Insulin-like growth factors: actions on the skeleton.

scientific article published on 6 April 2018

Insulin-like growth factors: actions on the skeleton. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1530/JME-17-0298
P932PMC publication ID5966339
P698PubMed publication ID29626053

P2093author name stringShoshana Yakar
Haim Werner
Cliff Rosen
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A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.Q34241257
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Fluid shear stress induces beta-catenin signaling in osteoblasts.Q40481605
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Parathyroid Hormone Levels in Healthy Children and AdolescentsQ40773215
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Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal miceQ41874233
Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutationQ41920574
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Short Stature Associated with a Novel Heterozygous Mutation in theInsulin-Like Growth Factor 1GeneQ41936501
Partial primary deficiency of insulin-like growth factor (IGF)-I activity associated with IGF1 mutation demonstrates its critical role in growth and brain development.Q41937526
Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formationQ42475736
Characterization of the receptor for insulin-like growth factor II in bone cellsQ42493147
Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse boneQ42525601
Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 DeficiencyQ43120001
Identification of IGFBP-3 fragments generated by KLK2 and prevention of fragmentation by KLK2-inhibiting peptidesQ43151753
Dihydrotestosterone is a determinant of calcaneal bone mineral density in men.Q43280600
Perturbations in Bone Formation and Resorption in Insulin-Like Growth Factor Binding Protein-3 Transgenic MiceQ43453827
Insulin-like growth factor-I supports formation and activation of osteoclastsQ43458688
Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic miceQ43584843
Circulating levels of insulin-like growth factors and their binding proteins in patients with chronic liver disease: lack of correlation with bone mineral densityQ43586173
Homozygous mutation of the IGF1 receptor gene in a patient with severe pre- and postnatal growth failure and congenital malformationsQ43641976
Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular.Q43743266
PTH differentially regulates expression of RANKL and OPG.Q43832667
Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men.Q43926688
Increased fracture frequency in adult patients with hypopituitarism and GH deficiencyQ44025099
Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosisQ44090259
Bone formation in the context of growth retardation induced by hIGFBP-1 overexpression in transgenic mice.Q44254001
Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plateQ44327491
IGF2 modulates the microenvironment for osteoclastogenesisQ44571146
The skeletal structure of insulin-like growth factor I-deficient miceQ44588867
An age-related decrease in the concentration of insulin-like growth factor binding protein-5 in human cortical boneQ44618886
Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R geneQ44690326
Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.Q44777062
Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathwaysQ44812041
A potentially deleterious role of IGFBP-2 on bone density in aging men and womenQ44920762
Insulin-like growth factor I is a determinant of hip bone mineral density in men less than 60 years of age: MINOS study.Q44979340
Skeletal effects of cyclic recombinant human growth hormone and salmon calcitonin in osteopenic postmenopausal womenQ45063585
Primary structure of human insulin-like growth factor II.Q45064062
Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.Q45759821
A New Homozygous IGF1R Variant Defines a Clinically Recognizable Incomplete Dominant form of SHORT Syndrome.Q45938326
Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.Q45989753
Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shearQ46072489
Role of IGF-I signaling in regulating osteoclastogenesisQ46171428
Effects of short term administration of recombinant human growth hormone to elderly peopleQ46191802
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Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.Q46324113
Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 geneQ46410636
Insulin-like growth factor-I treatment in primary growth hormone insensitivity: effect of recombinant human IGF-I (rhIGF-I) and rhIGF-I/rhIGF-binding protein-3 complexQ46490214
Skeletal unloading induces resistance to insulin-like growth factor I.Q46495116
Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature OsteoblastsQ46693517
The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. .Q53328360
Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice.Q53568079
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Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice.Q53971094
Parental imprinting of the mouse insulin-like growth factor II gene.Q55052428
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5Q55216568
Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone rQ56883933
A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficitQ56901705
High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegalyQ57250965
Parallel-plate fluid flow systems for bone cell stimulationQ57633489
Somatomedin: Proposed Designation for Sulphation FactorQ59080510
Congenic Mice Providein VivoEvidence for a Genetic Locus that Modulates Serum Insulin-Like Growth Factor-I and Bone AcquisitionQ62723163
Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfismQ67516243
Growth enhancement of transgenic mice expressing human insulin-like growth factor IQ67979226
Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-IQ68096397
Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariaeQ68097816
Subcellular location of IGF-I in chondrocytes from rat rib growth plateQ68158968
Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-IIQ68431796
Regulation by GH of insulin-like growth factor-I mRNA expression in rat epiphyseal growth plate as studied with in-situ hybridizationQ68509750
Plasma clearance of chicken and human insulin-like growth factor-I and their association with circulating binding proteins in chickensQ68768728
Human somatomedin. Determination, occurrence, biological activity and purificationQ69099474
Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I), IGF-II and des(1-3)IGF-I in ratsQ70120018
Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat boneQ70577706
Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed pubertyQ70660395
Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly womenQ71053201
Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome--a clinical research center study. GHIS Collaborative GroupQ71477205
Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinasesQ71661124
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cellsQ71679363
A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiencyQ71687669
Further Purification and Characterization of Sulfation Factor and Thymidine Factor from Acromegalic PlasmaQ71752023
Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized ratsQ72326673
Insulin-like growth factor I supports differentiation of cultured osteoblast-like cellsQ72385551
Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulationQ72564734
Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with ageQ72824088
Two-year treatment of growth hormone (GH) receptor deficiency with recombinant insulin-like growth factor I in 22 children: comparison of two dosage levels and to GH-treated GH deficiencyQ73047841
Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosisQ73321928
Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolismQ73470643
Therapy for 6.5-7.5 years with recombinant insulin-like growth factor I in children with growth hormone insensitivity syndrome: a clinical research center studyQ73739015
Effects of estrogen and growth hormone on skeleton in the ovariectomized rat with hypophysectomyQ73847716
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferationQ73941872
Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY studyQ74141058
Recombinant human insulin-like growth factor I has significant anabolic effects in adults with growth hormone receptor deficiency: studies on protein, glucose, and lipid metabolismQ74352435
Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formationQ74411385
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationQ74742272
Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopeniaQ74805663
Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site-specific mannerQ77379161
Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegalyQ77767545
Parathyroid hormone stimulates release of insulin-like growth factor-I (IGF-I) and IGF-II from neonatal mouse calvaria in organ cultureQ46716371
Prevalence of vertebral fractures in men with acromegaly.Q46721207
Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with agingQ46732168
Vertebral fracture assessment in acromegalyQ46759557
IGF-I receptor is required for the anabolic actions of parathyroid hormone on boneQ46771350
Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I.Q46780650
Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesisQ46809661
The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly womenQ46972658
Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gainQ47252551
Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weightQ47319737
Insulin-like growth factor I improves height in growth hormone insensitivity: two years' resultsQ47361981
An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.Q47604904
Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses.Q47840400
Hypoxic stress enhances osteoclast differentiation via increasing IGF2 production by non-osteoclastic cellsQ47849526
Stimulation of bone formation in vivo by insulin-like growth factor-II in ratsQ47953304
Skeletal effects of two years of treatment with low physiological doses of recombinant human growth hormone (GH) in patients with adult-onset GH deficiencyQ47976499
Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndromeQ48126284
IGF-1 Receptor Expression on Circulating Osteoblast Progenitor Cells Predicts Tissue-Based Bone Formation Rate and Response to Teriparatide in Premenopausal Women With Idiopathic Osteoporosis.Q48218486
Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant ratsQ48245415
Microarray analysis of the in vivo effects of hypophysectomy and growth hormone treatment on gene expression in the rat.Q48835553
Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic miceQ48901708
Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expressionQ48909407
An experimental model of partial insulin-like growth factor-1 deficiency in miceQ49022188
The effects of testosterone and dihydrotestosterone on hypothalamic regulation of growth hormone secretionQ49086583
Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice.Q50782082
Short-term effects of high dose estrogen on tibiae of growing male rats.Q50974261
The effect of hypophysectomy and growth hormone on the incorporation of labeled sulfate into tibial epiphyseal and nasal cartilage of the rat.Q51331778
Bioassay of hypophyseal growth hormone; the tibia test.Q51361746
Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice.Q51586289
Three year IGF-I treatment of children with Laron syndrome.Q51587258
Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia.Q51771247
Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.Q51819758
Postnatal growth and bone mass in mice with IGF-I haploinsufficiency.Q51822603
Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A.Q52042509
Effects of liver-derived insulin-like growth factor I on bone metabolism in mice.Q52112899
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.Q52142765
Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy.Q52173480
Hemizygosity at the insulin-like growth factor I receptor (IGF1R) locus and growth failure in the ring chromosome 15 syndrome.Q52510631
Specific, time-dependent actions of low-dose ethinyl estradiol administration on the episodic release of growth hormone, follicle-stimulating hormone, and luteinizing hormone in prepubertal girls with Turner's syndrome.Q52517385
Endocrinology--the way we were: a personal history of somatomedin.Q53245222
Effects of insulin-like growth factor binding proteins in bone -- a matter of cell and siteQ36964578
The somatomedin hypothesis 2007: 50 years laterQ36994835
Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloadingQ37105615
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolismQ37123969
Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged miceQ37219630
Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactionsQ37283796
Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptorQ37349402
A novel deletion of IGF1 in a patient with idiopathic short stature provides insight Into IGF1 haploinsufficiency.Q37428944
Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences.Q37591754
Immobilization and bone structure in humansQ37773475
IGF1R mutations as cause of SGA.Q37852215
Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancerQ37941372
IGF-1 and BRCA1 signalling pathways in familial cancerQ38062611
Molecular IGF-1 and IGF-1 receptor defects: from genetics to clinical managementQ38079960
Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formationQ38308154
Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restrictionQ38318680
Structural and functional analysis of the insulin-like growth factor I receptor gene promoterQ38325320
Characterization of the rat insulin-like growth factor I gene promoters and identification of a minimal exon 2 promoterQ38347482
Paracrine Overexpression of IGFBP‐4 in Osteoblasts of Transgenic Mice Decreases Bone Turnover and Causes Global Growth RetardationQ38354878
The relationship among circulating insulin-like growth factor components, biochemical markers of bone turnover and bone mineral density in postmenopausal women under the age of 60.Q38527424
60 YEARS OF NEUROENDOCRINOLOGY: AcromegalyQ38542023
Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms.Q38847165
Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult miceQ38977757
Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenonQ39104777
The Relationship Between Calciotropic Hormones, IGF-1, and Bone Mass Across Pubertal StagesQ39346765
Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinaseQ39774749
A dual effector theory of growth-hormone actionQ39837319
Regulation of rapid signal transducer and activator of transcription-5 phosphorylation in the resting cells of the growth plate and in the liver by growth hormone and feeding.Q39862209
Reduced serum IGF-1 associated with hepatic osteodystrophy is a main determinant of low cortical but not trabecular bone massQ40043672
Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I.Q40143543
Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodelingQ40286652
P921main subjectpreproinsulinQ7240673
P577publication date2018-04-06
P1433published inJournal of Molecular EndocrinologyQ15716709
P1476titleInsulin-like growth factors: actions on the skeleton.

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