| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.C100462200 |
| P698 | PubMed publication ID | 11533044 |
| P50 | author | Joanne L. Thorvaldsen | Q106647248 |
| Morris J. Birnbaum | Q40173515 | ||
| P2093 | author name string | Cho H | |
| Chu Q | |||
| Feng F | |||
| P433 | issue | 42 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glucose | Q37525 |
| P304 | page(s) | 38349-38352 | |
| P577 | publication date | 2001-08-31 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice | |
| P478 | volume | 276 |
| Q24298847 | 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling |
| Q36236507 | A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain |
| Q38877389 | A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk |
| Q35974696 | A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 |
| Q40484912 | A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death |
| Q36156412 | A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. |
| Q39015140 | A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer |
| Q24598593 | A mosaic activating mutation in AKT1 associated with the Proteus syndrome |
| Q34549521 | A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice |
| Q36646199 | A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis |
| Q30572456 | A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis |
| Q35942505 | A simple matter of life and death-the trials of postnatal Beta-cell mass regulation |
| Q36499749 | A survival guide to early T cell development |
| Q52731012 | A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206. |
| Q47093800 | AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. |
| Q68692596 | AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions |
| Q35128548 | AKT signalling in the failing heart |
| Q42511240 | AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation |
| Q39255027 | AKT/PKB Signaling: Navigating the Network |
| Q34786288 | AKT1 G205T genotype influences obesity-related metabolic phenotypes and their responses to aerobic exercise training in older Caucasians |
| Q33871498 | AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. |
| Q90369857 | AKT1 regulates endoplasmic reticula stress and mediates adaptive response of pancreatic β-cells |
| Q85964497 | AKT2 is essential to maintain podocyte viability and function during chronic kidney disease |
| Q51732736 | AKT2 is the predominant AKT isoform expressed in human skeletal muscle. |
| Q47429367 | Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids |
| Q33812880 | Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells |
| Q37247491 | Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans |
| Q37485515 | Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. |
| Q36733736 | Achieving specificity in Akt signaling in cancer |
| Q38824661 | Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling |
| Q48626001 | Activated central galanin type 1 receptor alleviated insulin resistance in diabetic rat muscle |
| Q30838969 | Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity. |
| Q39094985 | Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice |
| Q34752434 | Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. |
| Q37163613 | Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology |
| Q41937385 | Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice |
| Q46390661 | Age-related changes of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: an immunohistochemical study |
| Q28731496 | Aging and the Mammalian regulatory triumvirate |
| Q36815701 | Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS |
| Q92494933 | Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis |
| Q36916238 | Akt activation protects liver cells from apoptosis in rats during acute cold exposure. |
| Q24656202 | Akt and CHIP coregulate tau degradation through coordinated interactions |
| Q35684972 | Akt and PTEN: beta-cell mass and pancreas plasticity. |
| Q39338602 | Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). |
| Q28749276 | Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition |
| Q35442741 | Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. |
| Q36917074 | Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents |
| Q39659127 | Akt inhibitors reduce glucose uptake independently of their effects on Akt. |
| Q34989027 | Akt is required for Stat5 activation and mammary differentiation |
| Q101038777 | Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model |
| Q37800267 | Akt isoforms and glucose homeostasis – the leptin connection |
| Q42276923 | Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities |
| Q30494741 | Akt isoforms differentially regulate neutrophil functions |
| Q26851565 | Akt isoforms in vascular disease |
| Q92069609 | Akt modes of stem cell regulation: more than meets the eye? |
| Q39787858 | Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation |
| Q37721192 | Akt signaling in platelets and thrombosis |
| Q33187686 | Akt signaling regulates side population cell phenotype via Bcrp1 translocation. |
| Q42509383 | Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. |
| Q46968816 | Akt-interacting proteins: attractive opposites. focus on "Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways". |
| Q37525730 | Akt-mediated foxo1 inhibition is required for liver regeneration. |
| Q34162552 | Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development |
| Q34276940 | Akt/protein kinase B promotes organ growth in transgenic mice |
| Q47134589 | Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. |
| Q35901256 | Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. |
| Q33871508 | Akt1 and Akt2 promote peripheral B-cell maturation and survival |
| Q36066171 | Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization |
| Q37488229 | Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development |
| Q35130800 | Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning |
| Q35151491 | Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer |
| Q30458585 | Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function |
| Q48793541 | Akt1 deficiency modulates reward learning and reward prediction error in mice |
| Q34049042 | Akt1 deletion prevents lung tumorigenesis by mutant K-ras |
| Q36714045 | Akt1 gene deletion and stroke |
| Q33917074 | Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest |
| Q24676614 | Akt1 in endothelial cell and angiogenesis |
| Q33905832 | Akt1 in the cardiovascular system: friend or foe? |
| Q37321172 | Akt1 is critical for acute inflammation and histamine-mediated vascular leakage |
| Q37163727 | Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations. |
| Q34559260 | Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling |
| Q34550955 | Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil |
| Q28574706 | Akt1 regulates a JNK scaffold during excitotoxic apoptosis |
| Q42482049 | Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis |
| Q42426022 | Akt2 and Akt3 play a pivotal role in malignant gliomas |
| Q37326916 | Akt2 and SGK3 are both determinants of postnatal hair follicle development. |
| Q37079752 | Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis |
| Q59799713 | Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression |
| Q41969432 | Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. |
| Q38349186 | Akt2 is required for hepatic lipid accumulation in models of insulin resistance. |
| Q64226327 | Akt2 mediates glucocorticoid resistance in lymphoid malignancies through FoxO3a/Bim axis and serves as a direct target for resistance reversal |
| Q33885216 | Akt2 modulates glucose availability and downstream apoptotic pathways during development |
| Q42817295 | Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles |
| Q37297743 | Akt2 regulates cardiac metabolism and cardiomyocyte survival |
| Q40567186 | Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis |
| Q46158188 | Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation |
| Q52607535 | Akt2: a critical regulator of cardiomyocyte survival and metabolism. |
| Q30491624 | Akt3 is responsible for the survival and proliferation of embryonic stem cells |
| Q36954825 | Akt3 knockdown induces mitochondrial dysfunction in human cancer cells |
| Q92564624 | Akt3-Mediated Protection Against Inflammatory Demyelinating Disease |
| Q34223641 | Akt: a double-edged sword in cell proliferation and genome stability |
| Q42366521 | Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis |
| Q64924418 | Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133. |
| Q37476517 | Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure |
| Q34872991 | Anaphylactic shock depends on PI3K and eNOS-derived NO. |
| Q37428684 | Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. |
| Q35141925 | Antenatal corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle |
| Q34157973 | Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. |
| Q36512463 | Antidiabetogenic effects of chromium mitigate hyperinsulinemia-induced cellular insulin resistance via correction of plasma membrane cholesterol imbalance |
| Q92702134 | Antioxidant and Cytoprotective Effects of (-)-Epigallocatechin-3-(3″-O-methyl) Gallate |
| Q34048466 | Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. |
| Q36301823 | Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways |
| Q50539880 | Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics |
| Q35586717 | Body building: regulation of shape and size by PI3K/TOR signaling during development |
| Q42110947 | Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. |
| Q34998388 | Both GPER and membrane oestrogen receptor-α activation protect ventricular remodelling in 17β oestradiol-treated ovariectomized infarcted rats |
| Q37692074 | Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases |
| Q37357258 | Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle |
| Q64040124 | Brown fat organogenesis and maintenance requires AKT1 and AKT2 |
| Q34401014 | Calcineurin signaling regulates human islet {beta}-cell survival. |
| Q37461063 | Can the role of genetic factors in schizophrenia be enlightened by studies of candidate gene mutant mice behaviour? |
| Q36061754 | Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart |
| Q36876219 | Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue |
| Q35543645 | Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment. |
| Q24317248 | Cardiac regulation by phosphoinositide 3-kinases and PTEN |
| Q42484804 | Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha |
| Q41912188 | Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. |
| Q35484864 | Ceramides as modulators of cellular and whole-body metabolism |
| Q33429968 | Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance |
| Q34102206 | Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes |
| Q38740079 | Comparison of pulsatile vs. continuous administration of human placental growth hormone in female C57BL/6J mice |
| Q79736219 | Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha |
| Q52714549 | Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism. |
| Q47834227 | Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts |
| Q36203847 | Contraction signaling to glucose transport in skeletal muscle |
| Q42132463 | Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure |
| Q40036226 | Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II. |
| Q36592817 | Control of mammalian oocyte growth and early follicular development by the oocyte PI3 kinase pathway: new roles for an old timer. |
| Q44743796 | Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia |
| Q57169647 | Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration |
| Q29614735 | Critical nodes in signalling pathways: insights into insulin action |
| Q36968719 | Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis |
| Q27640282 | Crystal structure of an inactive Akt2 kinase domain |
| Q37549664 | Current perspectives on Akt Akt-ivation and Akt-ions |
| Q39126378 | Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors |
| Q36168356 | DNA methylation Landscape of body size variation in sheep |
| Q24627067 | De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes |
| Q35931063 | Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm |
| Q40051013 | Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells |
| Q35632195 | Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2 |
| Q36246003 | Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia |
| Q54651796 | Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. |
| Q55333348 | Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy. |
| Q33301344 | Deletion of PKBalpha/Akt1 affects thymic development |
| Q36159631 | Development of a new model system to dissect isoform specific Akt signalling in adipocytes |
| Q46724454 | Developmental regulation of protein kinase B activation is isoform specific in skeletal muscle of neonatal pigs |
| Q36388391 | Dichotomy effects of Akt signaling in breast cancer |
| Q90132517 | Differential Diabetogenic Effect of Pitavastatin and Rosuvastatin, in vitro and in vivo |
| Q43050403 | Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action. |
| Q38532367 | Differential control of muscle mass in type 1 and type 2 diabetes mellitus |
| Q33614014 | Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. |
| Q54979781 | Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression. |
| Q35107276 | Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes |
| Q34721519 | Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt |
| Q52681513 | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. |
| Q30415974 | Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice |
| Q42928039 | Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure |
| Q33648295 | Dissecting the mechanism of insulin resistance using a novel heterodimerization strategy to activate Akt. |
| Q37361165 | Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation |
| Q35129460 | Distinct actions of akt1 on skeletal architecture and function |
| Q36320600 | Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition |
| Q33854404 | Distinct roles of the three Akt isoforms in lactogenic differentiation and involution |
| Q26851604 | Diverse mechanisms of AKT pathway activation in human malignancy |
| Q84338645 | Does obesity reduce load-induced muscle hypertrophy? |
| Q34150841 | Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice |
| Q35965439 | Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. |
| Q35056963 | Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules |
| Q90402142 | Effect of type 2 diabetes mellitus caveolin-3 K15N mutation on glycometabolism |
| Q42460800 | Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts |
| Q30437684 | Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression |
| Q36462135 | Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice |
| Q34144300 | Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates |
| Q49960687 | Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis |
| Q34286604 | Endothelial nitric oxide synthase transgenic models of endothelial dysfunction |
| Q47146373 | Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. |
| Q33737298 | Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways |
| Q24685447 | Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway |
| Q24534217 | Essential role of PDK1 in regulating cell size and development in mice |
| Q33837248 | Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma |
| Q58876748 | Evidence for an Akt-kinase/NO/cGMP pathway in the cochlea of guinea pigs |
| Q27340176 | Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice |
| Q91142496 | Evolving concepts in the pathogenesis of uraemic cardiomyopathy |
| Q40238333 | Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents |
| Q52746297 | Exercise Training and Epigenetic Regulation: Multilevel Modification and Regulation of Gene Expression. |
| Q36204909 | Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling |
| Q39656536 | Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. |
| Q29615120 | Exploiting the PI3K/AKT pathway for cancer drug discovery |
| Q54623862 | Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-δ in normal human dermal fibroblasts. |
| Q35589717 | Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions |
| Q35598846 | FOSL1 is integral to establishing the maternal-fetal interface |
| Q39385262 | FOXO transcription factors at the interface of metabolism and cancer |
| Q35633256 | Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle |
| Q37628713 | Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research |
| Q37285629 | Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. |
| Q36508885 | GSK3beta is a negative regulator of platelet function and thrombosis |
| Q53246719 | Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. |
| Q36493849 | Gender-specific response to isoflurane preconditioning in focal cerebral ischemia |
| Q33664428 | Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation |
| Q35214648 | Genetic manipulation of the insulin signalling cascade in mice--potential insight into the pathomechanism of type 2 diabetes |
| Q37305035 | Genetic modelling of the PTEN/AKT pathway in cancer research |
| Q33240233 | Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells |
| Q54795142 | HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis. |
| Q28296350 | Haploinsufficiency of akt1 prolongs the lifespan of mice |
| Q39670813 | Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). |
| Q35039330 | Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis |
| Q36271468 | Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice |
| Q47800119 | Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines |
| Q43600621 | High tidal volume mechanical ventilation elicits increased activity in protein kinase B and c-Jun NH2-terminal kinase pathways in mouse diaphragm |
| Q44208213 | High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway |
| Q44594449 | High-fat diet and leptin treatment alter skeletal muscle insulin-stimulated phosphatidylinositol 3-kinase activity and glucose transport |
| Q38017247 | Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling |
| Q38905205 | Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle |
| Q36445850 | IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival |
| Q40509516 | Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors |
| Q24338582 | Identification of a proline-rich Akt substrate as a 14-3-3 binding partner |
| Q42806554 | Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes. |
| Q98164522 | Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer |
| Q44792800 | Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes |
| Q37413596 | Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium |
| Q42136011 | In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis |
| Q30382377 | Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling. |
| Q39565163 | Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. |
| Q59137669 | Inhibition of AKT suppresses the initiation and progression of -associated mammary tumors |
| Q33920097 | Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape |
| Q28202566 | Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells |
| Q51761848 | Inhibition of protein kinase B activity induces cell cycle arrest and apoptosis during early G₁ phase in CHO cells. |
| Q34145575 | Inhibition of protein kinase B/Akt. implications for cancer therapy |
| Q37099725 | Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT) |
| Q28590549 | Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness |
| Q30377910 | Insulin Signaling and Heart Failure. |
| Q36161382 | Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. |
| Q50226931 | Insulin regulation of gluconeogenesis |
| Q43245108 | Insulin resistance and muscle metabolism in chronic kidney disease |
| Q33917344 | Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats |
| Q36321818 | Insulin signaling and the regulation of glucose transport. |
| Q35940001 | Insulin signaling in heart muscle: lessons from genetically engineered mouse models. |
| Q35146125 | Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing |
| Q44912770 | Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm |
| Q36160490 | Insulin's expanding control of forkheads |
| Q90482471 | Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle |
| Q46414639 | Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle. |
| Q36757048 | Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival |
| Q36392645 | Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment |
| Q39240626 | Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells |
| Q47673795 | Involvement of Akt1/protein kinase Balpha in tumor conditioned medium-induced endothelial cell migration and survival in vitro |
| Q39270158 | Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition |
| Q46801587 | Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients |
| Q33824965 | Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. |
| Q24307898 | Kinetic mechanism of AKT/PKB enzyme family |
| Q35031186 | Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways |
| Q38205763 | Knockout mouse models of insulin signaling: Relevance past and future |
| Q37040174 | Lack of AKT in adipocytes causes severe lipodystrophy. |
| Q36562949 | Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades |
| Q41997926 | Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. |
| Q24672400 | Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies |
| Q37322383 | Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside |
| Q64230296 | Lipotoxicity and Cell Maintenance in Obesity and Type 2 Diabetes |
| Q90642854 | Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice |
| Q40313842 | Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity |
| Q36753752 | Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease |
| Q34898828 | Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice |
| Q35921170 | Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo |
| Q35105632 | Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B |
| Q34988349 | Lymphocide: cytokines and the control of lymphoid homeostasis |
| Q37184853 | Lysophosphatidic acid induces cell migration through the selective activation of Akt1. |
| Q33764821 | Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis |
| Q36196806 | Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice |
| Q35830027 | Magnolia bioactive constituent 4-O-methylhonokiol prevents the impairment of cardiac insulin signaling and the cardiac pathogenesis in high-fat diet-induced obese mice |
| Q35946247 | Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum |
| Q42519955 | Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q89811716 | Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence |
| Q42379848 | Mechanisms of vascular insulin resistance: a substitute Akt? |
| Q37584923 | Mechanotransduction drives post ischemic revascularization through K(ATP) channel closure and production of reactive oxygen species. |
| Q35906419 | Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. |
| Q51471908 | Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans. |
| Q34935025 | Microarray analysis of gene expression profiles of Schistosoma japonicum derived from less-susceptible host water buffalo and susceptible host goat |
| Q37941864 | Mitochondrial regulation of cell cycle and proliferation |
| Q50423780 | Molecular Regulation of Sprouting Angiogenesis |
| Q28566353 | Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40 |
| Q27006868 | Molecular basis of physiological heart growth: fundamental concepts and new players |
| Q40370841 | Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway |
| Q33893897 | Molecular mechanism of insulin resistance in obesity and type 2 diabetes |
| Q34420707 | Molecular mechanisms of insulin resistance |
| Q34877773 | Molecular mechanisms of insulin resistance in type 2 diabetes mellitus |
| Q30383611 | Molecular substrates of schizophrenia: homeostatic signaling to connectivity |
| Q37411066 | Multimodal imaging reveals a role for Akt1 in fetal cardiac development. |
| Q33915992 | Multiple roles and therapeutic implications of Akt signaling in cancer. |
| Q91627444 | Muscle wasting: A review of exercise, classical and non-classical RAS axes |
| Q35879528 | Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes |
| Q27650096 | Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance |
| Q36908289 | Myocardial AKT: the omnipresent nexus |
| Q35949606 | Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation |
| Q51831535 | NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors. |
| Q53059092 | Nephro-protective effect of granulocyte colony-stimulating factor in streptozotocin induced diabetic rats. |
| Q28571833 | Neuregulin signaling on glucose transport in muscle cells |
| Q90114172 | Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development |
| Q34423863 | Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia |
| Q33267049 | Neuroprotection and enhancement of neurite outgrowth with small molecular weight compounds from screens of chemical libraries |
| Q37629872 | Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish |
| Q52644526 | New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. |
| Q39419046 | New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling |
| Q39555624 | Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. |
| Q28505512 | Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death |
| Q34564794 | Normal T-cell development and immune functions in TRIM-deficient mice |
| Q33818946 | Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. |
| Q40492173 | Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway |
| Q35572443 | Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways |
| Q35213690 | Novel concepts in insulin regulation of hepatic gluconeogenesis |
| Q35595721 | Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice |
| Q24650827 | Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival |
| Q42811747 | Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. |
| Q36272908 | Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. |
| Q42091923 | Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. |
| Q37568650 | Obestatin as a regulator of adipocyte metabolism and adipogenesis |
| Q91259716 | Oncogenic AKTivation by methylation |
| Q39126224 | Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. |
| Q47660630 | Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response |
| Q35145125 | Opposing functions of Akt isoforms in lung tumor initiation and progression |
| Q36932339 | Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. |
| Q28483822 | Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish |
| Q34121608 | PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival |
| Q33341346 | PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle |
| Q37096773 | PERK-dependent regulation of IAP translation during ER stress |
| Q24300933 | PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms |
| Q91714664 | PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics |
| Q26862544 | PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms |
| Q37974734 | PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. |
| Q91783484 | PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells |
| Q35603373 | PI3K/Akt and apoptosis: size matters |
| Q37310202 | PI3K/Akt: getting it right matters |
| Q28383083 | PI3K/PTEN signaling in angiogenesis and tumorigenesis |
| Q29994856 | PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia |
| Q34942330 | PTEN function in mammalian cell size regulation |
| Q28239790 | PTEN is a protein tyrosine phosphatase for IRS1 |
| Q37270423 | PTEN signaling in brain: neuropathology and tumorigenesis. |
| Q64075627 | Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt |
| Q42166673 | Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. |
| Q35088795 | Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons |
| Q35796563 | Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation |
| Q35073075 | Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation |
| Q36692779 | Phosphatidylinositol 4,5-bisphosphate reverses endothelin-1-induced insulin resistance via an actin-dependent mechanism |
| Q35181798 | Phosphoinositide 3-kinase signalling--which way to target? |
| Q42572788 | Phosphorylation of ATXN1 at Ser776 in the cerebellum |
| Q40944784 | Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition |
| Q34886884 | Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival. |
| Q38880458 | Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. |
| Q39185840 | Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14 |
| Q48309099 | Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter |
| Q36682368 | Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy |
| Q34185787 | Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes |
| Q36715658 | Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1. |
| Q38687010 | Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis |
| Q48768912 | Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes |
| Q24518494 | Protein kinase cascades in the regulation of cardiac hypertrophy |
| Q40241184 | Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions |
| Q42702654 | Quercetin regresses Dalton's lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism |
| Q37333782 | Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. |
| Q46972339 | Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling |
| Q35895004 | Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2). |
| Q35235848 | Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity |
| Q41837867 | Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth |
| Q37812658 | Recent development of anticancer therapeutics targeting Akt. |
| Q35174581 | Redox regulation of protein kinases |
| Q43270519 | Reduced pancreatic beta-cell mass is associated with decreased FoxO1 and Erk1/2 protein phosphorylation in low-protein malnourished rats. |
| Q26998765 | Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging |
| Q29248612 | Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases |
| Q54567807 | Regulation of arterial blood pressure by Akt1-dependent vascular relaxation. |
| Q89873336 | Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2 |
| Q29615166 | Regulation of cardiac hypertrophy by intracellular signalling pathways |
| Q37005273 | Regulation of gastric acid secretion by PKB/Akt2 |
| Q36736100 | Regulation of muscle mass by growth hormone and IGF-I. |
| Q37337834 | Regulation of pancreas plasticity and malignant transformation by Akt signaling. |
| Q38131857 | Regulation of placental angiogenesis |
| Q33976316 | Regulation of renal tubular glucose reabsorption by Akt2/PKBβ |
| Q35128706 | Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models |
| Q33830668 | Regulation of the JNK3 signaling pathway during islet isolation: JNK3 and c-fos as new markers of islet quality for transplantation |
| Q36364259 | Regulation of the PI3K/Akt pathway during decidualization of endometrial stromal cells |
| Q35176637 | Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity. |
| Q37620749 | Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2. |
| Q42802836 | Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport |
| Q64238726 | Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling |
| Q37687611 | Restoring miR122 in human stem-like hepatocarcinoma cells, prompts tumor dormancy through Smad-independent TGF-β pathway. |
| Q34642281 | RhoGAP: the next big thing for small mice? |
| Q28509294 | Role for Akt3/protein kinase Bgamma in attainment of normal brain size |
| Q52666361 | Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal. |
| Q39808926 | Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts |
| Q34997136 | Role of Akt/protein kinase B in metabolism. |
| Q42497456 | Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle |
| Q28294651 | Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression |
| Q34866669 | Role of X-linked inhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide-3 kinase/Akt pathway. |
| Q46747398 | Role of skeletal muscle-fibre type in regulation of glucose metabolism in middle-aged subjects with impaired glucose tolerance during a long-term exercise and dietary intervention |
| Q35572388 | S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy. |
| Q36072704 | SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption |
| Q42831990 | SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes |
| Q37763949 | SHIP2 and its involvement in various diseases |
| Q37694687 | SILAM for quantitative proteomics of liver Akt1/PKBα after burn injury |
| Q42355569 | SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis |
| Q24293735 | Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis |
| Q41520294 | Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate |
| Q35665655 | Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development |
| Q33627269 | Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation |
| Q42130842 | Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients |
| Q24669877 | Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta |
| Q97549764 | Short high-fat diet interferes with the physiological maturation of the late adolescent mouse heart |
| Q42044656 | Short-term akt activation in cardiac muscle cells improves contractile function in failing hearts. |
| Q33775212 | Signaling specificity in the Akt pathway in biology and disease |
| Q38252278 | Signalling specificity in the Akt pathway in breast cancer |
| Q39286426 | Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis |
| Q33655562 | Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis |
| Q52921010 | Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. |
| Q34234931 | Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons |
| Q37427465 | Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA. |
| Q47160893 | Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. |
| Q43268934 | Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1. |
| Q36588130 | Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling |
| Q36573021 | Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice |
| Q28509136 | Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis |
| Q40346793 | Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus |
| Q29568312 | Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway |
| Q24297375 | Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2 |
| Q34289268 | TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation |
| Q35803790 | TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages |
| Q29617473 | Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression |
| Q37497352 | Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development |
| Q37872655 | Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs |
| Q34116730 | The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane |
| Q38472472 | The Akt isoforms, their unique functions and potential as anticancer therapeutic targets |
| Q37549798 | The Akt kinases: isoform specificity in metabolism and cancer |
| Q36313193 | The Akt/PKB pathway: molecular target for cancer drug discovery |
| Q37294231 | The Akt1 isoform is an essential mediator of ischaemic preconditioning |
| Q36572565 | The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo |
| Q34556111 | The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling |
| Q28610410 | The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 |
| Q33327777 | The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation |
| Q33770769 | The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors |
| Q34432494 | The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo |
| Q34766011 | The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. |
| Q34825957 | The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network |
| Q36402605 | The Pim kinases control rapamycin-resistant T cell survival and activation |
| Q38121538 | The Role of PTEN in β-Cell Growth. |
| Q34560188 | The WNKs: atypical protein kinases with pleiotropic actions. |
| Q34328370 | The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. |
| Q59282167 | The anti-apoptotic role of PPARβ contributes to efficient skin wound healing |
| Q36752770 | The beginning of the end: death signaling in early involution |
| Q28083829 | The critical role of Akt in cardiovascular function |
| Q37300974 | The cullin7 E3 ubiquitin ligase: a novel player in growth control |
| Q36527188 | The eIF4E RNA regulon promotes the Akt signaling pathway |
| Q35738371 | The effect Akt2 deletion on tumor development in Pten(+/-) mice. |
| Q37151504 | The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription |
| Q33848265 | The ontogeny of insulin signaling in the preterm baboon model |
| Q36745379 | The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer |
| Q29547860 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer |
| Q37087125 | The potential roles for embryotrophic ligands in preimplantation embryo development |
| Q35844958 | The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. |
| Q37954130 | The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes. |
| Q39530992 | The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo |
| Q92830497 | The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis |
| Q38175044 | The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development |
| Q41600042 | The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion |
| Q34286691 | Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation |
| Q36289784 | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway |
| Q64374842 | Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R |
| Q44617813 | Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases |
| Q36772120 | Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis |
| Q34801542 | Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. |
| Q35958600 | Update on diagnosis, pathogenesis and management of ketosis-prone Type 2 diabetes mellitus |
| Q30925087 | Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions |
| Q24318997 | VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase |
| Q47771376 | Variation in Akt protein kinases in human populations. |
| Q27315945 | Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice |
| Q53051512 | Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent. |
| Q54324870 | [Control of insulin signalisation and action by the Grb14 protein]. |
| Q34800160 | mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. |
| Q28252695 | mTOR signaling in tumorigenesis |
| Q24647655 | mTOR signaling: at the crossroads of plasticity, memory and disease |
| Q26864688 | mTOR-dependent cell survival mechanisms |
| Q36827582 | mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system |
| Q51417912 | miR-25-3p, Positively Regulated by Transcription Factor AP-2α, Regulates the Metabolism of C2C12 Cells by Targeting Akt1. |
| Q38960051 | miR-99a suppresses the metastasis of human non-small cell lung cancer cells by targeting AKT1 signaling pathway |
| Q24295160 | siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle |
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