| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Giorgio Sesti | Q42169977 |
| Massimo Federici | Q57002627 | ||
| P2093 | author name string | R Lauro | |
| D Lauro | |||
| P Sbraccia | |||
| M L Hribal | |||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 2099-2111 | |
| P577 | publication date | 2001-10-01 | |
| P1433 | published in | FASEB Journal | Q520194 |
| P1476 | title | Defects of the insulin receptor substrate (IRS) system in human metabolic disorders | |
| P478 | volume | 15 |
| Q51709819 | 12b-hydroxy-des-D-garcigerin A enhances glucose metabolism in insulin-resistant HepG2 cells via the IRS-1/PI3-K/Akt cell signaling pathway. |
| Q30383955 | A Bioinformatics Approach to the Identification of Variants Associated with Type 1 and Type 2 Diabetes Mellitus that Reside in Functionally Validated miRNAs Binding Sites. |
| Q57732779 | A Replication Study of the IRS1, CAPN10, TCF7L2, and PPARG Gene Polymorphisms Associated with Type 2 Diabetes in Two Different Populations of Mexico |
| Q47882327 | A bioluminescence resonance energy transfer 2 (BRET2) assay for monitoring seven transmembrane receptor and insulin receptor crosstalk |
| Q35678143 | A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity |
| Q89495954 | ASSOCIATION OF IRS1 GLY971ARG GENE POLYMORPHISM WITH INSULIN RESISTANCE IN IRANIAN NEWLY DIAGNOSED DIABETIC ADULTS |
| Q27024222 | Aberrant insulin signaling in Alzheimer's disease: current knowledge |
| Q33239296 | Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism |
| Q53688555 | Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. |
| Q35762318 | Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling |
| Q42115571 | Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes. |
| Q26778149 | Alzheimer's Disease: Mechanism and Approach to Cell Therapy |
| Q34712486 | An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors |
| Q88406378 | Anti-Diabetic Effects of Acankoreagenin from the Leaves of Acanthopanax Gracilistylus Herb in RIN-m5F Cells via Suppression of NF-κB Activation |
| Q35043416 | Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? |
| Q44635848 | Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk |
| Q38109537 | Association between insulin receptor substrate 1 Gly972Arg polymorphism and cancer risk |
| Q57040429 | Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes |
| Q40306344 | Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis |
| Q38381198 | Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis |
| Q26739671 | Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans |
| Q33912469 | Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK |
| Q40174504 | C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport. |
| Q44804024 | Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression |
| Q38600701 | Cerebral insulin, insulin signaling pathway, and brain angiogenesis |
| Q42501086 | Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K. |
| Q83018320 | Cloning, chromosomal localization, SNP detection and association analysis of the porcine IRS-1 gene |
| Q29614735 | Critical nodes in signalling pathways: insights into insulin action |
| Q27321064 | Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life |
| Q34487164 | Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity |
| Q33265938 | Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells |
| Q34696555 | Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity |
| Q24337925 | Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2 |
| Q36107128 | E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling |
| Q28741118 | E4orf1: a novel ligand that improves glucose disposal in cell culture |
| Q55046907 | Effect of gastric bypass combined with ileal transportation on type 2 diabetes mellitus. |
| Q54483237 | Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS-1, and Raf-1 in the liver of diabetic rats. |
| Q33833837 | Exploring the evolutionary relationship of insulin receptor substrate family using computational biology. |
| Q28744500 | Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? |
| Q38783258 | Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus |
| Q42459504 | Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia |
| Q36169887 | Genetics of polycystic ovarian syndrome. |
| Q33638451 | Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue |
| Q47821534 | Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats. |
| Q33901226 | Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring |
| Q51277229 | Gly972Arg of IRS-1 and Lys121Gln of PC-1 polymorphisms act in opposite way in polycystic ovary syndrome. |
| Q46625451 | Heterogeneity of type 1 diabetes mellitus |
| Q45182267 | Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation |
| Q37204132 | IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study |
| Q36053009 | IRS-1 and vascular complications in diabetes mellitus |
| Q57489950 | IRS-1 genetic polymorphism (r.2963G>A) in type 2 diabetes mellitus patients associated with insulin resistance |
| Q37683511 | IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33. |
| Q41809347 | IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. |
| Q36852845 | IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk. |
| Q41851616 | IRS1, TCF7L2, ADRB1, PPARG, and HHEX polymorphisms associated with atherogenic risk in Mexican population. |
| Q41458783 | IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation |
| Q38640616 | Identification of an early transcriptomic signature of insulin resistance and related diseases in lymphomonocytes of healthy subjects. |
| Q64105070 | Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer |
| Q44792800 | Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes |
| Q36761492 | Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats |
| Q44245865 | Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche. |
| Q39565163 | Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. |
| Q30571118 | Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data |
| Q38328560 | Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells |
| Q34321195 | Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins |
| Q35598032 | Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study |
| Q28533530 | Insulin receptor substrate 2 is required for testicular development |
| Q42474195 | Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport |
| Q42818693 | Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. |
| Q36324480 | Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts |
| Q36826889 | Insulin receptor-independent upregulation of cellular glucose uptake |
| Q35711939 | Insulin signaling defects in type 2 diabetes |
| Q34534983 | Insulin signaling pathways in time and space. |
| Q37634961 | Insulin signaling regulating genes: effect on T2DM and cardiovascular risk. |
| Q24301972 | Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells |
| Q30160247 | Interaction between Brk kinase and insulin receptor substrate-4. |
| Q28508130 | MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632 |
| Q42505185 | Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced type 1 diabetes mellitus. |
| Q47214793 | Microphysiological Analysis Platform of Pancreatic Islet β-Cell Spheroids |
| Q36699198 | Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats |
| Q33612153 | Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways |
| Q37437295 | Molecular mechanisms involved in NAFLD progression |
| Q35129282 | Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4. |
| Q38112371 | Network nonlinearities in drug treatment |
| Q36565904 | Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates |
| Q44563303 | Oestrogen improves glucose metabolism and insulin signal transduction in HepG2 cells |
| Q26825444 | Optimizing IGF-I for skeletal muscle therapeutics |
| Q42831349 | Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo |
| Q58259806 | Overweight of Korean male workers and genetic polymorphism of insulin receptor substrate 1 (IRS1) gene |
| Q37151820 | Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases. |
| Q42412809 | PTEN in liver diseases and cancer |
| Q37321868 | Pharmacodynamic/pharmacogenomic modeling of insulin resistance genes in rat muscle after methylprednisolone treatment: exploring regulatory signaling cascades |
| Q38684361 | Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus. |
| Q90267161 | Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine |
| Q90352966 | Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway |
| Q51411759 | Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis. |
| Q45382973 | Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study |
| Q38200161 | Possible roles of insulin signaling in osteoblasts |
| Q54312638 | Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome. |
| Q37509156 | Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa |
| Q36578889 | Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling. |
| Q34343619 | Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation |
| Q43270519 | Reduced pancreatic beta-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats. |
| Q35233875 | Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children |
| Q37499435 | Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β. |
| Q36286323 | Review article: an unexpected virus-host interaction--the hepatitis C virus-diabetes link |
| Q42247586 | Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription |
| Q28082188 | Role of IGF-I signaling in muscle bone interactions |
| Q38123234 | Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus |
| Q38605717 | Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats |
| Q42323658 | Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein |
| Q37403970 | Serine kinases of insulin receptor substrate proteins |
| Q37039638 | Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks. |
| Q36674827 | Stress, the endoplasmic reticulum, and insulin resistance |
| Q43139153 | Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact? |
| Q34979386 | Template to improve glycemic control without reducing adiposity or dietary fat. |
| Q54456152 | The IRS2 Gly1057Asp variant is associated with human longevity. |
| Q35033208 | The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study |
| Q42053106 | The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage |
| Q35147654 | The emerging role of insulin-like growth factors in testis development and function |
| Q28513514 | The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth |
| Q42814621 | The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. |
| Q44946396 | The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies |
| Q27002724 | The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases |
| Q37113882 | The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. |
| Q47281625 | The role of gut in type 2 diabetes mellitus during whole body gamma irradiation in high-fat diet Wistar rats. |
| Q57279877 | The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects |
| Q36463221 | The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities |
| Q47835944 | The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes? |
| Q41910421 | Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion. |
| Q24811827 | Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction |
| Q33957907 | Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans |
| Q54372901 | Xenopus laevis insulin receptor substrate IRS-1 is important for eye development. |
| Q35839862 | Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. |
| Q51742198 | miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes. |
| Q36878582 | microRNA-141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2. |
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