The emerging role of insulin-like growth factors in testis development and function

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The emerging role of insulin-like growth factors in testis development and function is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1011848467
P356DOI10.1186/2051-4190-24-12
P932PMC publication ID4349729
P698PubMed publication ID25780585
P5875ResearchGate publication ID265139783

P2093author name stringRichard J Griffeth
Serge Nef
Vanessa Bianda
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Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testisQ33570650
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in miceQ33635803
Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implicationsQ33701918
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Activin stimulates Sertoli cell proliferation in a defined period of rat testis development.Q34297672
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Mediators of the Jak/STAT signaling pathway in human spermatozoaQ35780414
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IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cellsQ36660591
Effects of growth factors on testicular morphogenesisQ36812608
The hormonal action of IGF1 in postnatal mouse growthQ37039560
Phosphorylation of IRS proteins, insulin action, and insulin resistanceQ37252616
Sex determination and SRY: down to a wink and a nudge?Q37332508
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The game plan: cellular and molecular mechanisms of mammalian testis developmentQ37778485
Role of insulin-like growth factors in growth, development and feedingQ38083400
Minireview: nuclear insulin and insulin-like growth factor-1 receptors: a novel paradigm in signal transductionQ38090889
Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesisQ38931106
Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubulesQ38947824
Novel homozygous mutations in Desert hedgehog gene in patients with 46,XY complete gonadal dysgenesis and prediction of its structural and functional implications by computational methodsQ38962303
The insulin receptor and the molecular mechanism of insulin actionQ39527320
Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin.Q40185322
Physiological role of the insulin-like growth factor binding proteinsQ40548950
Insulin-like growth factor-binding protein-3 is partially responsible for high-serum-induced apoptosis in PC-3 prostate cancer cellsQ40913352
Glial cell line-derived neurotropic factor stimulates sertoli cell proliferation in the early postnatal period of rat testis developmentQ40937785
Proliferative activity of gonocytes, Sertoli cells and interstitial cells during testicular development in miceQ41166787
Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf miceQ41180092
IGF-I is required for normal embryonic growth in miceQ41510465
Short Stature Associated with a Novel Heterozygous Mutation in theInsulin-Like Growth Factor 1GeneQ41936501
In vitro regulation of pig Sertoli cell growth and function: effects of fibroblast growth factor and somatomedin-C.Q42512322
Effects of an Igf1 gene null mutation on mouse reproductionQ42523453
Autocrine regulation of insulin secretion in human ejaculated spermatozoa.Q42640868
Transforming growth factor-alpha stimulates proliferation of rat Sertoli cellsQ43690379
Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiationQ43972676
Follicle-stimulating hormone amplifies insulin-like growth factor I-mediated activation of AKT/protein kinase B signaling in immature rat Sertoli cellsQ44000632
Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cellsQ44576022
Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulationQ44636852
Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cellsQ44965362
Insulin and IR-beta in pig spermatozoa: a role of the hormone in the acquisition of fertilizing ability.Q45967229
Localization of insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) in equine testes.Q46027446
Molecular mechanisms of insulin-like growth factor-I mediated regulation of the steroidogenic acute regulatory protein in mouse leydig cellsQ46706007
Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse.Q47385300
Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.Q48000452
Insulin signal transduction through protein kinase cascadesQ48021735
Aging phenotype and its relationship with IGF-I gene promoter polymorphisms in elderly people living in Catalonia.Q50799078
Failure of normal adult Leydig cell development in androgen-receptor-deficient mice.Q52116471
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.Q52192889
Puberty occurring either spontaneously or induced precociously in rhesus monkey (Macaca mulatta) is associated with a marked proliferation of Sertoli cells.Q52201345
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Q52241373
Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.Q54420891
Thyroid hormone limits postnatal Sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice.Q54514573
Parental imprinting of the mouse insulin-like growth factor II gene.Q55052428
Insulin-like growth factors selectively stimulate spermatogonial, but not meiotic, deoxyribonucleic acid synthesis during rat spermatogenesisQ67575208
Thyroid hormone stimulates the production of insulin-like growth factor I (IGF-I) by immature rat Sertoli cellsQ68708110
Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical studyQ70049610
Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal developmentQ70377003
A role of insulin-like growth factor I for follicle-stimulating hormone receptor expression in rat granulosa cellsQ73372136
Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in miceQ74249450
Genetics of mouse growthQ77684683
Genetic evaluation of short statureQ83593767
P304page(s)12
P577publication date2014-08-18
P1433published inBasic and clinical andrologyQ27726097
P1476titleThe emerging role of insulin-like growth factors in testis development and function
P478volume24

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cites work (P2860)
Q47722771Cancer treatment in childhood and testicular function: the role of the somatic environment.
Q47599535Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review
Q48354260Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats
Q38521924Effects of psychological stress on male fertility
Q64098523Enhanced early-life nutrition upregulates cholesterol biosynthetic gene expression and Sertoli cell maturation in testes of pre-pubertal Holstein bulls
Q93265243Maternal undernutrition during pregnancy and lactation affects testicular morphology, the stages of spermatogenic cycle, and the testicular IGF-I system in adult offspring
Q33622769Polyunsaturated Fatty Acids in Male Ruminant Reproduction - A Review
Q91345042The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach
Q36191948Unravelling the genomic architecture of bull fertility in Holstein cattle
Q37207358Up-Regulation of microRNA-210 is Associated with Spermatogenesis by Targeting IGF2 in Male Infertility

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