| scholarly article | Q13442814 |
| P50 | author | C. Ronald Kahn | Q16106681 |
| P2093 | author name string | J. Boucher | |
| A. Kleinridders | |||
| P2860 | cites work | Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances | Q21131281 |
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| CAP defines a second signalling pathway required for insulin-stimulated glucose transport | Q24290287 | ||
| TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism | Q24294579 | ||
| Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex | Q24295120 | ||
| siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle | Q24295160 | ||
| Second AKT: the rise of SGK in cancer signalling | Q24301817 | ||
| Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101) | Q24303870 | ||
| TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver | Q24304147 | ||
| Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 | Q24304774 | ||
| A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 | ||
| Insulin receptor-related receptor as an extracellular alkali sensor | Q24305466 | ||
| S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2 | Q24309036 | ||
| Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 | ||
| A role of DNA-PK for the metabolic gene regulation in response to insulin | Q24323112 | ||
| A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family | Q24323752 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase | Q24531326 | ||
| Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice | Q24552910 | ||
| Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse | Q24564225 | ||
| Toll-like receptor signalling | Q24570126 | ||
| PHLiPPing the switch on Akt and protein kinase C signaling | Q24625894 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| AKT/PKB signaling: navigating downstream | Q24657857 | ||
| Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action | Q24803901 | ||
| Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism | Q27667112 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein | Q28116980 | ||
| The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307) | Q28139056 | ||
| Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta | Q28188643 | ||
| Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action | Q28199220 | ||
| SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 | Q28201656 | ||
| Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes | Q28202364 | ||
| Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B | Q28208638 | ||
| Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance | Q28253498 | ||
| Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity | Q28255760 | ||
| The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family | Q48050897 | ||
| Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes. | Q51481490 | ||
| Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly. | Q51559703 | ||
| Amplification and analysis of promoter region of insulin receptor gene in a patient with leprechaunism associated with severe insulin resistance. | Q52209409 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. | Q52537778 | ||
| Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. | Q52540333 | ||
| Phosphorylation of purified insulin receptor by cAMP kinase. | Q54415183 | ||
| Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor. | Q55054153 | ||
| Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals | Q57714278 | ||
| A Replication Study of the IRS1, CAPN10, TCF7L2, and PPARG Gene Polymorphisms Associated with Type 2 Diabetes in Two Different Populations of Mexico | Q57732779 | ||
| Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle | Q58451071 | ||
| Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women | Q59150847 | ||
| Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity | Q64377000 | ||
| Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor | Q68955316 | ||
| Ceramide activates the stress-activated protein kinases | Q71742988 | ||
| Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia | Q72150727 | ||
| Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats | Q77952724 | ||
| Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle | Q78060389 | ||
| Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling | Q78074895 | ||
| Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes | Q81052868 | ||
| Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregn | Q42489803 | ||
| Irs1 serine 307 promotes insulin sensitivity in mice | Q42563623 | ||
| Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 | Q42592859 | ||
| Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects | Q42797512 | ||
| SOCS-3 is an insulin-induced negative regulator of insulin signaling | Q42801701 | ||
| Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport | Q42802836 | ||
| A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. | Q42803390 | ||
| Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes | Q42826146 | ||
| Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C. | Q42833336 | ||
| Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. | Q42924282 | ||
| Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity | Q42984934 | ||
| Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study. | Q43283816 | ||
| Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state | Q43778796 | ||
| Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle | Q43990155 | ||
| Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism | Q44582556 | ||
| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. | Q44859720 | ||
| The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies | Q44946396 | ||
| Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies | Q45067792 | ||
| Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy | Q45200908 | ||
| Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades. | Q45308583 | ||
| Endoplasmic reticulum stress plays a central role in development of leptin resistance | Q46178586 | ||
| Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus | Q46493853 | ||
| Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. | Q46549798 | ||
| Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase | Q46655143 | ||
| Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients | Q46801587 | ||
| Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3. | Q46843515 | ||
| Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice | Q46881275 | ||
| Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases | Q48021665 | ||
| Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians | Q48033165 | ||
| Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene | Q48043417 | ||
| Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5 | Q34194701 | ||
| The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society | Q34292435 | ||
| Lipid-induced insulin resistance: unravelling the mechanism | Q34370958 | ||
| Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions | Q34527799 | ||
| Hexosamines as mediators of nutrient sensing and regulation in diabetes. | Q34548619 | ||
| Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression | Q34563098 | ||
| The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. | Q34656644 | ||
| Functionally distinct insulin receptors generated by tissue-specific alternative splicing | Q34734673 | ||
| Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic | Q34778453 | ||
| The PTEN-PI3K pathway: of feedbacks and cross-talks | Q34828662 | ||
| Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. | Q34882666 | ||
| Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. | Q35002762 | ||
| Adipose tissue remodeling and obesity | Q35015740 | ||
| PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans | Q35015769 | ||
| The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer | Q35124588 | ||
| Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation | Q35131032 | ||
| Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α | Q35161212 | ||
| A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. | Q35285121 | ||
| Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling | Q35370616 | ||
| The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling | Q35479152 | ||
| From PDE3B to the regulation of energy homeostasis | Q35577583 | ||
| Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle | Q35665651 | ||
| Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome | Q35752347 | ||
| Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. | Q35785726 | ||
| Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice | Q35805369 | ||
| mTOR complex 2 signaling and functions | Q35878519 | ||
| Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes | Q35879528 | ||
| Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life | Q35950176 | ||
| The use of U-500 in patients with extreme insulin resistance | Q36108415 | ||
| Grb10 and Grb14: enigmatic regulators of insulin action--and more? | Q36131371 | ||
| Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo | Q36177520 | ||
| The molecular basis for oxidative stress-induced insulin resistance | Q36184182 | ||
| FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases | Q36300077 | ||
| Reactive species and early manifestation of insulin resistance in type 2 diabetes | Q36382700 | ||
| The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy | Q28269098 | ||
| Regulation of cell death protease caspase-9 by phosphorylation | Q28288607 | ||
| Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance | Q28291556 | ||
| Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4 | Q28343432 | ||
| Prevention of fat-induced insulin resistance by salicylate | Q28345600 | ||
| Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit | Q28379354 | ||
| The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins | Q28507365 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt | Q28511947 | ||
| Testis determination requires insulin receptor family function in mice | Q28512518 | ||
| Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease | Q28571421 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity | Q28582308 | ||
| The lipid phosphatase SHIP2 controls insulin sensitivity | Q28584843 | ||
| Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms | Q28586863 | ||
| Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase | Q28589116 | ||
| Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity | Q28590308 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity | Q29614283 | ||
| Critical nodes in signalling pathways: insights into insulin action | Q29614735 | ||
| Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| The nuts and bolts of AGC protein kinases | Q29617465 | ||
| TLR4 links innate immunity and fatty acid-induced insulin resistance | Q29617577 | ||
| Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene | Q29618933 | ||
| A central role for JNK in obesity and insulin resistance | Q29619778 | ||
| CCR2 modulates inflammatory and metabolic effects of high-fat feeding | Q29622869 | ||
| Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase | Q30156937 | ||
| O-GlcNAc regulates FoxO activation in response to glucose | Q30439420 | ||
| Activation of SOCS-3 by resistin | Q30856129 | ||
| Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. | Q30875462 | ||
| Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. | Q31527752 | ||
| Regulation of protein kinase cascades by protein phosphatase 2A. | Q33632946 | ||
| Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation | Q33648347 | ||
| Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling | Q33688611 | ||
| Tlr2 is critical for diet-induced metabolic syndrome in a murine model. | Q33694600 | ||
| Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue | Q33707592 | ||
| Muscle-specific Pten deletion protects against insulin resistance and diabetes | Q33714209 | ||
| PTEN mutations as a cause of constitutive insulin sensitivity and obesity. | Q33811688 | ||
| Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. | Q33858986 | ||
| TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle. | Q33869742 | ||
| Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription | Q33883451 | ||
| Radicals and oxidative stress in diabetes | Q33900538 | ||
| The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. | Q33928657 | ||
| Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade | Q33942025 | ||
| The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. | Q33942082 | ||
| Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance | Q33945264 | ||
| Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation | Q33967843 | ||
| Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance | Q33997240 | ||
| Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha | Q34012425 | ||
| Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia | Q34075585 | ||
| Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice | Q34107651 | ||
| Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. | Q34168448 | ||
| The role of protein phosphatase-1 in insulin action | Q34174108 | ||
| Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity | Q34181503 | ||
| Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation | Q34183649 | ||
| A family with severe insulin resistance and diabetes due to a mutation in AKT2. | Q36481707 | ||
| Regulating insulin signaling and beta-cell function through IRS proteins | Q36602630 | ||
| Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected] | Q36604703 | ||
| Insulin sensitivity: modulation by nutrients and inflammation | Q36848937 | ||
| Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance. | Q36901837 | ||
| Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects | Q36906306 | ||
| Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity | Q36981204 | ||
| Intracellular fatty acid metabolism in skeletal muscle and insulin resistance | Q37065586 | ||
| Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance | Q37066869 | ||
| The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes | Q37072688 | ||
| The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2. | Q37113882 | ||
| Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity | Q37141748 | ||
| In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs. | Q37142827 | ||
| Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes | Q37166661 | ||
| Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status | Q37174783 | ||
| A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. | Q37224233 | ||
| Phosphorylation of IRS proteins, insulin action, and insulin resistance | Q37252616 | ||
| IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85 | Q37276745 | ||
| Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis | Q37332419 | ||
| A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies | Q37355784 | ||
| Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis | Q37360125 | ||
| Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity | Q37393990 | ||
| Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt | Q37399825 | ||
| MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity | Q37502701 | ||
| SHIP2 and its involvement in various diseases | Q37763949 | ||
| PDK1: the major transducer of PI 3-kinase actions | Q37766484 | ||
| Insulin says NO to cardiovascular disease | Q37807194 | ||
| Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance. | Q37822940 | ||
| Promiscuous affairs of PKB/AKT isoforms in metabolism. | Q37826755 | ||
| FoxO transcription factors; Regulation by AKT and 14-3-3 proteins | Q37894891 | ||
| Structural basis for activation and inhibition of class I phosphoinositide 3-kinases | Q37947094 | ||
| The cellular and signaling networks linking the immune system and metabolism in disease | Q37991199 | ||
| Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: potential mechanisms and functional consequences | Q38009969 | ||
| Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region | Q38293205 | ||
| SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice | Q38295719 | ||
| Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin | Q38326247 | ||
| Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. | Q38342426 | ||
| Increased adipose tissue expression of Grb14 in several models of insulin resistance | Q38342920 | ||
| Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle | Q39556161 | ||
| Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. | Q39565163 | ||
| Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. | Q39646969 | ||
| Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | Q39940319 | ||
| PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival | Q39987929 | ||
| PKC-theta knockout mice are protected from fat-induced insulin resistance | Q39989111 | ||
| Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. | Q40122836 | ||
| Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species | Q40286562 | ||
| Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. | Q40447329 | ||
| Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c | Q40507727 | ||
| Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer. | Q40530643 | ||
| Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells | Q40546613 | ||
| Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils | Q40591759 | ||
| Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese population | Q40615998 | ||
| Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. | Q40701074 | ||
| The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change | Q40761363 | ||
| HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation | Q40767550 | ||
| Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | Q40816506 | ||
| Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene | Q40968948 | ||
| Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase | Q41019400 | ||
| Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance | Q41179543 | ||
| Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression | Q41862754 | ||
| Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation | Q41909279 | ||
| Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion. | Q41910421 | ||
| Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain | Q42053859 | ||
| Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. | Q42123948 | ||
| Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting | Q42139574 | ||
| Insulin resistance in normal rats infused with glucose for 72 h. | Q42472533 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| preproinsulin | Q7240673 | ||
| P577 | publication date | 2014-01-01 | |
| P1433 | published in | Cold Spring Harbor Perspectives in Biology | Q3927509 |
| P1476 | title | Insulin receptor signaling in normal and insulin-resistant states | |
| P478 | volume | 6 |
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| Q48132740 | Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice |
| Q41993635 | Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids. |
| Q58702026 | Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling |
| Q64067839 | Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling |
| Q43373010 | Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy. |
| Q54978857 | Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage. |
| Q37676392 | Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes |
| Q55353865 | Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits. |
| Q90346223 | Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats |
| Q42362671 | Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation |
| Q53682462 | Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis. |
| Q96304934 | BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer |
| Q94606183 | Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity |
| Q47703395 | Biochemical and cellular properties of insulin receptor signalling |
| Q58697764 | CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling |
| Q57476078 | CEACAM1 in Liver Injury, Metabolic and Immune Regulation |
| Q36699832 | Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats |
| Q45418195 | Chinese Olive (Canarium album L.) Fruit Extract Attenuates Metabolic Dysfunction in Diabetic Rats |
| Q58699775 | Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice |
| Q64949376 | Chronic synaptic insulin resistance after traumatic brain injury abolishes insulin protection from amyloid beta and tau oligomer-induced synaptic dysfunction. |
| Q37743789 | Circadian Control of Cardiac Metabolism: Physiologic Roles and Pathologic Implications |
| Q92535821 | Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway |
| Q64125156 | Computation and application of tissue-specific gene set weights |
| Q39193265 | Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors |
| Q55040593 | Current applications of antibody microarrays. |
| Q37456221 | Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling. |
| Q94540673 | Design and Synthesis of a Library of Thiazolidin-4-one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt to Discover Novel Anti-diabetic Agents |
| Q36159631 | Development of a new model system to dissect isoform specific Akt signalling in adipocytes |
| Q52658260 | Diabetic neuropathy and the sensory neuron: New aspects of pathogenesis and their treatment implications. |
| Q47118580 | Dietary Anthocyanins and Insulin Resistance: When Food Becomes a Medicine |
| Q64116849 | Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance) |
| Q64928530 | Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. |
| Q33808884 | Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets. |
| Q58729926 | Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation |
| Q46134650 | Dnmt3a is an epigenetic mediator of adipose insulin resistance. |
| Q128772941 | Does Pre-existing Diabetes Correlate with Long COVID-19 in Europe? Evidence from the Analysis of the Survey of Health, Ageing and Retirement in Europe’s Corona Surveys |
| Q61433479 | Duodenal-Jejunal Bypass Restores Insulin Action and Βeta-Cell Function in Hypothalamic-Obese Rats |
| Q36106341 | E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte |
| Q64283857 | E4orf1 protein reduces the need for endogenous insulin |
| Q60046258 | E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling |
| Q36109894 | Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population |
| Q57161221 | Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions |
| Q89819928 | Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes |
| Q39281006 | Effect of High Glucose Levels on White Adipose Cells and Adipokines-Fuel for the Fire |
| Q94596444 | Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review |
| Q99614370 | Effect of growth hormone on insulin signaling |
| Q64080316 | Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling |
| Q91727269 | Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models |
| Q90264149 | Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach |
| Q64275690 | Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review |
| Q38980163 | Epigenomic and transcriptional control of insulin resistance |
| Q38645263 | Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1 in type 2 diabetic rats |
| Q43450920 | Establishment and phenotyping of disease model cells created by cell-resealing technique |
| Q46303091 | Estradiol Protects Proopiomelanocortin Neurons against Insulin Resistance. |
| Q91142496 | Evolving concepts in the pathogenesis of uraemic cardiomyopathy |
| Q53661039 | Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation. |
| Q37300966 | Exercise Promotes Healthy Aging of Skeletal Muscle |
| Q48130979 | Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis. |
| Q36955992 | Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health |
| Q64073513 | FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism |
| Q47176848 | Gene expression of insulin receptor, insulin-like growth factor increases and insulin-like growth factor-binding protein-3 reduces with increase in prostate size in benign prostatic hyperplasia |
| Q58763780 | Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells |
| Q38836995 | Glycogen phosphorylase inhibition improves beta cell function. |
| Q64104722 | Glycyrrhetinic Acid Improves Insulin-Response Pathway by Regulating the Balance between the Ras/MAPK and PI3K/Akt Pathways |
| Q53697244 | Green tea extracts ameliorate high-fat diet-induced muscle atrophy in senescence-accelerated mouse prone-8 mice. |
| Q38725973 | Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma |
| Q64971617 | H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK. |
| Q58544185 | Heat Shock Proteins as a Potential Therapeutic Target in the Treatment of Gestational Diabetes Mellitus: What We Know so Far |
| Q50031898 | Hepatic Gi signaling regulates whole-body glucose homeostasis. |
| Q39354254 | High-Fat Diet and Female Fertility. |
| Q61818543 | Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease |
| Q90339790 | Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes |
| Q45974242 | Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. |
| Q38540380 | Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma. |
| Q99248451 | Hyperinsulinaemia in cancer |
| Q93140216 | IGF-1R/β-catenin signaling axis is involved in type 2 diabetic osteoporosis |
| Q93065431 | IR-A/IGF-1R-mediated signals promote epithelial-mesenchymal transition of endometrial carcinoma cells by activating PI3K/AKT and ERK pathways |
| Q90005499 | Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior |
| Q64934586 | Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. |
| Q38757112 | Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/--IRS-1+/- Double Heterozygous (IR-IRS1dh) Mice |
| Q55045285 | Increased IRS2 mRNA Expression in SGA Neonates: PCR Analysis of Insulin/IGF Signaling in Cord Blood. |
| Q35685582 | Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues |
| Q89882460 | Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction |
| Q38437282 | Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis |
| Q92905171 | Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression |
| Q63805071 | Insulin Resistance and Oxidative Stress in the Brain: What's New? |
| Q30377910 | Insulin Signaling and Heart Failure. |
| Q53733290 | Insulin action and resistance in obesity and type 2 diabetes. |
| Q64246566 | Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain |
| Q48056892 | Insulin action in the brain: Roles in energy and glucose homeostasis |
| Q34407440 | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes |
| Q92294435 | Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series |
| Q91260434 | Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2 |
| Q55385002 | Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats. |
| Q39408469 | Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells |
| Q55385323 | Insulin receptor based lymphocyte trafficking in the progression of type 1 diabetes. |
| Q96640282 | Insulin receptor endocytosis in the pathophysiology of insulin resistance |
| Q57453189 | Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly |
| Q93000749 | Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses |
| Q88576256 | Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers |
| Q38762602 | Insulin supersensitivity and normoinsulinaemic hypoglycaemia in uncontrolled type 2 diabetes mellitus: clinical usefulness of 3 h assessment in the 75 g oral glucose tolerance test |
| Q89771857 | Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation |
| Q46306015 | Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. |
| Q91582694 | Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes |
| Q89293086 | Insulin/IGF-1 enhances intestinal epithelial crypt proliferation through PI3K/Akt, and not ERK signaling in obese humans |
| Q50314975 | Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer |
| Q90161695 | Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus |
| Q91329734 | Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells |
| Q45305677 | Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis |
| Q28075486 | Is REDD1 a Metabolic Éminence Grise? |
| Q41622753 | Latent Inflammation and Insulin Resistance in Adipose Tissue |
| Q97643671 | Leptin and the endocrine control of energy balance |
| Q41661857 | Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice. |
| Q39033981 | Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging |
| Q37702659 | Linking maternal obesity to early insulin resistance |
| Q58781043 | Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia |
| Q91906211 | Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway |
| Q50115832 | Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. |
| Q37237315 | MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. |
| Q30235587 | Macrophage function in obesity-induced inflammation and insulin resistance. |
| Q60915852 | Maternal Cognitive Impairment Associated with Gestational Diabetes Mellitus-A Review of Potential Contributing Mechanisms |
| Q55412238 | Mechanisms Underlying the Synergistic Action of Insulin and Growth Hormone on IGF-I and -II Expression in Grass Carp Hepatocytes. |
| Q36751833 | Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise |
| Q90685522 | Mechanisms of Insulin Action and Insulin Resistance |
| Q90378285 | Mechanisms of insulin resistance related to white, beige, and brown adipocytes |
| Q37569276 | Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment |
| Q48269656 | Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats. |
| Q90191397 | Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity |
| Q47398853 | Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs |
| Q55283805 | Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism? |
| Q41440478 | Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis |
| Q64096256 | Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling |
| Q47165661 | Molecular Mechanisms of Antipsychotic Drug-Induced Diabetes |
| Q28395675 | Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes |
| Q48157286 | Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome |
| Q33851783 | Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction. |
| Q64957324 | Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. |
| Q34620390 | Munc18c: a controversial regulator of peripheral insulin action |
| Q33813770 | Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins |
| Q58773148 | Muscle Loss in Chronic Liver Diseases: The Example of Nonalcoholic Liver Disease |
| Q36607500 | Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance |
| Q64079947 | NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice |
| Q88582817 | NRF2 and the Hallmarks of Cancer |
| Q36835116 | Nuclear Mechanisms of Insulin Resistance. |
| Q92705363 | Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells |
| Q64227320 | Persistent Organic Pollutant-Mediated Insulin Resistance |
| Q91715082 | Phenformin as an Anticancer Agent: Challenges and Prospects |
| Q90632258 | Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy |
| Q38692106 | Polluted Pathways: Mechanisms of Metabolic Disruption by Endocrine Disrupting Chemicals |
| Q55080861 | Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders. |
| Q47148579 | Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out. |
| Q61810112 | Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice |
| Q90648197 | Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes |
| Q37136815 | Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia |
| Q41960756 | Rational steering of insulin binding specificity by intra-chain chemical crosslinking |
| Q38193038 | Receptor tyrosine kinases: legacy of the first two decades |
| Q92788248 | Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis |
| Q36251999 | Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. |
| Q38705500 | Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier |
| Q103804757 | Regulators of TNFα mediated insulin resistance elucidated by quantitative proteomics |
| Q55407877 | Relation extraction for biological pathway construction using node2vec. |
| Q92482655 | Restoration of insulin receptor improves diabetic phenotype in T2DM mice |
| Q38761287 | Risk factors and mechanisms contributing to TKI-induced vascular events in patients with CML. |
| Q36818384 | Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease |
| Q92443552 | Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment |
| Q90396914 | Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes |
| Q92948135 | Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study |
| Q36290072 | S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. |
| Q93064631 | SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond |
| Q35639903 | ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells |
| Q47860509 | Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus). |
| Q64078243 | Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes |
| Q64100886 | Similarities and Distinctions in the Effects of Metformin and Carbon Monoxide in Immunometabolism |
| Q90533453 | Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans With Type 2 Diabetes |
| Q47371515 | Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding |
| Q34990436 | Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin |
| Q59800358 | Spindle Checkpoint Regulators in Insulin Signaling |
| Q57796809 | Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin |
| Q41139895 | Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs |
| Q55405257 | Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease. |
| Q97885508 | Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue |
| Q64255905 | Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes |
| Q38784181 | Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells |
| Q58555910 | The Akt pathway in oncology therapy and beyond (Review) |
| Q39337962 | The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling |
| Q52657176 | The Destiny of Glucose from a MicroRNA Perspective. |
| Q57114420 | The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps |
| Q64102562 | The Effect of Puguntano Leaf Extract (.) On P38 Mapk Levels and Glut-4 Expression in Type 2 Diabetic Rat Muscle |
| Q37535369 | The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism |
| Q58581282 | The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51 |
| Q91669779 | The Lymphatic System in Obesity, Insulin Resistance, and Cardiovascular Diseases |
| Q27015746 | The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model |
| Q57110498 | The Relationship Between Vitamin B6, Diabetes and Cancer |
| Q64260499 | The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration |
| Q52603907 | The cell biology of systemic insulin function. |
| Q94554762 | The effect of α-terpineol enantiomers on biomarkers of rats fed a high-fat diet |
| Q91810395 | The endocrine function of adipose tissues in health and cardiometabolic disease |
| Q46253403 | The etiology of oxidative stress in insulin resistance |
| Q90589420 | The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells |
| Q92916721 | The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids |
| Q38982413 | The impact of insulin resistance on the kidney and vasculature |
| Q47250401 | The inositol pyrophosphate pathway in health and diseases |
| Q92502835 | The insulin receptor goes nuclear |
| Q57279877 | The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects |
| Q47769540 | Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy. |
| Q87754597 | Transcriptional and Functional Plasticity Induced by Chronic Insulin Exposure in a Mast Cell-Like Basophilic Leukemia Cell Model |
| Q57791805 | Type 2 Diabetes Mellitus and Alzheimer's Disease: Role of Insulin Signalling and Therapeutic Implications |
| Q90059126 | USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation |
| Q90087460 | Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants |
| Q36741939 | Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents |
| Q55128761 | Vaccinium ashei leaves extract alleviates insulin resistance via AMPK independent pathway in C2C12 myotube model. |
| Q54269214 | Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. |
| Q39242378 | Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism. |
| Q64106915 | Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes |
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