Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma

scientific article published on 22 October 2016

Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7150/JCA.15786
P932PMC publication ID5118670
P698PubMed publication ID27877222

P2093author name stringPing Li
Gang Jin
Weimin Hu
Zhaoshen Li
Zhiping Wang
Jun Gao
Yuqiong Wang
Hongyu Wu
Xiangyu Kong
Shude Li
Quanjiang Li
P2860cites workGli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleusQ37465396
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.Q37482716
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinomaQ37497757
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Nonclassical hedgehog-GLI signaling and its clinical implicationsQ38127609
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Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancerQ40254051
Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancerQ40257960
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Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.Q51056982
Pancreatic CancerQ54135367
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceQ61776577
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationQ24600279
Inflammation and cancerQ24649640
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Mutations affecting segment number and polarity in DrosophilaQ28273492
Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesisQ28505923
Combined activities of hedgehog signaling inhibitors regulate pancreas developmentQ28510309
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochordQ28566360
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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisQ29614405
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarityQ29616632
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryosQ34346998
Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesisQ34399827
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myelomaQ36474588
Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesisQ36516948
Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibitionQ36796814
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapyQ36921866
Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma.Q37337163
P433issue14
P921main subjectadenocarcinomaQ356033
P304page(s)2067-2076
P577publication date2016-10-22
P1433published inJournal of CancerQ6294901
P1476titleHedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma
P478volume7

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cites work (P2860)
Q42657219GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment
Q64245029Gli Proteins: Regulation in Development and Cancer
Q92263331Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
Q64226364Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity
Q58692807Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
Q58758006Role of canonical Hedgehog signaling pathway in liver
Q92924437Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments
Q53691500Targeting GLI Transcription Factors in Cancer.
Q64243451Targeting the Hedgehog Pathway in Cancer: Current Evidence and Future Perspectives
Q58091111Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus

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