AKT2 is essential to maintain podocyte viability and function during chronic kidney disease

scientific article published on 22 September 2013

AKT2 is essential to maintain podocyte viability and function during chronic kidney disease is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046808338
P356DOI10.1038/NM.3313
P698PubMed publication ID24056770

P50authorAndrea Onetti MudaQ56428257
Frank BienaiméQ56959308
Gérard FriedlanderQ39659602
P2093author name stringTobias B Huber
Mario Pende
Andrea Onetti Muda
Fabiola Terzi
Marco Pontoglio
Christophe Legendre
Konstantinos Giannakakis
Guillaume Canaud
Amandine Viau
Stefan Zschiedrich
Clément Nguyen
Caroline Treins
Sophie Berissi
Martine Burtin
William Baron
P2860cites workRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaQ24669877
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in miceQ43726502
Sirolimus interacts with pathways essential for podocyte integrityQ45151652
Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy.Q46510650
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasisQ46522437
Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approachQ46616535
The Notch pathway in podocytes plays a role in the development of glomerular diseaseQ46725170
Proteinuria following a switch from calcineurin inhibitors to sirolimusQ46825307
Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.Q46886156
The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin.Q51547435
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Signaling in regulation of podocyte phenotypes.Q54774137
Podocyte-specific expression of cre recombinase in transgenic miceQ57740867
Mammalian Target of Rapamycin Inhibition Halts the Progression of Proteinuria in a Rat Model of Reduced Renal MassQ59531350
Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell MigrationQ60155829
Age-associated changes in renal glomeruli of miceQ69627600
Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosisQ80433109
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Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell deathQ81007653
Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysisQ26995926
Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndromeQ28256662
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Proliferation and remodeling of the peritubular microcirculation after nephron reduction: association with the progression of renal lesionsQ28345280
Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosisQ28504659
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signalingQ28611533
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Role of mTOR in podocyte function and diabetic nephropathy in humans and miceQ30500731
Long-term benefits with sirolimus-based therapy after early cyclosporine withdrawalQ33359653
Induction of B7-1 in podocytes is associated with nephrotic syndromeQ33785088
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.Q33943247
Proteinuria: an enzymatic disease of the podocyte?Q33943310
Lipocalin 2 is essential for chronic kidney disease progression in mice and humansQ34245315
TGF-alpha mediates genetic susceptibility to chronic kidney disease.Q34534909
Hyperfiltration and glomerulosclerosisQ35110865
Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injuryQ35126310
Inhibition of podocyte FAK protects against proteinuria and foot process effacement.Q35153198
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytesQ35916016
Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT.Q35937270
Pathways to nephron loss starting from glomerular diseases-insights from animal modelsQ36021181
Podocyte-specific loss of Cdc42 leads to congenital nephropathyQ36050935
The podocyte's response to injury: role in proteinuria and glomerulosclerosisQ36474870
Podocytes in culture: past, present, and futureQ36801026
Actin up: regulation of podocyte structure and function by components of the actin cytoskeletonQ36931220
The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitorsQ37089913
Intracellular signaling by Akt: bound to be specificQ37193392
Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuriaQ37330532
Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes.Q39719517
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney diseaseQ39912709
mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytesQ39914641
Banff 07 classification of renal allograft pathology: updates and future directionsQ40121163
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinaseQ40533718
Progression of renal disease and renal hypertrophyQ40543219
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrinQ40545315
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in miceQ41912848
Insulin signaling to the glomerular podocyte is critical for normal kidney functionQ42110064
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1Q42592859
P433issue10
P921main subjectchronic renal insufficiencyQ736715
P304page(s)1288-1296
P577publication date2013-09-22
P1433published inNature MedicineQ1633234
P1476titleAKT2 is essential to maintain podocyte viability and function during chronic kidney disease
P478volume19