Placental-specific IGF-II is a major modulator of placental and fetal growth.

scientific article

Placental-specific IGF-II is a major modulator of placental and fetal growth. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1053271634
P356DOI10.1038/NATURE00819
P698PubMed publication ID12087403

P50authorWolf ReikQ15994704
Anne Ferguson-SmithQ29949753
Gavin KelseyQ48304318
Wendy DeanQ60975980
Miguel ConstanciaQ61300816
P2093author name stringJennifer Hughes
Reinald Fundele
Abigail Fowden
Myriam Hemberger
Colin Sibley
Francesca Stewart
P2860cites workA family of insulin-like growth factor II mRNA-binding proteins represses translation in late developmentQ22008676
Genomic imprinting in mammalian development: a parental tug-of-warQ28278146
Disruption of imprinting caused by deletion of the H19 gene region in miceQ28287765
Genomic imprinting: parental influence on the genomeQ29616227
The long-term consequences of intra-uterine protein malnutrition for glucose metabolism.Q33798894
The uniqueness of the imprinting mechanismQ33885040
Fetal programming and adult healthQ34421315
Roles for genomic imprinting and the zygotic genome in placental development.Q35267816
Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethalityQ36731073
Phenotypic alterations in insulin-deficient mutant mice.Q36766264
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.Q36820044
Genomic imprinting of Mash2, a mouse gene required for trophoblast developmentQ38298288
Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr geneQ41415190
Physiological importance of system A-mediated amino acid transport to rat fetal developmentQ42514101
Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene MestQ48016474
Regulation of maternal behavior and offspring growth by paternally expressed Peg3.Q48243147
Imprinting and the epigenetic asymmetry between parental genomesQ48881402
The sins of the fathers and mothers: genomic imprinting in mammalian development.Q50532990
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.Q52164786
Discriminating translation of insulin-like growth factor-II (IGF-II) during mouse embryogenesis.Q52213178
Parental imprinting of the mouse insulin-like growth factor II gene.Q55052428
Synthesis of microporous transition-metal-oxide molecular sieves by a supramolecular templating mechanismQ59060757
Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: Effects of the Trophectoderm and Inner Cell Mass Genotypes in the Mouse1Q61963917
Neutral amino acid transport systems of microvillous membrane of human placentaQ68386314
Relative abundance and molecular size of immunoreactive insulin-like growth factors I and II in human fetal tissuesQ93511151
P433issue6892
P407language of work or nameEnglishQ1860
P921main subjectInsulin-like growth factor 2Q14874351
P304page(s)945-948
P577publication date2002-06-01
P1433published inNatureQ180445
P1476titlePlacental-specific IGF-II is a major modulator of placental and fetal growth
P478volume417

Reverse relations

cites work (P2860)
Q28570661A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells
Q36710170A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele
Q27023231A concise review on epigenetic regulation: insight into molecular mechanisms
Q41745799A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects
Q41601188A physiological, rather than a superovulated, post-implantation environment can attenuate the compromising effect of assisted reproductive techniques on gene expression in developing mice embryos.
Q38776096A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.
Q38968782A review of fundamental principles for animal models of DOHaD research: an Australian perspective.
Q64915661A systems perspective on placental amino acid transport.
Q34230567Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
Q47172119Adaptations in Maternofetal Calcium Transport in Relation to Placental Size and Fetal Sex in Mice
Q45992309Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice.
Q43233499Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.
Q34084829Addition of H19 'loss of methylation testing' for Beckwith-Wiedemann syndrome (BWS) increases the diagnostic yield.
Q27692668Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis
Q37633247Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms
Q37488229Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development
Q35913006Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia
Q33997325Altered gene expression in murine placentas in an infection-induced intrauterine growth restriction model: a microarray analysis.
Q34922904Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment
Q26766674Amniotic fluid: Source of trophic factors for the developing intestine
Q34236638An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.
Q35927951Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes
Q36268680Angiogenesis in implantation
Q91755110Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR
Q35563779Are major defects in children conceived in vitro due to innate problems in patients or to induced genetic damage?
Q37866974Are twins growth restricted?
Q36224444Association of SLC38A4 and system A with abnormal fetal birth weight
Q33817092Asymmetric paternal effect on offspring size linked to parent-of-origin expression of an insulin-like growth factor
Q55717962Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system.
Q54560423Bacterial infection promotes DNA hypermethylation.
Q38089794Beckwith-Wiedemann and Silver-Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth
Q59504115Biparental expression of ESX1L gene in placentas from normal and intrauterine growth-restricted pregnancies
Q36830264Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation.
Q33285306Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7.
Q35545821Cell death in the nervous system: lessons from insulin and insulin-like growth factors.
Q41904366Characterisation of the methylation pattern in the intragenic CpG island of the IGF2 gene in Bos taurus indicus cumulus cells during in vitro maturation
Q34882530Chromosome-wide identification of novel imprinted genes using microarrays and uniparental disomies.
Q55038818Coadaptation in mother and infant regulated by a paternally expressed imprinted gene.
Q47803343Colony-stimulating factor 2 acts from days 5 to 7 of development to modify programming of the bovine conceptus at day 86 of gestation†.
Q93097857Comparative Analysis of the Transcriptome and Proteome during Mouse Placental Development
Q92518096Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Q37635469Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features
Q36783148Could epigenetics play a role in the developmental origins of health and disease?
Q42288208Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
Q36567145Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: a new model of fetal growth restriction
Q90061344Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age
Q88090518DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins
Q36083008DNA Methylation Variation Trends during the Embryonic Development of Chicken
Q53220894DNA Methylation and Expression Patterns of Selected Genes in First-Trimester Placental Tissue from Pregnancies with Small-for-Gestational-Age Infants at Birth.
Q92499397DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2-DMR0 as a DNA methylation-dependent, P0 promoter-specific enhancer
Q36521372DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
Q36383223DNA methylation in the human placenta and fetal growth (review).
Q35754822DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.
Q36427198DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults
Q37285300Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis
Q53625137Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin-like growth factor-II deficient conceptuses (Igf2m+/p-).
Q28507386Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality
Q36149236Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements
Q35810061Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy.
Q36124326Development of structures and transport functions in the mouse placenta
Q35899003Developmental plasticity of the microscopic placental architecture in relation to litter size variation in the common marmoset monkey (Callithrix jacchus).
Q27315822Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup
Q57230563Dietary composition programmes placental phenotype in mice
Q47701588Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation
Q34557200Differential gene expression in the endometrium on gestation day 12 provides insight into sow prolificacy.
Q50115059Differential methylation of insulin-like growth factor 2 in offspring of physically active pregnant women
Q46148910Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.
Q90279933Disruption of the Igf2 gene alters hepatic lipid homeostasis and gene expression in the newborn mouse
Q61847026Distinct expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta
Q47980257Divergent genetic and epigenetic post-zygotic isolation mechanisms in Mus and Peromyscus.
Q37585136Does intrauterine injection of low-molecular-weight heparin improve the clinical pregnancy rate in intracytoplasmic sperm injection?
Q37593992Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon.
Q80134195Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet
Q34994085Dynamic expression of imprinted genes associates with maternally controlled nutrient allocation during maize endosperm development.
Q37264901EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver-Russell and Beckwith-Wiedemann syndrome.
Q30387485Early developmental conditioning of later health and disease: physiology or pathophysiology?
Q52025737Effect of culturing mouse embryos under different oxygen concentrations on subsequent fetal and placental development.
Q36121643Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction
Q28279818Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight
Q36495097Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction
Q35655232Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia
Q35608806Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial.
Q38626695Epigenesis and plasticity of mouse trophoblast stem cells
Q28730353Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight
Q39029575Epigenetic control of β-cell function and failure
Q33784575Epigenetic disorders and altered gene expression after use of Assisted Reproductive Technologies in domestic cattle.
Q36311154Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.
Q35558450Epigenetic modifications of the immune system in health and disease
Q35666404Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma.
Q38205048Epigenetic regulation of the Igf2/H19 gene cluster
Q37781197Epigenetic reprogramming of host genes in viral and microbial pathogenesis
Q37981128Epigenetics and developmental programming of adult onset diseases
Q37801493Epigenetics and the placenta
Q41689688Epigenetics in formation, function, and failure of the endocrine pancreas
Q92480938Establishment of human trophoblast stem cells from human induced pluripotent stem cell-derived cystic cells under micromesh culture
Q33735829Evaluation of allelic expression of imprinted genes in adult human blood.
Q92542129Evidence of adaptation of maternofetal transport of glutamine relative to placental size in normal mice, and in those with fetal growth restriction
Q36778250Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.
Q36762442Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3
Q46538872Evolution and Function of the Insulin and Insulin-like Signaling Network in Ectothermic Reptiles: Some Answers and More Questions
Q36001906Exposure and fetal growth-associated miRNA alterations in the human placenta
Q44762564Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2.
Q37713031Exposure of pregnant mice to triclosan impairs placental development and nutrient transport
Q33320359Expression and protein localisation of IGF2 in the marsupial placenta
Q36089302Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients
Q50641665Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA transport in mouse trophoblasts.
Q37709914Fetal and maternal hemodynamics in pregnancy: new insights in the cardiovascular adaptation to uncomplicated pregnancy, twin-to-twin transfusion syndrome and congenital diaphragmatic hernia
Q83231244Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice
Q64062127Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy
Q35871434Fetal signaling through placental structure and endocrine function: illustrations and implications from a nonhuman primate model
Q35813932From Pre-Clinical Studies to Clinical Trials: Generation of Novel Therapies for Pregnancy Complications
Q37556602Functional expression study of igf2 antisense transcript in mouse
Q48395191Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice
Q97681127Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency
Q27312725Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting
Q48253236Gene expression and epigenetic aberrations in F1-placentas fathered by obese males.
Q38332825Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction.
Q36448002Genetic variations and normal fetal growth.
Q91596236Genomic imprinting and its effects on postnatal growth and adult metabolism
Q37769333Genomic imprinting and mammalian reproduction.
Q37715275Genomic imprinting in development, growth, behavior and stem cells
Q36436530Genomic imprinting in the placenta
Q36421141Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Q85068250Genomic imprinting status of IGF-II and H19 in placentas of fetal growth restriction patients
Q33550774Genotype-temperature interaction in the regulation of development, growth, and morphometrics in wild-type, and growth-hormone transgenic coho salmon.
Q35561940Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation.
Q33951993Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
Q37081982Granulocyte-macrophage colony stimulating factor (GM-CSF) enhances cumulus cell expansion in bovine oocytes
Q26852243Growth factors, nutrient signaling, and cardiovascular aging
Q35031144H19 and Igf2--enhancing the confusion?
Q36741014HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy
Q37992688Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success
Q39034561Hepatitis B virus X protein promotes P3 transcript expression of the insulin-like growth factor 2 gene via inducing hypomethylation of P3 promoter in hepatocellular carcinoma
Q37061691High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice
Q49163873Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.
Q51792341Hormones as epigenetic signals in developmental programming.
Q39366665How nutrition and the maternal microbiota shape the neonatal immune system.
Q34348245Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs
Q37305034Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes
Q35849360Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.
Q24816630Hypoxia-activated genes from early placenta are elevated in preeclampsia, but not in Intra-Uterine Growth Retardation
Q34594074IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor
Q36471719IGF2/H19 hypomethylation is tissue, cell, and CpG site dependent and not correlated with body asymmetry in adolescents with Silver-Russell syndrome
Q36561897IGF2: epigenetic regulation and role in development and disease
Q33660062IGFBP-4 regulates adult skeletal growth in a sex-specific manner
Q24535664Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2
Q46259020Identification and expression analysis of cDNA encoding insulin-like growth factor 2 in horses.
Q34973526Identification of maternally regulated fetal gene networks in the placenta with a novel embryo transfer system in mice.
Q38807060Immunoexpression of IGF1, IGF2, and osteopontin in craniofacial bone repair associated with autogenous grafting in rat models treated with alendronate sodium.
Q36296120Impact of body mass index on breast cancer in accordance with the life-stage of women
Q36049859Impaired placental nutrient transport in mice generated by in vitro fertilization
Q28585563Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
Q26998591Imprinted and X-linked non-coding RNAs as potential regulators of human placental function
Q28306944Imprinted genes, placental development and fetal growth
Q45957876Imprinting Status of IGF2 in Cord Blood Cells of Han Chinese Newborns.
Q42738682Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta
Q35043723Imprinting and disease
Q37543706Imprinting and extraembryonic tissues-mom takes control
Q48096674Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.
Q34201168In vitro assessment of mouse fetal abdominal aortic vascular function
Q35931177In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm
Q43469814Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia
Q34572315Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations
Q54745902Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells
Q38514079Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta
Q51837006Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea.
Q28564485Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats
Q87475372Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses
Q38866974Insulin-like signaling (IIS) responses to temperature, genetic background, and growth variation in garter snakes with divergent life histories
Q36974996Intrauterine Growth Restriction: Hungry for an Answer
Q35174309Isoforms of amino acid transporters in placental syncytiotrophoblast: plasma membrane localization and potential role in maternal/fetal transport
Q33638375Karyotype characterization of in vivo- and in vitro-derived porcine parthenogenetic cell lines
Q34996680Kiss1 mutant placentas show normal structure and function in the mouse
Q42618270Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1.
Q37106900L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth
Q61845341Low maternal concentrations of soluble vascular endothelial growth factor receptor-2 in preeclampsia and small for gestational age
Q81502930Low maternal serum levels of pregnancy-associated plasma protein-A during the first trimester are associated with subsequent preterm delivery with preterm premature rupture of membranes
Q60539339Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
Q51976586Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development.
Q40016345Maternal BMI, gestational diabetes, and weight gain in relation to childhood obesity: The mediation effect of placental weight
Q47806592Maternal Fenvalerate Exposure Induces Fetal Intrauterine Growth Restriction Through Disrupting Placental Thyroid Hormone Receptor Signaling
Q33870606Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
Q45103962Maternal administration of the herbal medicine toki-shakuyaku-san promotes fetal growth and placental gene expression in normal mice
Q37323055Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation
Q90350899Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner
Q92377119Maternal control of suspensor programmed cell death via gibberellin signaling
Q89313055Maternal exercise in rats upregulates the placental insulin-like growth factor system with diet- and sex-specific responses: minimal effects in mothers born growth restricted
Q33511008Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring
Q38692978Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?
Q38692642Maternal placenta modulates a deleterious fetal mutation
Q37016791Maternal protein restriction regulates IGF2 system in placental labyrinth
Q33789139Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study
Q34774561Maternal-fetal conflict--lessons from a transgene
Q35065101Maternal-placental-fetal interactions in the endocrine regulation of fetal growth: role of somatotrophic axes.
Q47172204Maternally-inherited Grb10 reduces placental size and efficiency
Q59791409Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction
Q58777315Melatonin Increases Fetal Weight in Wild-Type Mice but Not in Mouse Models of Fetal Growth Restriction
Q50640391Methylation analysis of the intergenic differentially methylated region of DLK1-GTL2 in human.
Q48691224Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies
Q39479350MiR-483-5p controls angiogenesis in vitro and targets serum response factor
Q47113848MiR-483-5p promotes IGF-II transcription and is associated with poor prognosis of hepatocellular carcinoma
Q91673977Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children
Q36455952Modes of imprinted gene action in learning disability
Q57273797Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
Q49112560Molecular and clinical findings and their correlations in Silver-Russell syndrome: implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas.
Q36316644More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain.
Q47357067Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro
Q35130565Non-random, individual-specific methylation profiles are present at the sixth CTCF binding site in the human H19/IGF2 imprinting control region
Q33629101Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.
Q34483901Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia
Q90701664Offspring genetic effects on maternal care
Q37261690Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences
Q51408251Opposite risk patterns for autism and schizophrenia are associated with normal variation in birth size: phenotypic support for hypothesized diametric gene-dosage effects.
Q57230571Origin and characteristics of glycogen cells in the developing murine placenta
Q35737547Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development
Q28591355Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction
Q47951370Paternal allele of IGF2 gene haplotype CTG is associated with fetal and placental growth in Japanese
Q43763890Paternal breed effects on expression of IGF-II, BAK1 and BCL2-L1 in bovine preimplantation embryos
Q45784670Paternal contribution to small for gestational age babies: a multicenter prospective study
Q37484070Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight
Q37018192Pathogenesis of infantile haemangioma: new molecular and cellular insights
Q36996530Pathological interactions with the timing of birth and uterine activation.
Q24293081Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein
Q33271303Physical mapping of the IGF2 locus in the South American opossum Monodelphis domestica
Q59030457Piece of cake
Q42599702Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis
Q37323034Placenta plays a critical role in maternal-fetal resource allocation
Q36214670Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth
Q26768156Placental Adaptation: What Can We Learn from Birthweight:Placental Weight Ratio?
Q28384560Placental DNA hypomethylation in association with particulate air pollution in early life
Q92313951Placental Delta-Like 1 Gene DNA Methylation Levels Are Related to Mothers' Blood Glucose Concentration
Q30245567Placental Origins of Chronic Disease
Q104288192Placental adaptations in a nonhuman primate model of gestational protein restriction
Q35003807Placental adaptations in growth restriction
Q36929799Placental dysfunction and fetal programming: the importance of placental size, shape, histopathology, and molecular composition
Q40372155Placental dysfunction is associated with altered microRNA expression in pregnant women with low folate status
Q90619607Placental genotype affects early postpartum maternal behaviour
Q36114020Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice
Q36414579Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations
Q36502314Placental insulin-like growth factor II (IGF-II) and its relation to litter size in the common marmoset monkey (Callithrix jacchus).
Q35542826Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia
Q46034929Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia.
Q36215979Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study
Q38880458Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.
Q47844221Placental programming of anxiety in adulthood revealed by Igf2-null models.
Q37832610Placental regulation of peptide hormone and growth factor activity by proMBP.
Q34540469Placental transport in response to altered maternal nutrition
Q51320374Placental-Specific Overexpression of sFlt-1 Alters Trophoblast Differentiation and Nutrient Transporter Expression in an IUGR Mouse Model.
Q33734866Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.
Q34332616Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta
Q34585683Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport
Q45347972Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth.
Q28655490Post-natal imprinting: evidence from marsupials
Q61445391Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming
Q37131377Predisposing Factors to Abnormal First Trimester Placentation and the Impact on Fetal Outcomes
Q50701948Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.
Q34401375Prenatal caloric restriction enhances DNA methylation and MeCP2 recruitment with reduced murine placental glucose transporter isoform 3 expression
Q40471730Prenatal diet and childhood ADHD: exploring the potential role of IGF2 methylation.
Q64053408Prenatal epigenetics diets play protective roles against environmental pollution
Q33818299Prenatal stress programming of offspring feeding behavior and energy balance begins early in pregnancy
Q37510548Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems
Q38555881Prevention - Passive smoking and pregnancy
Q36378618Programming placental nutrient transport capacity.
Q34358824Promoter-specific expression and imprint status of marsupial IGF2
Q34445469Promoter-specific expression of the imprinted IGF2 gene in cattle (Bos taurus).
Q54591187Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer.
Q34507316Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity
Q34412090Re-expression of IGF-II is important for beta cell regeneration in adult mice
Q50582951Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta.
Q59328860Reduced Uteroplacental Perfusion Pressure (RUPP) causes altered trophoblast differentiation and pericyte reduction in the mouse placenta labyrinth
Q57490801Regulation of Placental Development and Its Impact on Fetal Growth-New Insights From Mouse Models
Q36470340Regulation of nutrient transport across the placenta.
Q36734567Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.
Q35058363Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.
Q52085968Resourceful imprinting.
Q37317744Review paper: a review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice.
Q40337404Role and mechanism of insulin-like growth factor 2 on the proliferation of human trophoblasts in vitro
Q38731327Role of hypoxia during nephrogenesis.
Q24534366Role of pro-IGF-II processing by proprotein convertase 4 in human placental development
Q34733310Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
Q47247208Searching for genomic variants in IGF2 and CDKN1C in Silver-Russell syndrome patients
Q46463604Serine protease HtrA1 is developmentally regulated in trophoblast and uterine decidual cells during placental formation in the mouse
Q35035567Sildenafil citrate increases fetal weight in a mouse model of fetal growth restriction with a normal vascular phenotype.
Q36303236Silver nanoparticles cause complications in pregnant mice
Q21202882Silver-Russell syndrome: genetic basis and molecular genetic testing
Q52618444Similarity and Variation in the Insulin-like Growth Factor 2 - H19 Locus in Primates.
Q59132940Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice
Q28507493Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice
Q34763832Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation.
Q37214686Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory distress
Q36076512Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women
Q48764255Superovulation alters the expression of imprinted genes in the midgestation mouse placenta
Q38582631The 'Developmental Origins' Hypothesis: relevance to the obstetrician and gynecologist
Q38634060The Consequences of Maternal-Embryonic Cross Talk During the Periconception Period on Subsequent Embryonic Development.
Q37064809The IGF axis and placental function. a mini review
Q44216514The IGF-II-deficient placenta: aspects of its function
Q90041392The Insulin/IGF System in Mammalian Sexual Development and Reproduction
Q57043124The Regulatory Effects of Brown Adipose Tissue Thermogenesis on Maternal Metabolic Adaptation, Placental Efficiency, and Fetal Growth in Mice
Q92852980The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
Q47752006The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.
Q37154349The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane
Q50026513The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.
Q35037064The biology of preeclampsia
Q48090298The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA.
Q90631104The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy
Q50134100The complex genetics of human insulin-like growth factor 2 are not reflected in public databases
Q35147654The emerging role of insulin-like growth factors in testis development and function
Q26853148The epigenetic lorax: gene-environment interactions in human health
Q46727605The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Q38779863The evolving landscape of imprinted genes in humans and mice: Conflict among alleles, genes, tissues, and kin.
Q35177399The genetics of pre-eclampsia: a feto-placental or maternal problem?
Q43489034The human insulin superfamily of polypeptide hormones
Q36363332The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction
Q34138734The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes
Q33628787The importance of imprinting in the human placenta.
Q43093150The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat.
Q93103675The insulin-like growth factor 2 gene in mammals: Organizational complexity within a conserved locus
Q37278762The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region
Q26795427The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy
Q37284688The placental imprintome and imprinted gene function in the trophoblast glycogen cell lineage
Q38046263The risk of maternal obesity to the long-term health of the offspring
Q34426232The role of genomic imprinting in biology and disease: an expanding view
Q37733830The role of imprinted genes in mediating susceptibility to neuropsychiatric disorders.
Q36253110The role of insulin-like growth factor binding proteins in development
Q27008068The role of placental nutrient sensing in maternal-fetal resource allocation
Q90295602The significance of the placental genome and methylome in fetal and maternal health
Q63407340The use of mouse models to explore fetal–maternal interactions underlying pre-eclampsia
Q37274079Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta
Q91474110Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics
Q33552791Time from pre-eclampsia diagnosis to delivery affects future health prospects of children
Q41900211Tissue-specific DNA methylation profiles in newborns
Q43479895Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model
Q52101088Transgene instability in mice injected with an in vitro methylated Igf2 gene.
Q46243350Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans
Q33917113Treating the dysfunctional placenta
Q37056248Tumor-homing peptides as tools for targeted delivery of payloads to the placenta.
Q37702186Type I insulin-like growth factor receptor signaling in hematological malignancies
Q47605186Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestation
Q37471093Understanding placental nutrient transfer--why bother? New biomarkers of fetal growth
Q38341397Urine proteomic studies in preeclampsia
Q39436334Variation in sequences and mRNA expression levels of growth hormone (GH), insulin-like growth factor I (IGF-I) and II (IGF-II) genes between prolific Lezhi black goat and non-prolific Tibetan goat (Capra hircus).
Q36227122Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites
Q28389751Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta
Q30440507Viral infection, inflammation and schizophrenia
Q38246516What does genetics tell us about imprinting and the placenta connection?
Q33338342What good is genomic imprinting: the function of parent-specific gene expression
Q42919552Wolf Reik: Inheritance beyond DNA. Interview by Nicole Lebrasseur
Q36621894mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
Q91640787miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta

Search more.