growth hormone deficiency (GHD) as a model |
| Q37608512 | The role of insulin-like growth factor during a postischemic period - new insights into pathophysiologic pathways in cardiac tissue |
| Q35135142 | The role of insulin-like growth factor-I in the physiopathology of hearing. |
| Q37381848 | The role of liver-derived insulin-like growth factor-I. |
| Q35588200 | The role of serum insulin-like growth factor I (IGF-I) in neonatal outcome. |
| Q48464009 | The role of the insulin-like growth factor I receptor in transformation and apoptosis |
| Q40374636 | The role of the insulin-like growth factor-I receptor in cancer |
| Q41301869 | The role of the insulin-like growth factors in the central nervous system |
| Q90045665 | The roles of glucagon-like peptide-2 and the intestinal epithelial insulin-like growth factor-1 receptor in regulating microvillus length |
| Q34392400 | The somatotropic axis and aging: mechanisms and persistent questions about practical implications |
| Q24812545 | The temporal requirements for insulin signaling during development in Drosophila. |
| Q36684355 | The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders. |
| Q35556180 | The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma |
| Q92642332 | Therapeutic Targeting of the IGF Axis |
| Q35069746 | Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling |
| Q37174878 | Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. |
| Q35080579 | Tissue-specific targeting of the insulin receptor gene |
| Q37329242 | Towards identification of molecular mechanisms of short stature |
| Q37678936 | Transcription factor ZBED6 mediates IGF2 gene expression by regulating promoter activity and DNA methylation in myoblasts. |
| Q36391637 | Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma |
| Q52180058 | Transcriptional regulation and biological significance of the insulin like growth factor II gene. |
| Q35082386 | Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation |
| Q41004106 | Transgenic animals: how they are made and their role in animal production and research |
| Q35553469 | Transplantation of Human Neural Progenitor Cells Expressing IGF-1 Enhances Retinal Ganglion Cell Survival |
| Q35087758 | Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice |
| Q37702186 | Type I insulin-like growth factor receptor signaling in hematological malignancies |
| Q37625883 | Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy. |
| Q24613053 | Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration |
| Q40373997 | Use of transgenics, null mutants, and antisense approaches to study ethanol's actions |
| Q35834090 | Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro |
| Q37707643 | Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength |
| Q28118453 | Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene |
| Q36433836 | Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival |
| Q33504202 | Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development |
| Q39726709 | beta-catenin mediates insulin-like growth factor-I actions to promote cyclin D1 mRNA expression, cell proliferation and survival in oligodendroglial cultures |
| Q46341145 | cDNA cloning, structural analysis, SNP detection and tissue expression profile of the IGF1 gene in Malabari and Attappady Black goats of India |
| Q37393361 | mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation |
| Q34341487 | mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis |
| Q37583421 | α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. |
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