Inositol pyrophosphates: between signalling and metabolism

scientific article published on June 2013

Inositol pyrophosphates: between signalling and metabolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20130118
P8608Fatcat IDrelease_nquhftdtnjg63i365ue3aotiuy
P698PubMed publication ID23725456

P2093author name stringAdolfo Saiardi
Miranda S C Wilson
Thomas M Livermore
P2860cites workPlc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiaeQ46468800
Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiaeQ46535287
The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroupsQ46771498
Influence of inositol pyrophosphates on cellular energy dynamics.Q51847806
The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level.Q53586659
Chemotaxis in the Absence of PIP3 GradientsQ57983532
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type proteinQ22010421
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinasesQ22010845
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt familyQ22253958
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
Identification and characterization of a novel inositol hexakisphosphate kinaseQ24291558
A conserved family of enzymes that phosphorylate inositol hexakisphosphateQ24301881
Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinaseQ24311755
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stressQ24337620
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cellsQ24530557
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolaseQ24533397
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksQ24612235
mTOR: from growth signal integration to cancer, diabetes and ageingQ24633662
Common mechanisms of PIKK regulationQ24653672
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsQ24672792
How inositol pyrophosphates control cellular phosphate homeostasis?Q27016220
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinaseQ27674034
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowdingQ27675827
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesisQ27929981
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatasesQ27932475
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA exportQ27938472
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinasesQ27939197
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinasesQ28116072
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinaseQ28138219
Inorganic polyphosphate: a molecule of many functionsQ28139415
Back in the water: the return of the inositol phosphatesQ28186774
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphateQ28205958
Inorganic polyphosphate: essential for growth and survivalQ28240351
Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in DictyosteliumQ28331112
The versatility and universality of calcium signallingQ29547402
Membrane recognition by phospholipid-binding domainsQ29614848
Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathwayQ30497487
Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeastQ33395820
Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitationsQ33571626
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinasesQ33836143
Assessing the omnipotence of inositol hexakisphosphateQ33940944
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.Q34137530
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environmentQ34317637
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell deathQ34366232
Phosphorylation of proteins by inositol pyrophosphatesQ34377316
Inositol pyrophosphates regulate endocytic traffickingQ34392736
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2Q34397020
The Nudix hydrolase superfamilyQ34479614
Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.Q34508613
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational eventQ34688142
Common genetic variants associate with serum phosphorus concentrationQ35153194
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinomaQ35208535
Initiating cellular stress responsesQ35830545
Ageing and metabolism: drug discovery opportunitiesQ36174012
Inositol pyrophosphates: metabolism and signalingQ36375032
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.Q36446083
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesisQ36497226
Regulation of nuclear processes by inositol polyphosphatesQ36510091
Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiaeQ36543750
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repairQ36579532
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerasesQ36623674
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes.Q36850372
Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinaseQ37077554
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresisQ37186675
Diphosphoinositol polyphosphates: metabolic messengers?Q37268113
Are inositol pyrophosphates signalling molecules?Q37424939
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag releaseQ37482212
Growth control and ribosome biogenesis.Q37606782
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donorQ37635615
Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domainQ37657049
Mitochondrial fatty acid synthesis and respirationQ37708533
Mitochondrial function, mitochondrial DNA and ageing: a reappraisal.Q37770083
Is telomere length a biomarker of aging? A reviewQ37804610
The signaling role of inositol hexakisphosphate kinases (IP6Ks)Q37805097
Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasisQ38040272
Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcsQ38292519
SnapShot: Inositol phosphatesQ38429481
Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PKQ39647083
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.Q39885162
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cellsQ40046011
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.Q40251135
Signal transduction during environmental stress: InsP8 operates within highly restricted contextsQ40413479
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleQ40583917
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeastQ40750059
Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respirationQ41491807
The inositol phosphates in WRK1 rat mammary tumour cellsQ41810643
Inositol hexakisphosphate kinases induce cell death in Huntington diseaseQ41820993
Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo-inositol tetrakisphosphate from Dictyostelium resolved by NMR analysisQ41982271
The interaction of coatomer with inositol polyphosphates is conserved in Saccharomyces cerevisiaeQ41989824
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gainQ42053859
KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formationQ42325483
Inositol diphosphate signaling regulates telomere lengthQ42641267
Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytesQ42745423
Inositol hexakisphosphate kinases promote autophagy.Q42872768
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphatesQ42971039
Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.Q43074238
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactionsQ44587829
Accumulation of [3H]-inositol into inositol polyphosphates during development of DictyosteliumQ44610185
Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stressQ45021750
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groupsQ45345663
Inositol pyrophosphates modulate hydrogen peroxide signalling.Q45926680
Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiaeQ46128888
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)369-379
P577publication date2013-06-01
P1433published inBiochemical JournalQ864221
P1476titleInositol pyrophosphates: between signalling and metabolism
P478volume452

Reverse relations

cites work (P2860)
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