The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis

scientific article

The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S10911-008-9097-1
P8608Fatcat IDrelease_bpbrbp4ea5gfljtun7nzu7bwzu
P698PubMed publication ID19002570

P2093author name stringRobert A Jones
Roger A Moorehead
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P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary glandQ34493249
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneQ34560337
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Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cellsQ35012773
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Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.Q36902961
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The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor numberQ42804213
IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transitionQ42826102
Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end budsQ43770402
Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasisQ44259982
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Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic miceQ45113758
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Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic miceQ74508495
Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pupsQ77897047
Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formationQ80213822
Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactationQ81002699
Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivationQ81165932
Expression of insulin-like growth factor-I receptor, estrogen receptor alpha, Bcl-2 and Bax proteins in human breast cancerQ81828284
P433issue4
P921main subjectoverexpressionQ61643320
P304page(s)407-413
P577publication date2008-11-11
P1433published inJournal of Mammary Gland Biology and NeoplasiaQ15724460
P1476titleThe impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis
P478volume13

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cites work (P2860)
Q34515619Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer
Q45093278Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer patients with diabetes
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Q34133760ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis
Q47143930Expression of insulin-like growth factor-1 receptor in circulating tumor cells of patients with breast cancer is associated with patient outcomes.
Q36251216Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats
Q34333651Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231
Q33916778IGF-I during primiparous pregnancy and maternal risk of breast cancer
Q34564798Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.
Q90570117Insulin-like growth factor-1 receptor (IGF-1R) expression on circulating tumor cells (CTCs) and metastatic breast cancer outcome: results from the TransMYME trial
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Q33707003Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells

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