| scholarly article | Q13442814 |
| P50 | author | C. Ronald Kahn | Q16106681 |
| Morris J. Birnbaum | Q40173515 | ||
| Kohjiro Ueki | Q65013004 | ||
| P2093 | author name string | Sully Fernandez | |
| Rexford S Ahima | |||
| Bobby R Monks | |||
| Qingwei Chu | |||
| Min Wan | |||
| Mingjian Lu | |||
| Karla F Leavens | |||
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| Insulin signalling and the regulation of glucose and lipid metabolism | Q24292020 | ||
| The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription | Q24301955 | ||
| SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth | Q24309283 | ||
| Forkhead transcription factors and ageing | Q37129813 | ||
| The Extending Network of FOXO Transcriptional Target Genes | Q37776729 | ||
| Akt2 is required for hepatic lipid accumulation in models of insulin resistance. | Q38349186 | ||
| Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity | Q40313842 | ||
| Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c | Q40507727 | ||
| Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity | Q40649584 | ||
| Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. | Q40667994 | ||
| Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes | Q42812120 | ||
| Hypothalamic insulin signaling is required for inhibition of glucose production | Q44212603 | ||
| Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. | Q46297094 | ||
| Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes | Q46884440 | ||
| FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression | Q46955933 | ||
| Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway | Q47960215 | ||
| A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding | Q48322350 | ||
| Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver | Q48386175 | ||
| Role of hepatic STAT3 in brain-insulin action on hepatic glucose production | Q48596967 | ||
| Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. | Q51495612 | ||
| Foxa2 integrates the transcriptional response of the hepatocyte to fasting. | Q51512450 | ||
| Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction | Q74191142 | ||
| Insulin signaling in health and disease | Q79347099 | ||
| Identification of a proline-rich Akt substrate as a 14-3-3 binding partner | Q24338582 | ||
| Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion | Q24536290 | ||
| Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility | Q24594995 | ||
| A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange | Q24648525 | ||
| TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 | ||
| SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity | Q28262782 | ||
| Stressing the role of FoxO proteins in lifespan and disease | Q28303730 | ||
| Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene | Q28349476 | ||
| Role for Akt3/protein kinase Bgamma in attainment of normal brain size | Q28509294 | ||
| Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice | Q28511006 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B | Q28638147 | ||
| Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress | Q29614493 | ||
| Critical nodes in signalling pathways: insights into insulin action | Q29614735 | ||
| Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 | Q29617416 | ||
| Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction | Q29619822 | ||
| O-GlcNAc regulates FoxO activation in response to glucose | Q30439420 | ||
| mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. | Q33734395 | ||
| Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis | Q33734679 | ||
| Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage | Q33750671 | ||
| Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation | Q33755125 | ||
| Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action | Q33768316 | ||
| PDK1 regulates growth through Akt and S6K in Drosophila | Q33952857 | ||
| Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation | Q34089899 | ||
| FoxOs function synergistically to promote glucose production | Q34284954 | ||
| Insulin-regulated gene expression | Q34332489 | ||
| Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models | Q34514818 | ||
| Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism | Q34945194 | ||
| Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling | Q35015752 | ||
| dFOXO-independent effects of reduced insulin-like signaling in Drosophila | Q35347460 | ||
| FoxOs at the crossroads of cellular metabolism, differentiation, and transformation | Q35770614 | ||
| Selective versus total insulin resistance: a pathogenic paradox | Q37076798 | ||
| FOXO-binding partners: it takes two to tango | Q37129794 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 388-395 | |
| P577 | publication date | 2012-02-19 | |
| P1433 | published in | Nature Medicine | Q1633234 |
| P1476 | title | Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 | |
| P478 | volume | 18 |
| Q36567950 | A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver |
| Q35630807 | A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism |
| Q43071713 | A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition |
| Q36312583 | A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia |
| Q37255010 | A renaissance in medical biochemistry - Hepatology and Endocrinology kick it up a Notch! |
| Q39255027 | AKT/PKB Signaling: Navigating the Network |
| Q85964497 | AKT2 is essential to maintain podocyte viability and function during chronic kidney disease |
| Q51068463 | Ablation of insulin-producing cells prevents obesity but not premature mortality caused by a high-sugar diet in Drosophila. |
| Q36383068 | Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance |
| Q37525730 | Akt-mediated foxo1 inhibition is required for liver regeneration. |
| Q38194549 | Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes |
| Q38824980 | Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells |
| Q57244014 | Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level |
| Q89595472 | An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance |
| Q90198999 | Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver |
| Q35657226 | Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. |
| Q49227150 | Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice |
| Q38318620 | Autonomic regulation of hepatic glucose production. |
| Q47414450 | BRD7 regulates the insulin-signaling pathway by increasing phosphorylation of GSK3β. |
| Q64040124 | Brown fat organogenesis and maintenance requires AKT1 and AKT2 |
| Q47563328 | Central IGF1 improves glucose tolerance and insulin sensitivity in mice |
| Q37079786 | Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents |
| Q34314990 | Control of hepatic glucose metabolism by islet and brain. |
| Q37698362 | Cooperation between brain and islet in glucose homeostasis and diabetes |
| Q51118064 | Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle. |
| Q55084839 | Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling. |
| Q35688145 | Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production |
| Q47976670 | DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. |
| Q47108817 | Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice |
| Q36672871 | Diabetic cardiomyopathy and metabolic remodeling of the heart |
| Q28114796 | Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes |
| Q90918133 | Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish |
| Q37008856 | Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production |
| Q36497258 | Direct control of hepatic glucose production by interleukin-13 in mice. |
| Q41160745 | Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins |
| Q33828131 | Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity |
| Q26996783 | Energy metabolism in the liver |
| Q45875460 | Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout |
| Q34491594 | Exercise, energy intake, glucose homeostasis, and the brain |
| Q90460739 | FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme |
| Q39385262 | FOXO transcription factors at the interface of metabolism and cancer |
| Q37704641 | FOXO transcription factors protect against the diet-induced fatty liver disease |
| Q34486726 | FOXO1 content is reduced in cystic fibrosis and increases with IGF-I treatment |
| Q38074598 | FOXOs: signalling integrators for homeostasis maintenance |
| Q37613511 | Fatty acid-regulated transcription factors in the liver |
| Q35338937 | Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis |
| Q35860656 | Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice. |
| Q38121578 | Forkhead box class O transcription factors in liver function and disease |
| Q50163221 | FoxO transcription factors are required for hepatic HDL-cholesterol clearance |
| Q37143203 | FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes |
| Q36584799 | FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization |
| Q47209799 | FoxO1 is required for most of the metabolic and hormonal perturbations produced by hepatic insulin receptor deletion in male mice |
| Q90458257 | Free fatty acid processing diverges in human pathologic insulin resistance conditions |
| Q39414496 | From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions |
| Q54383388 | GdCl3 reduces hyperglycaemia through Akt/FoxO1-induced suppression of hepatic gluconeogenesis in Type 2 diabetic mice. |
| Q97519952 | Genetic determinants of obesity heterogeneity in type II diabetes |
| Q48223878 | Genistein represses PEPCK-C expression in an insulin-independent manner in HepG2 cells and in alloxan-induced diabetic mice. |
| Q47139797 | Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction |
| Q28507540 | Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects |
| Q37311340 | Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver |
| Q35029601 | Gut-brain mechanisms controlling glucose homeostasis |
| Q47096026 | Hepatic Dysfunction Caused by Consumption of a High-Fat Diet. |
| Q36283518 | Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. |
| Q51281687 | Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. |
| Q35837720 | Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes |
| Q35601144 | Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo |
| Q35104088 | Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2 |
| Q42249714 | Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1. |
| Q92975834 | High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network |
| Q34551996 | High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance |
| Q38540380 | Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma. |
| Q38765909 | Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis |
| Q34286779 | Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2 |
| Q88985855 | Inactivating hepatic follistatin alleviates hyperglycemia |
| Q36477267 | Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin |
| Q57163286 | Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture |
| Q36518326 | Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein |
| Q26823171 | Insulin receptor signaling in normal and insulin-resistant states |
| Q50226931 | Insulin regulation of gluconeogenesis |
| Q26865988 | Insulin resistance in clinical and experimental alcoholic liver disease |
| Q60907115 | Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver |
| Q33865096 | Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms |
| Q36342908 | Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase |
| Q34339449 | Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. |
| Q37677992 | Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress. |
| Q89051847 | Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice |
| Q55418554 | Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis. |
| Q58751483 | Lack of 17β-estradiol reduces sensitivity to insulin in the liver and muscle of male mice |
| Q36339341 | Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction |
| Q39394066 | Liver-specific G0 /G1 switch gene 2 (G0s2) expression promotes hepatic insulin resistance by exacerbating hepatic steatosis in male Wistar rats |
| Q35598541 | Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity. |
| Q55162298 | MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells. |
| Q35515702 | Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism |
| Q90232623 | Maintenance of liver glycogen during long-term fasting preserves energy state in mice |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q83576754 | Metabolism: an Akt-independent pathway for regulation of gluconeogenesis |
| Q60950122 | MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes |
| Q38628354 | Molecular pathophysiology of hepatic glucose production |
| Q64957324 | Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. |
| Q52728579 | Myeloid-Specific Deletion of Zfp36 Protects Against Insulin Resistance and Fatty Liver in Diet-Induced Obese Mice. |
| Q38978347 | NAFLD and diabetes mellitus |
| Q38859044 | Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? |
| Q38706187 | Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes |
| Q48010558 | Oral leptin supplementation throughout lactation in rats prevents later metabolic alterations caused by gestational calorie restriction |
| Q64084543 | P110β in the ventromedial hypothalamus regulates glucose and energy metabolism |
| Q92864499 | PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms |
| Q40810931 | PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling |
| Q54323656 | PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis. |
| Q42870991 | PP2A inhibition results in hepatic insulin resistance despite Akt2 activation |
| Q33825128 | PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity |
| Q35662330 | Pathogenesis of selective insulin resistance in isolated hepatocytes |
| Q42637631 | Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism |
| Q38110890 | Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis. |
| Q27022953 | Phosphoinositides: Key modulators of energy metabolism |
| Q58758462 | Phosphorylation-Dependent Inhibition of Akt1 |
| Q61448833 | Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues |
| Q89370262 | Quantitative path to deep phenotyping: Possible importance of reduced hepatic insulin degradation to type 2 diabetes mellitus pathogenesis |
| Q44870674 | Red Blood Cells for Glucose-Responsive Insulin Delivery |
| Q89873336 | Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2 |
| Q39450184 | Regulation of hepatic glucose metabolism in health and disease |
| Q59793634 | Repression of Transcriptional Activity of Forkhead Box O1 by Histone Deacetylase Inhibitors Ameliorates Hyperglycemia in Type 2 Diabetic Rats |
| Q64916831 | Resolving the Paradox of Hepatic Insulin Resistance. |
| Q37099495 | SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding |
| Q47620022 | Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling |
| Q28513222 | Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling |
| Q92099163 | Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells |
| Q37038522 | Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. |
| Q27318316 | TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans |
| Q28589957 | TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver |
| Q64076904 | Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery |
| Q42360606 | The AKTion in non-canonical insulin signaling |
| Q58798256 | The PI3K/AKT pathway in obesity and type 2 diabetes |
| Q60919420 | The Roles of Mitochondrial SIRT4 in Cellular Metabolism |
| Q36277292 | The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet |
| Q91698411 | The integrative biology of type 2 diabetes |
| Q91812871 | The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans |
| Q36113537 | The new biology of diabetes |
| Q36430696 | The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux |
| Q38247935 | The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents. |
| Q92830497 | The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis |
| Q42233703 | The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice |
| Q34076176 | Tissue-specific insulin signaling in the regulation of metabolism and aging |
| Q61810256 | Unraveling the Regulation of Hepatic Gluconeogenesis |
| Q39246859 | Unraveling the Regulation of Hepatic Metabolism by Insulin |
| Q33808145 | Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass |
| Q42335512 | kNOXing on the door of selective insulin resistance |
| Q39641749 | mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. |
| Q36511172 | mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. |
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