Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

scientific article

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-07-368142
P932PMC publication ID3525024
P698PubMed publication ID22821765

P50authorKenneth C. AndersonQ28421846
Katia TodoertiQ39052018
Aldo M RoccaroQ40001639
Antonino NeriQ56850455
Marco RossiQ57067930
Teresa CalimeriQ58032684
Stefano MolicaQ59660152
Fortunato MorabitoQ90396313
Pierfrancesco TassoneQ100766165
P2093author name stringNikhil C Munshi
Abdel Kareem Azab
Constantine S Mitsiades
Simona Blotta
Nicola Amodio
Umberto Foresta
Jana Jakubikova
Piersandro Tagliaferri
P2860cites workCommon molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancerQ21245930
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistanceQ24644883
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
The Hedgehog and Wnt signalling pathways in cancerQ28189485
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulationQ28200070
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Human homolog of patched, a candidate gene for the basal cell nevus syndromeQ28281033
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2Q28291091
Tissue repair and stem cell renewal in carcinogenesisQ28294006
Identification of an amplified, highly expressed gene in a human gliomaQ28300727
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significanceQ33479917
Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeuticsQ33540741
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.Q33754614
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.Q33772264
Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implicationsQ33820610
Hedgehog signaling is dispensable for adult hematopoietic stem cell functionQ34039421
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemiaQ34157874
Pathways and consequences: Hedgehog signaling in human disease.Q34166365
Cancer stem cells: controversies in multiple myelomaQ34462722
Essential role of stromally induced hedgehog signaling in B-cell malignanciesQ34651265
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesisQ34727652
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regenerationQ35080487
Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myelomaQ35143496
Hedgehog signaling maintains a tumor stem cell compartment in multiple myelomaQ35652021
Sonic hedgehog signalling in T-cell development and activationQ36906677
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapyQ36921866
Multiple myeloma cancer stem cellsQ37029171
Hedgehog signalling: emerging evidence for non-canonical pathwaysQ37462651
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.Q37593483
The reconstruction of transcriptional networks reveals critical genes with implications for clinical outcome of multiple myelomaQ38332196
Insights into the multistep transformation of MGUS to myeloma using microarray expression analysisQ38351001
Discovery of NVP-LDE225, a Potent and Selective Smoothened AntagonistQ39151730
Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.Q39684126
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.Q39879636
Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphomaQ39975250
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.Q42282551
Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis.Q45232009
Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cellsQ46107910
Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic targetQ46202182
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activationQ46388996
Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signalingQ46707481
A molecular fingerprint for medulloblastoma.Q47616912
The Hedgehog receptor Patched controls lymphoid lineage commitmentQ50899169
Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation.Q53338317
Targeting the Hedgehog pathway in cancerQ79397666
Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progressionQ79954750
Cell signaling. A ciliary signaling switchQ80642248
Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cellsQ80833064
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cellsQ81352006
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
P304page(s)5002-5013
P577publication date2012-07-20
P1433published inBloodQ885070
P1476titleCanonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
P478volume120

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