The inositol pyrophosphate pathway in health and diseases

scientific article published on 27 December 2017

The inositol pyrophosphate pathway in health and diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/BRV.12392
P8608Fatcat IDrelease_pjd7hdvruzeclgugpzcwivvrbq
P932PMC publication ID6383672
P698PubMed publication ID29282838

P2093author name stringAnutosh Chakraborty
P2860cites workMultiple modes of cytoplasmic dynein regulationQ83531140
An affinity reagent for the recognition of pyrophosphorylated peptidesQ86657216
Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analoguesQ88005751
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolasesQ21284394
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphatesQ22010877
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt familyQ22253958
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approachQ24321897
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cellsQ24530557
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNAQ24568308
A quantitative atlas of mitotic phosphorylationQ24646817
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activationQ24670467
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuronQ26269873
The emerging roles of inositol pyrophosphates in eukaryotic cell physiologyQ26786441
Insulin receptor signaling in normal and insulin-resistant statesQ26823171
The enzymes of human diphosphoinositol polyphosphate metabolismQ26851038
Signaling through C2 domains: more than one lipid targetQ27014032
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowdingQ27675827
IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase familyQ27684442
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatasesQ27932475
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
Back in the water: the return of the inositol phosphatesQ28186774
Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2Q28190925
Evolution of protein kinase signaling from yeast to manQ28205635
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphateQ28205958
Inorganic polyphosphate: essential for growth and survivalQ28240351
The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitusQ28268909
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingQ28276378
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brainQ28304043
The blood-testis barrier and its implications for male contraceptionQ28395237
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolasesQ28510332
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon responseQ28540195
GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinaseQ28571302
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domainsQ28609779
Inositol pyrophosphates: why so many phosphates?Q28652347
IP3 3-kinase opposes NGF driven neurite outgrowthQ28731851
The versatility and universality of calcium signallingQ29547402
Histone methylation in transcriptional controlQ29616553
Mechanisms of specificity in protein phosphorylationQ29617541
Linking DNA methylation and histone modification: patterns and paradigmsQ29617801
Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathwayQ30497487
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivoQ33281051
How does synaptotagmin trigger neurotransmitter release?Q33345212
Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosisQ33516101
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in miceQ37020337
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinaseQ37077554
Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis.Q37126685
Arsenic-based antineoplastic drugs and their mechanisms of actionQ37145891
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresisQ37186675
Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in MiceQ37219919
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesisQ37233462
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.Q37340761
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transportQ37394301
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.Q37398176
Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPsQ37416185
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag releaseQ37482212
Inositol pyrophosphates: structure, enzymology and functionQ37588509
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domainsQ37596231
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donorQ37635615
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domainQ37657049
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!Q37873069
Protein phosphorylation from the perspective of systems biology.Q37961317
Cell signalling by inositol pyrophosphatesQ37989043
Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasisQ38040272
Inositol pyrophosphates: between signalling and metabolismQ38110945
Metabolism and function of myo-inositol and inositol phospholipidsQ38164564
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetesQ38194549
Molecular control of PtdIns(3,4,5)P3 signaling in neutrophilsQ38313393
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.Q38430822
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gainQ38433610
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathwayQ38435784
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysisQ38437282
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinaseQ38522112
Regulation of brown fat by AMP-activated protein kinaseQ38566113
Towards pharmacological intervention in inositol pyrophosphate signallingQ38728101
Chemical tools for interrogating inositol pyrophosphate structure and function.Q38837404
AKT in cancer: new molecular insights and advances in drug developmentQ38846044
Unambiguous Identification of Serine and Threonine Pyrophosphorylation Using Neutral-Loss-Triggered Electron-Transfer/Higher-Energy Collision Dissociation.Q38951747
Inositol phospholipids and cell surface receptor functionQ56091374
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)Q70578917
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cellsQ72952296
The diversity and possible functions of the inositol polyphosphate 5-phosphatasesQ77631387
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigationQ79256314
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificityQ79271161
Extraction and analysis of soluble inositol polyphosphates from yeastQ80093282
Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activityQ36270671
Inositol pyrophosphates: metabolism and signalingQ36375032
Low-grade serous carcinomas of the ovary contain very few point mutationsQ36415602
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
IP6K2 is a client for HSP90 and a target for cancer therapeutics developmentQ36446267
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repairQ36579532
Pleckstrin homology (PH) domains and phosphoinositidesQ36711258
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulenceQ36754718
Regulation of UV-induced DNA damage response by ubiquitylationQ36760894
Nudt3 is an mRNA decapping enzyme that modulates cell migrationQ36812733
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphateQ36835730
Inositol pyrophosphates as mammalian cell signalsQ36886772
Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian CellsQ36898165
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2Q33570316
The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin SignalingQ33631545
Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowthQ33652647
Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signalingQ33746634
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanismQ33888504
Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neuronsQ33964708
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.Q34137530
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to ClinicQ34275641
Small molecule inhibitors of phospholipase C from a novel high-throughput screen.Q34321407
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2Q34397020
The Nudix hydrolase superfamilyQ34479614
Identification of a functional nuclear translocation sequence in hPPIP5K2.Q34481151
Inositol phospholipids and cell surface receptor functionQ34486299
Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapyQ34519192
Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell deathQ34526364
How versatile are inositol phosphate kinases?Q34542639
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.Q34573044
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
New concepts in chronic obstructive pulmonary diseaseQ34930970
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancerQ35034550
Understanding the relationship between DNA methylation and histone lysine methylationQ35046027
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasisQ35056776
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1Q35090038
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urineQ35318869
Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and PathogenicityQ35676308
Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivityQ35695541
Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in celluloQ35913992
Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.Q36176216
The significance of the 1-kinase/1-phosphatase activities of the PPIP5K familyQ38989731
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.Q39329205
An Investigation of PhytinQ39480954
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.Q39885162
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.Q40474530
Genome-wide DNA methylation in saliva and body size of adolescent girls.Q40495062
Protocols for regulation and study of diphosphoinositol polyphosphates.Q40519725
Integrated genomic and proteomic analyses of gene expression in Mammalian cellsQ40538549
Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathwayQ40542484
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
Dependence of energy metabolism on the density of cells in culture.Q41024343
Establishing the stability and reversibility of protein pyrophosphorylation with synthetic peptidesQ41499357
Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L.Q41512865
The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cellsQ41594669
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesisQ41679412
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphateQ41687573
The inositol phosphates in WRK1 rat mammary tumour cellsQ41810643
Inositol hexakisphosphate kinases induce cell death in Huntington diseaseQ41820993
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signalingQ41830941
Insulin signaling: inositol phosphates get into the Akt.Q41841387
Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.Q41846418
Modulation of Epidermal Growth Factor Stimulated ERK Phosphorylation and Cell Motility by Inositol Trisphosphate Kinase.Q41883939
Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo-inositol tetrakisphosphate from Dictyostelium resolved by NMR analysisQ41982271
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.Q42318137
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2+-sensitivity, purification and antibody productionQ42794241
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.Q43074238
Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiaeQ43143870
The SIN1-PH Domain Connects mTORC2 to PI3K.Q43183422
Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathwaysQ44273064
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Accumulation of [3H]-inositol into inositol polyphosphates during development of DictyosteliumQ44610185
KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype.Q44876576
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Inositol pyrophosphates modulate hydrogen peroxide signalling.Q45926680
Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiaeQ46468800
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroupsQ46771498
Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levelsQ46774343
Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activityQ47637691
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activityQ47944803
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatidsQ48028376
Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction.Q50456025
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.Q51055246
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.Q51282160
Influence of inositol pyrophosphates on cellular energy dynamics.Q51847806
Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation.Q52911856
NUDT3 rs206936 is associated with body mass index in obese Japanese women.Q53108028
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.Q53617705
A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins.Q53659145
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.Q54349708
PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.Q55031073
P433issue2
P304page(s)1203-1227
P577publication date2017-12-27
P1433published inBiological ReviewsQ2500948
P1476titleThe inositol pyrophosphate pathway in health and diseases
P478volume93