| scholarly article | Q13442814 |
| P50 | author | Humphrey H-C Yao | Q59689712 |
| Blanche Capel | Q68707674 | ||
| P2093 | author name string | Wendy Whoriskey | |
| P2860 | cites work | Spatial and temporal patterns of cell division during early Xenopus embryogenesis. | Q52142085 |
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| Migration of mesonephric cells into the mammalian gonad depends on Sry. | Q52174735 | ||
| Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. | Q52176603 | ||
| Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. | Q52536184 | ||
| Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development | Q71864560 | ||
| Limb bud mesenchyme permits seminiferous cord formation in the mouse fetal testis but subsequent testosterone output is markedly affected by the sex of the donor stromal tissue | Q72237710 | ||
| Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells | Q72270548 | ||
| Mesonephric contribution to testis differentiation in the fetal mouse | Q72563302 | ||
| The role of the mesonephros in cell differentiation and morphogenesis of the mouse fetal testis | Q72734545 | ||
| Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes | Q72929881 | ||
| Sry induces cell proliferation in the mouse gonad | Q73400626 | ||
| Studies on the onset of Leydig precursor cell differentiation in the prepubertal rat testis | Q73907374 | ||
| Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis | Q74756238 | ||
| Mesonephric stromal cells differentiate into Leydig cells in the mouse fetal testis | Q77403615 | ||
| Characterization of two patched receptors for the vertebrate hedgehog protein family | Q22007983 | ||
| A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy | Q24534642 | ||
| Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine | Q28138510 | ||
| Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis | Q28202975 | ||
| Female development in mammals is regulated by Wnt-4 signalling | Q28507770 | ||
| Altered neural cell fates and medulloblastoma in mouse patched mutants | Q28588056 | ||
| Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation | Q29617905 | ||
| A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes | Q29618455 | ||
| HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo | Q29618704 | ||
| Expression of a Delta homologue in prospective neurons in the chick | Q29619573 | ||
| Apoptosis and morphology in mouse embryos by confocal laser scanning microscopy | Q30775069 | ||
| Confocal laser scanning microscopy of apoptosis in organogenesis-stage mouse embryos | Q31971798 | ||
| Formation of morphogen gradients in the Drosophila wing | Q33707737 | ||
| hedgehog and wing development in Drosophila: a morphogen at work? | Q33910582 | ||
| Origin, differentiation and regulation of fetal and adult Leydig cells | Q34289976 | ||
| Sertoli cell signaling by Desert hedgehog regulates the male germline | Q34396888 | ||
| In situ analysis of fetal, prepuberal and adult XX—XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY | Q34581828 | ||
| Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor. | Q38293129 | ||
| Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1. | Q38355685 | ||
| Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules | Q38947824 | ||
| A developmental study of the Desert hedgehog-null mouse testis | Q39355851 | ||
| Sonic hedgehog: making the gradient | Q41112826 | ||
| Morphogens and pattern formation | Q41572127 | ||
| Paracrine-mediated apoptosis in reproductive tract development. | Q41613157 | ||
| Generating green fluorescent mice by germline transmission of green fluorescent ES cells | Q42819708 | ||
| Cholesterol side-chain cleavage activity in rat fetal gonads: a limiting step for ovarian steroidogenesis | Q43577347 | ||
| Male development of chromosomally female mice transgenic for Sry. | Q44051365 | ||
| Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog | Q48194137 | ||
| Sertoli cells of the mouse testis originate from the coelomic epithelium. | Q50858287 | ||
| Male-specific cell migration into the developing gonad. | Q50921659 | ||
| Characterization of mesonephric cells that migrate into the XY gonad during testis differentiation. | Q52133353 | ||
| P433 | issue | 11 | |
| P921 | main subject | Leydig cell differentiation | Q14905204 |
| Desert hedgehog | Q21979936 | ||
| P304 | page(s) | 1433-1440 | |
| P577 | publication date | 2002-06-01 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis | |
| P478 | volume | 16 |
| Q35813212 | 46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome Sequencing |
| Q39605424 | A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis |
| Q52646455 | A highlight on Sonic hedgehog pathway. |
| Q36732493 | A review of hedgehog signaling in cranial bone development |
| Q34098937 | Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish |
| Q39118695 | Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling |
| Q31037096 | Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice |
| Q37171162 | Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism |
| Q37692468 | All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched |
| Q33635803 | An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice |
| Q37187812 | Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice |
| Q37354024 | Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility |
| Q34808361 | Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells |
| Q88712234 | At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad |
| Q36553191 | Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem |
| Q36103926 | Building pathways for ovary organogenesis in the mouse embryo |
| Q24594830 | Building the mammalian testis: origins, differentiation, and assembly of the component cell populations |
| Q54959590 | Canonical Sonic Hedgehog Signaling in Early Lung Development. |
| Q35705481 | Cell biology of Leydig cells in the testis |
| Q35627209 | Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells |
| Q26826925 | Cell fate commitment during mammalian sex determination |
| Q38808601 | Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation. |
| Q33795395 | Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta |
| Q35617475 | Cellular microenvironment dictates androgen production by murine fetal Leydig cells in primary culture |
| Q46934335 | Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate |
| Q35746932 | Chromosome y regulates survival following murine coxsackievirus b3 infection |
| Q35435972 | Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes |
| Q90151867 | Comparative and evolutionary analysis of the reptilian hedgehog gene family (Shh, Dhh, and Ihh) |
| Q37135554 | Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice |
| Q46885327 | Cyclopamine did not affect mouse oocyte maturation in vitro but decreased early embryonic development |
| Q34088433 | Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial |
| Q90679479 | Development of fetal and adult Leydig cells |
| Q38770634 | Development, function and fate of fetal Leydig cells |
| Q34760230 | Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation. |
| Q90573469 | Directing differentiation of human induced pluripotent stem cells toward androgen-producing Leydig cells rather than adrenal cells |
| Q28202975 | Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis |
| Q36103896 | Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs |
| Q30412124 | Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice |
| Q64445565 | Effect of environmental and pharmaceutical exposures on fetal testis development and function: a systematic review of human experimental data |
| Q36812608 | Effects of growth factors on testicular morphogenesis |
| Q46250072 | Effects of the insulin-like growth factor system on testicular differentiation and function: a review of the literature |
| Q28513287 | Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development |
| Q54117942 | Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control. |
| Q47097661 | Endocrine disrupting compounds exposure and testis development in mammals |
| Q30436065 | Epithelial-mesenchymal crosstalk in Wolffian duct and fetal testis cord development |
| Q34789845 | Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates |
| Q33585208 | Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation |
| Q61507019 | Expression of hedgehog signalling components in adult mouse testis |
| Q48137242 | Expression profiles of Sox transcription factors within the postnatal rodent testes |
| Q38867291 | Expressions of Sox9, Sox5, and Sox13 transcription factors in mice testis during postnatal development. |
| Q26825689 | FOXL2: a central transcription factor of the ovary |
| Q33615109 | Fetal Leydig cell origin and development |
| Q36093121 | Fetal Leydig cells: progenitor cell maintenance and differentiation |
| Q21092773 | Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination |
| Q50459159 | From the Cover: Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice. |
| Q90281950 | Functional analysis of novel desert hedgehog gene variants improves the clinical interpretation of genomic data and provides a more accurate diagnosis for patients with 46,XY differences of sex development |
| Q36326023 | GATA-4 is required for sex steroidogenic cell development in the fetal mouse |
| Q28511744 | GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development |
| Q28586188 | GPR56 is essential for testis development and male fertility in mice |
| Q36844194 | Gender differences in neurodevelopment and epigenetics. |
| Q38049482 | Gene mutations associated with anomalies of human gonad formation |
| Q28274799 | Genetic control of testis development |
| Q35668796 | Genetic mechanisms that regulate testis determination |
| Q38253305 | Genetic regulation of mammalian gonad development. |
| Q100418580 | Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks |
| Q46875102 | Global gene expression during early differentiation of Xenopus (Silurana) tropicalis gonad tissues |
| Q36445161 | Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice |
| Q37427953 | Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma |
| Q59792326 | Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells |
| Q36923126 | Hedgehog in the Drosophila testis niche: what does it do there? |
| Q36444127 | Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis |
| Q55052456 | Hedgehog signaling: endocrine gland development and function. |
| Q35519207 | Hedgehog signalling promotes germ cell survival in the rat testis |
| Q33864161 | Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells. |
| Q46113959 | Hepatocyte growth factor is a mouse fetal Leydig cell terminal differentiation factor. |
| Q26829353 | How to make a gonad: cellular mechanisms governing formation of the testes and ovaries |
| Q33766403 | Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system |
| Q46238829 | Identification of Sertoli cell-specific transcripts in the mouse testis and the role of FSH and androgen in the control of Sertoli cell activity |
| Q47146650 | Identification of genome-wide SNP-SNP interactions associated with important traits in chicken. |
| Q57294445 | In Vitro functional characterization of the novel DHH mutations p.(Asn337Lysfs*24) and p.(Glu212Lys) associated with gonadal dysgenesis |
| Q37305066 | In search of adrenocortical stem and progenitor cells |
| Q59805358 | In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development |
| Q38934585 | In vitro and molecular modeling analysis of two mutant desert hedgehog proteins associated with 46,XY gonadal dysgenesis. |
| Q24620091 | Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis |
| Q33843277 | Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
| Q57280068 | Journée scientifique de la SALF : le testicule en devenir |
| Q37691705 | LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. |
| Q33503210 | Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination |
| Q36833409 | Male reprotoxicity and endocrine disruption |
| Q24633383 | Male sex determination: insights into molecular mechanisms |
| Q27691819 | Mammalian sex determination—insights from humans and mice |
| Q42377390 | Mapping lineage progression of somatic progenitor cells in the mouse fetal testis |
| Q36395064 | Mechanisms of Disease: normal and abnormal gonadal development and sex determination in mammals. |
| Q38853372 | Mesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development |
| Q52055129 | Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. |
| Q38864915 | Methods for the Study of Gonadal Development |
| Q37700522 | Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm. |
| Q33637467 | Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease |
| Q91807294 | Molecular Characterization of XX Maleness |
| Q35769881 | Molecular and genetic regulation of testis descent and external genitalia development |
| Q37949273 | Molecular mechanisms of sexual development |
| Q38366001 | Morphological and functional maturation of Leydig cells: from rodent models to primates |
| Q34541816 | Mouse testis development and function are differently regulated by follicle-stimulating hormone receptors signaling during fetal and prepubertal life |
| Q36391570 | Neuroendocrine regulation of Leydig cell development |
| Q36842267 | Notch signaling maintains Leydig progenitor cells in the mouse testis |
| Q35813860 | One tissue, two fates: molecular genetic events that underlie testis versus ovary development |
| Q38864879 | Origin and Differentiation of Androgen-Producing Cells in the Gonads |
| Q38472644 | Origin and function of embryonic Sertoli cells |
| Q48510887 | Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update |
| Q47879454 | Overactivation of hedgehog signaling in the developing Müllerian duct interferes with duct regression in males and causes subfertility |
| Q44748964 | Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner |
| Q28278828 | Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment |
| Q28594102 | Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad |
| Q37695304 | Pleiotropic Activities of HGF/c-Met System in Testicular Physiology: Paracrine and Endocrine Implications. |
| Q28595065 | Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice |
| Q52604589 | Primordial germ cell proliferation is impaired in Fused Toes mutant embryos |
| Q42151708 | Progenitor cells of the testosterone-producing Leydig cells revealed |
| Q42776470 | Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells |
| Q27320956 | Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos |
| Q36072093 | Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells |
| Q52099709 | Regionally distinct potencies of mouse XY genital ridge to initiate testis differentiation dependent on anteroposterior axis. |
| Q44613101 | Regulation of Sertoli Cell Number and Activity by Follicle-Stimulating Hormone and Androgen during Postnatal Development in the Mouse |
| Q34517964 | Regulation of male sex determination: genital ridge formation and Sry activation in mice |
| Q52691473 | Regulation of masculinization: androgen signalling for external genitalia development. |
| Q36684657 | Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes |
| Q91768365 | Relationship of transcriptional markers to Leydig cell number in the mouse testis |
| Q88774823 | Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh |
| Q38177814 | Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation. |
| Q28595071 | Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis |
| Q39001393 | SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice |
| Q36897836 | SRY and the standoff in sex determination |
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| Q36236310 | Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development |
| Q33570650 | Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis |
| Q26864229 | Sex and hedgehog: roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation |
| Q52099274 | Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. |
| Q52108403 | Sexually dimorphic gene expression in the developing mouse gonad. |
| Q35674942 | Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice. |
| Q42757144 | Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung |
| Q58772646 | Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool |
| Q38088823 | Smoothened antagonists: a promising new class of antitumor agents |
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| Q38044171 | Steroid hormones and the development of reproductive organs |
| Q30356184 | Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice |
| Q30426191 | Steroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineage |
| Q36303516 | Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells |
| Q44640928 | Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. |
| Q46093008 | Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia |
| Q26764892 | Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors |
| Q47133127 | Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. |
| Q34539857 | Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals |
| Q38705259 | Testis Cord Maintenance in Mouse Embryos: Genes and Signaling. |
| Q38116931 | Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis |
| Q33581585 | Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. |
| Q57470603 | The adult human testis transcriptional cell atlas |
| Q35147654 | The emerging role of insulin-like growth factors in testis development and function |
| Q36391041 | The foetal Leydig cell-- differentiation, function and regulation |
| Q33815438 | The road to maleness: from testis to Wolffian duct. |
| Q35046896 | The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia |
| Q28584889 | The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression |
| Q34446269 | The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells. |
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| Q38626969 | Vertebrate sex determination: evolutionary plasticity of a fundamental switch. |
| Q43125848 | Where do adult Leydig cells come from? |
| Q28513410 | Wnt4 is required for proper male as well as female sexual development |
| Q50627400 | Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis. |
| Q28585638 | Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis |
| Q38942007 | Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice |
| Q38336103 | XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. |
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